Novel Insights Into MALAT1 Function as a MicroRNA Sponge in NSCLC
The long non-coding RNA metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) was initially found to be overexpressed in early non-small cell lung cancer (NSCLC). Accumulating studies have shown that MALAT1 is overexpressed in the tissue or serum of NSCLC and plays a key role in its occurr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.758653/full |
| _version_ | 1819011572829257728 |
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| author | Qinfeng Zhou Lianfang Liu Jing Zhou Yuanyuan Chen Dacheng Xie Yinan Yao Dawei Cui |
| author_facet | Qinfeng Zhou Lianfang Liu Jing Zhou Yuanyuan Chen Dacheng Xie Yinan Yao Dawei Cui |
| author_sort | Qinfeng Zhou |
| collection | DOAJ |
| description | The long non-coding RNA metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) was initially found to be overexpressed in early non-small cell lung cancer (NSCLC). Accumulating studies have shown that MALAT1 is overexpressed in the tissue or serum of NSCLC and plays a key role in its occurrence and development. In addition, the expression level of MALAT1 is significantly related to the tumor size, stage, metastasis, and distant invasion of NSCLC. Therefore, MALAT1 could be used as a biomarker for the early diagnosis, severity assessment, or prognosis evaluation of NSCLC patients. This review describes the basic properties and biological functions of MALAT1, focuses on the specific molecular mechanism of MALAT1 as a microRNA sponge in the occurrence and development of NSCLC in recent years, and emphasizes the application and potential prospect of MALAT1 in molecular biological markers and targeted therapy of NSCLC. |
| first_indexed | 2024-12-21T01:30:18Z |
| format | Article |
| id | doaj.art-369cd1fdfb164bf8abb5859dc1704f35 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T01:30:18Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-369cd1fdfb164bf8abb5859dc1704f352022-12-21T19:20:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-10-011110.3389/fonc.2021.758653758653Novel Insights Into MALAT1 Function as a MicroRNA Sponge in NSCLCQinfeng Zhou0Lianfang Liu1Jing Zhou2Yuanyuan Chen3Dacheng Xie4Yinan Yao5Dawei Cui6Department of Laboratory Medicine, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, ChinaDepartment of Oncology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, ChinaDepartment of Laboratory Medicine, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, ChinaDepartment of Laboratory Medicine, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, ChinaDepartment of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaThe long non-coding RNA metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) was initially found to be overexpressed in early non-small cell lung cancer (NSCLC). Accumulating studies have shown that MALAT1 is overexpressed in the tissue or serum of NSCLC and plays a key role in its occurrence and development. In addition, the expression level of MALAT1 is significantly related to the tumor size, stage, metastasis, and distant invasion of NSCLC. Therefore, MALAT1 could be used as a biomarker for the early diagnosis, severity assessment, or prognosis evaluation of NSCLC patients. This review describes the basic properties and biological functions of MALAT1, focuses on the specific molecular mechanism of MALAT1 as a microRNA sponge in the occurrence and development of NSCLC in recent years, and emphasizes the application and potential prospect of MALAT1 in molecular biological markers and targeted therapy of NSCLC.https://www.frontiersin.org/articles/10.3389/fonc.2021.758653/fulllong non-coding RNAmetastasis-associated lung adenocarcinoma transcript-1non-small cell lung cancermetastasisinvasionmicroRNA |
| spellingShingle | Qinfeng Zhou Lianfang Liu Jing Zhou Yuanyuan Chen Dacheng Xie Yinan Yao Dawei Cui Novel Insights Into MALAT1 Function as a MicroRNA Sponge in NSCLC Frontiers in Oncology long non-coding RNA metastasis-associated lung adenocarcinoma transcript-1 non-small cell lung cancer metastasis invasion microRNA |
| title | Novel Insights Into MALAT1 Function as a MicroRNA Sponge in NSCLC |
| title_full | Novel Insights Into MALAT1 Function as a MicroRNA Sponge in NSCLC |
| title_fullStr | Novel Insights Into MALAT1 Function as a MicroRNA Sponge in NSCLC |
| title_full_unstemmed | Novel Insights Into MALAT1 Function as a MicroRNA Sponge in NSCLC |
| title_short | Novel Insights Into MALAT1 Function as a MicroRNA Sponge in NSCLC |
| title_sort | novel insights into malat1 function as a microrna sponge in nsclc |
| topic | long non-coding RNA metastasis-associated lung adenocarcinoma transcript-1 non-small cell lung cancer metastasis invasion microRNA |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.758653/full |
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