Important problems in the diagnosis and treatment of primary sclerosing cholangitis (based on the Russian consensus on diagnosis and treatment autoimmune hepatitis. Moscow, 2018)
The article is published based on the results of the Russian Consensus on the diagnosis and treatment of primary sclerosing cholangitis (PSC), discussed at the 44th annual Scientific Session of the CNIIG "Personalized Medicine in the Era of Standards" (March 1, 2018). The aim of the review...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2019-02-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32896/pdf |
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| author | E V Vinnitskaya S R Abdulkhakov D T Abdurakhmanov R B Alikhanov I G Bakulin E A Belousova A O Bueverov E Z Burnevitch M G Efanov E Yu Eremina T M Ignatova L Yu Ilchenko G G Karmazanovsky O V Knyazev Yu V Kulezneva T N Lopatkina T P Nekrasova I G Nikitin V V Pavlenko A I Parfenov S D Podymova K L Raichelson A R Reisis R G Sayfutdinov E V Skazyvaeva V E Syutkin S G Khomeriki T Yu Haimenova Yu G Sandler |
| author_facet | E V Vinnitskaya S R Abdulkhakov D T Abdurakhmanov R B Alikhanov I G Bakulin E A Belousova A O Bueverov E Z Burnevitch M G Efanov E Yu Eremina T M Ignatova L Yu Ilchenko G G Karmazanovsky O V Knyazev Yu V Kulezneva T N Lopatkina T P Nekrasova I G Nikitin V V Pavlenko A I Parfenov S D Podymova K L Raichelson A R Reisis R G Sayfutdinov E V Skazyvaeva V E Syutkin S G Khomeriki T Yu Haimenova Yu G Sandler |
| author_sort | E V Vinnitskaya |
| collection | DOAJ |
| description | The article is published based on the results of the Russian Consensus on the diagnosis and treatment of primary sclerosing cholangitis (PSC), discussed at the 44th annual Scientific Session of the CNIIG "Personalized Medicine in the Era of Standards" (March 1, 2018). The aim of the review is to highlight the current issues of classification of diagnosis and treatment of patients with PSC, which causes the greatest interest of specialists. The urgency of the problem is determined by the multivariate nature of the clinical manifestations, by often asymptomatic flow, severe prognosis, complexity of diagnosis and insufficient study of PSC, the natural course of which in some cases can be considered as a function with many variables in terms of the nature and speed of progression with numerous possible clinical outcomes. In addition to progression to portal hypertension, cirrhosis and its complications, PSC can be accompanied by clinical manifestations of obstructive jaundice, bacterial cholangitis, cholangiocarcinoma and colorectal cancer. Magnetic resonance cholangiography is the main method of radial diagnostics of PSC, which allows to obtain an image of bile ducts in an un-invasive way. The use of liver biopsy is best justified when there is a suspicion of small-diameter PSC, autoimmune cross-syndrome PSC-AIG, IgG4-sclerosing cholangitis. Currently, a drug registered to treat primary sclerosing cholangitis which can significantly change the course and prognosis of the disease does not exist. There is no unified view on the effectiveness and usefulness of ursodeoxycholic acid and its dosage in PSC. Early diagnosis and determination of the phenotype of PSC is of clinical importance. It allows to determine the tactics of treatment, detection and prevention of complications |
| first_indexed | 2024-04-12T04:52:10Z |
| format | Article |
| id | doaj.art-369fbd970a524d809c932e64bb20426a |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-12T04:52:10Z |
| publishDate | 2019-02-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-369fbd970a524d809c932e64bb20426a2022-12-22T03:47:15Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422019-02-0191291510.26442/00403660.2019.02.00007529648Important problems in the diagnosis and treatment of primary sclerosing cholangitis (based on the Russian consensus on diagnosis and treatment autoimmune hepatitis. Moscow, 2018)E V Vinnitskaya0S R Abdulkhakov1D T Abdurakhmanov2R B Alikhanov3I G Bakulin4E A Belousova5A O Bueverov6E Z Burnevitch7M G Efanov8E Yu Eremina9T M Ignatova10L Yu Ilchenko11G G Karmazanovsky12O V Knyazev13Yu V Kulezneva14T N Lopatkina15T P Nekrasova16I G Nikitin17V V Pavlenko18A I Parfenov19S D Podymova20K L Raichelson21A R Reisis22R G Sayfutdinov23E V Skazyvaeva24V E Syutkin25S G Khomeriki26T Yu Haimenova27Yu G Sandler28A.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of MoscowKazan Federal UniversityI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)A.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of MoscowI.I. Mechnikov North-Western State Medical University of the Ministry of Health of the Russian FederationM.F. Vladimirsky Moscow Regional Research Clinical InstituteI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)A.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of MoscowMedical Institut of the N.P. Ogarev Mordovia State UniversityI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)N.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian FederationA.V. Vishnevsky Institute of Surgery of the Ministry of Health of the Russian FederationA.