Bone Regeneration and Remodeling within a Unidirectional Porous Hydroxyapatite Bone Substitute at a Cortical Bone Defect Site: Histological Analysis at One and Two Years after Implantation
Unidirectional porous hydroxyapatite (UDPHAp) is an artificial bone substitute with a unique microstructure consisting of 100–300-µm oval pores that present the material unidirectionally. UDPHAp has a compression strength of 14 MPa and a porosity of 75%, which promotes cell migration and capillary f...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-07-01
|
| Series: | Materials |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1996-1944/8/8/4884 |
| _version_ | 1811254914857304064 |
|---|---|
| author | Masashi Iwasashi Toru Funayama Arata Watanabe Hiroshi Noguchi Toshinori Tsukanishi Yasushi Suetsugu Takeshi Makihara Naoyuki Ochiai Masashi Yamazaki Masataka Sakane |
| author_facet | Masashi Iwasashi Toru Funayama Arata Watanabe Hiroshi Noguchi Toshinori Tsukanishi Yasushi Suetsugu Takeshi Makihara Naoyuki Ochiai Masashi Yamazaki Masataka Sakane |
| author_sort | Masashi Iwasashi |
| collection | DOAJ |
| description | Unidirectional porous hydroxyapatite (UDPHAp) is an artificial bone substitute with a unique microstructure consisting of 100–300-µm oval pores that present the material unidirectionally. UDPHAp has a compression strength of 14 MPa and a porosity of 75%, which promotes cell migration and capillary formation within the material. Despite these advantageous properties, bone remodeling and bone formation with UDPHAp remain unclear. To examine long-term remodeling and differences in bone formation based on the defect site, trapezoidal prism-shaped UDPHAp blocks were implanted into rectangular-shaped cortical bone defects in the proximal tibia of Japanese white rabbits. Histological analysis performed at 52 and 104 weeks after implantation revealed that bone and capillaries had formed within the implanted UDPHAp material. Bone formed within the UDPHAp implanted in the cortical defect of rabbit tibia and remodel up to two years. The percentage of new bone area within UDPHAp was larger in cortical lesions than that in medullary lesions. These findings suggest that UDPHAp is a promising material for the repair of non-critical-sized cortical bone defects. |
| first_indexed | 2024-04-12T17:15:41Z |
| format | Article |
| id | doaj.art-369acb248dd44c078b31d84e99015ffc |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-04-12T17:15:41Z |
| publishDate | 2015-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-369acb248dd44c078b31d84e99015ffc2022-12-22T03:23:39ZengMDPI AGMaterials1996-19442015-07-01884884489410.3390/ma8084884ma8084884Bone Regeneration and Remodeling within a Unidirectional Porous Hydroxyapatite Bone Substitute at a Cortical Bone Defect Site: Histological Analysis at One and Two Years after ImplantationMasashi Iwasashi0Toru Funayama1Arata Watanabe2Hiroshi Noguchi3Toshinori Tsukanishi4Yasushi Suetsugu5Takeshi Makihara6Naoyuki Ochiai7Masashi Yamazaki8Masataka Sakane9Department of Orthopaedic Surgery, Tsukuba Medical Center Hospital, 1-3-1 Amakubo, Tsukuba, Ibaraki 305-8550, JapanDepartment of Orthopaedic Surgery, Kenpoku Medical Center, Takahagi Kyodo Hospital, 1006-9 Agehocho, Kamitetsuna, Takahagi, Ibaraki 318-0004, JapanDepartment of Orthopaedic Surgery, Ichihara Hospital, 3681 Ohzone, Tsukuba, Ibaraki 300-3295, JapanTsukuba Central Hospital, 1589-3 Kashiwada-Cho, Ushiku, Ibaraki 300-1211, JapanDepartment of Orthopaedic Surgery, Kenpoku Medical Center, Takahagi Kyodo Hospital, 1006-9 Agehocho, Kamitetsuna, Takahagi, Ibaraki 318-0004, JapanBiomaterials Unit, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, JapanDepartment of Orthopaedic Surgery, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Orthopaedic Surgery, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Orthopaedic Surgery, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Orthopaedic Surgery, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanUnidirectional porous hydroxyapatite (UDPHAp) is an artificial bone substitute with a unique microstructure consisting of 100–300-µm oval pores that present the material unidirectionally. UDPHAp has a compression strength of 14 MPa and a porosity of 75%, which promotes cell migration and capillary formation within the material. Despite these advantageous properties, bone remodeling and bone formation with UDPHAp remain unclear. To examine long-term remodeling and differences in bone formation based on the defect