Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin Resistance
The objective of this study was to evaluate serum, hair, and urinary trace element and mineral content in normal-weight and obese women in relation to metabolic risk factors. A total of 80 women aged 30–70 y.o. were enrolled in the obese group (n = 40) and normal-weight group (n = 40). Serum, hair,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/5/689 |
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| author | Alexey A. Tinkov Paweł Bogdański Damian Skrypnik Katarzyna Skrypnik Anatoly V. Skalny Jan Aaseth Margarita G. Skalnaya Joanna Suliburska |
| author_facet | Alexey A. Tinkov Paweł Bogdański Damian Skrypnik Katarzyna Skrypnik Anatoly V. Skalny Jan Aaseth Margarita G. Skalnaya Joanna Suliburska |
| author_sort | Alexey A. Tinkov |
| collection | DOAJ |
| description | The objective of this study was to evaluate serum, hair, and urinary trace element and mineral content in normal-weight and obese women in relation to metabolic risk factors. A total of 80 women aged 30–70 y.o. were enrolled in the obese group (n = 40) and normal-weight group (n = 40). Serum, hair, and urinary trace element and mineral levels were assessed using inductively coupled plasma spectrometry. Body fat percentage was evaluated using bioimpedance. Obese subjects were characterized by significantly higher body fat percentage, blood pressure, serum triglyceride concentration, and insulin resistance. Serum Ca, Fe, Mg, Se, V, Zn levels, hair Fe, Mg, V content, and urinary Se and V concentrations were found to be lower in obese subjects as compared to lean controls. In turn, serum Cu and urinary Fe levels in obese women were characterized by a significant increase. In multiple regression models serum Cu, Se, and Zn levels were significantly associated with BMI even after adjustment for blood biochemistry, body composition, and blood pressure. Serum trace element and mineral levels also significantly contributed to group discrimination. These findings allow to propose that obesity-associated disturbances in trace element and mineral status may at least partially contribute to metabolic risk in obese subjects. |
| first_indexed | 2024-03-10T11:43:11Z |
| format | Article |
| id | doaj.art-369df78c2dd54715863ef931cdcbfea0 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T11:43:11Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-369df78c2dd54715863ef931cdcbfea02023-11-21T18:19:35ZengMDPI AGBiomolecules2218-273X2021-05-0111568910.3390/biom11050689Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin ResistanceAlexey A. Tinkov0Paweł Bogdański1Damian Skrypnik2Katarzyna Skrypnik3Anatoly V. Skalny4Jan Aaseth5Margarita G. Skalnaya6Joanna Suliburska7Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, Sovetskaya St., 14, 150000 Yaroslavl, RussiaDepartment of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznań University of Medical Sciences, Szamarzewskiego St. 84, 60-569 Poznań, PolandDepartment of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznań University of Medical Sciences, Szamarzewskiego St. 84, 60-569 Poznań, PolandDepartment of Human Nutrition and Dietetics, Poznan University of Life Science, ul. Wojska Polskiego 31, 60-624 Poznan, PolandLaboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, Sovetskaya St., 14, 150000 Yaroslavl, RussiaDepartment of Research, Innlandet Hospital Trust, 2380 Brumunddal, NorwayLaboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, Sovetskaya St., 14, 150000 Yaroslavl, RussiaDepartment of Human Nutrition and Dietetics, Poznan University of Life Science, ul. Wojska Polskiego 31, 60-624 Poznan, PolandThe objective of this study was to evaluate serum, hair, and urinary trace element and mineral content in normal-weight and obese women in relation to metabolic risk factors. A total of 80 women aged 30–70 y.o. were enrolled in the obese group (n = 40) and normal-weight group (n = 40). Serum, hair, and urinary trace element and mineral levels were assessed using inductively coupled plasma spectrometry. Body fat percentage was evaluated using bioimpedance. Obese subjects were characterized by significantly higher body fat percentage, blood pressure, serum triglyceride concentration, and insulin resistance. Serum Ca, Fe, Mg, Se, V, Zn levels, hair Fe, Mg, V content, and urinary Se and V concentrations were found to be lower in obese subjects as compared to lean controls. In turn, serum Cu and urinary Fe levels in obese women were characterized by a significant increase. In multiple regression models serum Cu, Se, and Zn levels were significantly associated with BMI even after adjustment for blood biochemistry, body composition, and blood pressure. Serum trace element and mineral levels also significantly contributed to group discrimination. These findings allow to propose that obesity-associated disturbances in trace element and mineral status may at least partially contribute to metabolic risk in obese subjects.https://www.mdpi.com/2218-273X/11/5/689obesitymetabolic syndromeinsulin resistancecopperselenium |
| spellingShingle | Alexey A. Tinkov Paweł Bogdański Damian Skrypnik Katarzyna Skrypnik Anatoly V. Skalny Jan Aaseth Margarita G. Skalnaya Joanna Suliburska Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin Resistance Biomolecules obesity metabolic syndrome insulin resistance copper selenium |
| title | Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin Resistance |
| title_full | Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin Resistance |
| title_fullStr | Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin Resistance |
| title_full_unstemmed | Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin Resistance |
| title_short | Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin Resistance |
| title_sort | trace element and mineral levels in serum hair and urine of obese women in relation to body composition blood pressure lipid profile and insulin resistance |
| topic | obesity metabolic syndrome insulin resistance copper selenium |
| url | https://www.mdpi.com/2218-273X/11/5/689 |
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