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of MoscowA.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of MoscowI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)N.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian FederationStavropol State Medical University of the Ministry of Health of the Russian FederationA.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of MoscowA.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of MoscowSt Petersburg State UniversityCentral Research Institute of Epidemiology of the Federal Service on CustomersKazan State Medical Academy - the Branch of Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian FederationI.I. Mechnikov North-Western State Medical University of the Ministry of Health of the Russian FederationN.V. Sklifosovsky Research Institute of Emergency Medical Care of the Department of Health of MoscowA.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of MoscowA.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of MoscowA.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of MoscowThe article is published based on the results of the Russian Consensus on the diagnosis and treatment of primary sclerosing cholangitis (PSC), discussed at the 44th annual Scientific Session of the CNIIG "Personalized Medicine in the Era of Standards" (March 1, 2018). The aim of the review is to highlight the current issues of classification of diagnosis and treatment of patients with PSC, which causes the greatest interest of specialists. The urgency of the problem is determined by the multivariate nature of the clinical manifestations, by often asymptomatic flow, severe prognosis, complexity of diagnosis and insufficient study of PSC, the natural course of which in some cases can be considered as a function with many variables in terms of the nature and speed of progression with numerous possible clinical outcomes. In addition to progression to portal hypertension, cirrhosis and its complications, PSC can be accompanied by clinical manifestations of obstructive jaundice, bacterial cholangitis, cholangiocarcinoma and colorectal cancer. Magnetic resonance cholangiography is the main method of radial diagnostics of PSC, which allows to obtain an image of bile ducts in an un-invasive way. The use of liver biopsy is best justified when there is a suspicion of small-diameter PSC, autoimmune cross-syndrome PSC-AIG, IgG4-sclerosing cholangitis. Currently, a drug registered to treat primary sclerosing cholangitis which can significantly change the course and prognosis of the disease does not exist. There is no unified view on the effectiveness and usefulness of ursodeoxycholic acid and its dosage in PSC. Early diagnosis and determination of the phenotype of PSC is of clinical importance. It allows to determine the tactics of treatment, detection and prevention of complicationshttps://ter-arkhiv.ru/0040-3660/article/viewFile/32896/pdfprimary sclerosing cholangitisphenotypesliver biopsymagnetic resonance cholangiographyursodeoxycholic acid |
| spellingShingle | E V Vinnitskaya S R Abdulkhakov D T Abdurakhmanov R B Alikhanov I G Bakulin E A Belousova A O Bueverov E Z Burnevitch M G Efanov E Yu Eremina T M Ignatova L Yu Ilchenko G G Karmazanovsky O V Knyazev Yu V Kulezneva T N Lopatkina T P Nekrasova I G Nikitin V V Pavlenko A I Parfenov S D Podymova K L Raichelson A R Reisis R G Sayfutdinov E V Skazyvaeva V E Syutkin S G Khomeriki T Yu Haimenova Yu G Sandler Important problems in the diagnosis and treatment of primary sclerosing cholangitis (based on the Russian consensus on diagnosis and treatment autoimmune hepatitis. Moscow, 2018) Терапевтический архив primary sclerosing cholangitis phenotypes liver biopsy magnetic resonance cholangiography ursodeoxycholic acid |
| title | Important problems in the diagnosis and treatment of primary sclerosing cholangitis (based on the Russian consensus on diagnosis and treatment autoimmune hepatitis. Moscow, 2018) |
| title_full | Important problems in the diagnosis and treatment of primary sclerosing cholangitis (based on the Russian consensus on diagnosis and treatment autoimmune hepatitis. Moscow, 2018) |
| title_fullStr | Important problems in the diagnosis and treatment of primary sclerosing cholangitis (based on the Russian consensus on diagnosis and treatment autoimmune hepatitis. Moscow, 2018) |
| title_full_unstemmed | Important problems in the diagnosis and treatment of primary sclerosing cholangitis (based on the Russian consensus on diagnosis and treatment autoimmune hepatitis. Moscow, 2018) |
| title_short | Important problems in the diagnosis and treatment of primary sclerosing cholangitis (based on the Russian consensus on diagnosis and treatment autoimmune hepatitis. Moscow, 2018) |
| title_sort | important problems in the diagnosis and treatment of primary sclerosing cholangitis based on the russian consensus on diagnosis and treatment autoimmune hepatitis moscow 2018 |
| topic | primary sclerosing cholangitis phenotypes liver biopsy magnetic resonance cholangiography ursodeoxycholic acid |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/32896/pdf |
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