site, trapezoidal prism-shaped UDPHAp blocks were implanted into rectangular-shaped cortical bone defects in the proximal tibia of Japanese white rabbits. Histological analysis performed at 52 and 104 weeks after implantation revealed that bone and capillaries had formed within the implanted UDPHAp material. Bone formed within the UDPHAp implanted in the cortical defect of rabbit tibia and remodel up to two years. The percentage of new bone area within UDPHAp was larger in cortical lesions than that in medullary lesions. These findings suggest that UDPHAp is a promising material for the repair of non-critical-sized cortical bone defects.http://www.mdpi.com/1996-1944/8/8/4884unidirectional porous hydroxyapatite (UDPHAp)osteogenesisbone remodelingimplantationcortical defect |
| spellingShingle | Masashi Iwasashi Toru Funayama Arata Watanabe Hiroshi Noguchi Toshinori Tsukanishi Yasushi Suetsugu Takeshi Makihara Naoyuki Ochiai Masashi Yamazaki Masataka Sakane Bone Regeneration and Remodeling within a Unidirectional Porous Hydroxyapatite Bone Substitute at a Cortical Bone Defect Site: Histological Analysis at One and Two Years after Implantation Materials unidirectional porous hydroxyapatite (UDPHAp) osteogenesis bone remodeling implantation cortical defect |
| title | Bone Regeneration and Remodeling within a Unidirectional Porous Hydroxyapatite Bone Substitute at a Cortical Bone Defect Site: Histological Analysis at One and Two Years after Implantation |
| title_full | Bone Regeneration and Remodeling within a Unidirectional Porous Hydroxyapatite Bone Substitute at a Cortical Bone Defect Site: Histological Analysis at One and Two Years after Implantation |
| title_fullStr | Bone Regeneration and Remodeling within a Unidirectional Porous Hydroxyapatite Bone Substitute at a Cortical Bone Defect Site: Histological Analysis at One and Two Years after Implantation |
| title_full_unstemmed | Bone Regeneration and Remodeling within a Unidirectional Porous Hydroxyapatite Bone Substitute at a Cortical Bone Defect Site: Histological Analysis at One and Two Years after Implantation |
| title_short | Bone Regeneration and Remodeling within a Unidirectional Porous Hydroxyapatite Bone Substitute at a Cortical Bone Defect Site: Histological Analysis at One and Two Years after Implantation |
| title_sort | bone regeneration and remodeling within a unidirectional porous hydroxyapatite bone substitute at a cortical bone defect site histological analysis at one and two years after implantation |
| topic | unidirectional porous hydroxyapatite (UDPHAp) osteogenesis bone remodeling implantation cortical defect |
| url | http://www.mdpi.com/1996-1944/8/8/4884 |
| work_keys_str_mv | AT masashiiwasashi boneregenerationandremodelingwithinaunidirectionalporoushydroxyapatitebonesubstituteatacorticalbonedefectsitehistologicalanalysisatoneandtwoyearsafterimplantation AT torufunayama boneregenerationandremodelingwithinaunidirectionalporoushydroxyapatitebonesubstituteatacorticalbonedefectsitehistologicalanalysisatoneandtwoyearsafterimplantation AT aratawatanabe boneregenerationandremodelingwithinaunidirectionalporoushydroxyapatitebonesubstituteatacorticalbonedefectsitehistologicalanalysisatoneandtwoyearsafterimplantation AT hiroshinoguchi boneregenerationandremodelingwithinaunidirectionalporoushydroxyapatitebonesubstituteatacorticalbonedefectsitehistologicalanalysisatoneandtwoyearsafterimplantation AT toshinoritsukanishi boneregenerationandremodelingwithinaunidirectionalporoushydroxyapatitebonesubstituteatacorticalbonedefectsitehistologicalanalysisatoneandtwoyearsafterimplantation AT yasushisuetsugu boneregenerationandremodelingwithinaunidirectionalporoushydroxyapatitebonesubstituteatacorticalbonedefectsitehistologicalanalysisatoneandtwoyearsafterimplantation AT takeshimakihara boneregenerationandremodelingwithinaunidirectionalporoushydroxyapatitebonesubstituteatacorticalbonedefectsitehistologicalanalysisatoneandtwoyearsafterimplantation AT naoyukiochiai boneregenerationandremodelingwithinaunidirectionalporoushydroxyapatitebonesubstituteatacorticalbonedefectsitehistologicalanalysisatoneandtwoyearsafterimplantation AT masashiyamazaki boneregenerationandremodelingwithinaunidirectionalporoushydroxyapatitebonesubstituteatacorticalbonedefectsitehistologicalanalysisatoneandtwoyearsafterimplantation AT masatakasakane boneregenerationandremodelingwithinaunidirectionalporoushydroxyapatitebonesubstituteatacorticalbonedefectsitehistologicalanalysisatoneandtwoyearsafterimplantation |