Intrauterine Transmission of Hepatitis B Cannot Be Ruled Out by A Single Negative Hepatitis B e Antigen (HBeAg) Result among Hepatitis B Surface Antigen (HBsAg) - Positive Pregnant Women
BACKGROUND: The risk factors for intrauterine transmission of hepatitis B virus (HBV) in hepatitis B surface antigen (HBsAg)-positive pregnant women are poorly understood. Numerous factors are considered to be involved, including placental barrier, obstetric environment, high viral load, and positiv...
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| Format: | Article |
| Language: | English |
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Secretariat of The Indonesian Biomedical Journal
2024-02-01
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| Series: | Indonesian Biomedical Journal |
| Online Access: | https://inabj.org/index.php/ibj/article/view/2726 |
| _version_ | 1797292671660720128 |
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| author | Maisuri Tadjuddin Chalid Tina Dewi Judistiani Rizalinda Syahril Rina Masadah Dwi Bahagia Febriani Ridha Wahyuni Turyadi Turyadi Muh Nasrum Massi |
| author_facet | Maisuri Tadjuddin Chalid Tina Dewi Judistiani Rizalinda Syahril Rina Masadah Dwi Bahagia Febriani Ridha Wahyuni Turyadi Turyadi Muh Nasrum Massi |
| author_sort | Maisuri Tadjuddin Chalid |
| collection | DOAJ |
| description | BACKGROUND: The risk factors for intrauterine transmission of hepatitis B virus (HBV) in hepatitis B surface antigen (HBsAg)-positive pregnant women are poorly understood. Numerous factors are considered to be involved, including placental barrier, obstetric environment, high viral load, and positivity of hepatitis B e antigen (HBeAg). This study was conducted to investigate the role of placenta barrier, clinical, and viral factors in intrauterine transmission of HBV.
METHODS: A cross-sectional study was conducted involving 1,353 pregnant women who underwent HBsAg screening. Eighty-four (6.2%) women were detected as HBsAg positive and were examined for HBsAg level, anti-HBs, anti-HBc, HBeAg/hepatitis B e antibody (anti-HBe) status, and HBV DNA presence in cord blood. Quantitative HBV DNA was analyzed using real-time polymerase chain reaction (PCR).
RESULTS: Eighty-four of 1,353 subjects were HBsAg-positive. HBV DNA was positive in 28/84 (33.7%) maternal sera, 19/79 (24.05%) placental specimens, and 9/83 (10.84%) in cord blood. There were significant associations between HBV DNA in maternal serum (p=0.000) and placental tissue (p=0.000) with HBV DNA in the cord blood. No clinical factors were associated with HBV DNA transmission in cord blood. Sixty percent of viral load >5.3 log10 copies/mL were found in the cord blood, of which 43.8% HBeAg positive and 3.1% HBeAg negative.
CONCLUSION: Reduced transmission via compartments established the placenta’s barrier function in mother-to-child transmission. A high maternal viral load and positive HBeAg were risk factors for intrauterine transmission, while negative HBeAg still has the possibility of transmission.
KEYWORDS: mother-to-child transmission, hepatitis B virus, intrauterine |
| first_indexed | 2024-03-07T20:00:55Z |
| format | Article |
| id | doaj.art-36a04c2a6ee64bde99d689fe2911bb23 |
| institution | Directory Open Access Journal |
| issn | 2085-3297 2355-9179 |
| language | English |
| last_indexed | 2024-03-07T20:00:55Z |
| publishDate | 2024-02-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj.art-36a04c2a6ee64bde99d689fe2911bb232024-02-28T08:12:53ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792024-02-0116140710.18585/inabj.v16i1.2726556Intrauterine Transmission of Hepatitis B Cannot Be Ruled Out by A Single Negative Hepatitis B e Antigen (HBeAg) Result among Hepatitis B Surface Antigen (HBsAg) - Positive Pregnant WomenMaisuri Tadjuddin Chalid0Tina Dewi Judistiani1Rizalinda Syahril2Rina Masadah3Dwi Bahagia Febriani4Ridha Wahyuni5Turyadi Turyadi6Muh Nasrum Massi7Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Hasanuddin, Jl, Perintis Kemerdekaan KM10, MakassarDepartment of Public Health, Faculty of Medicine, Universitas Padjadjaran, Jl. Ir. Soekarno KM. 21, Jatinangor, SumedangDepartment of Microbiology, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM10, MakassarDepartment of Pathology Anatomy, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM10, MakassarDepartment of Paediatrics, Faculty of Medicine, Universitas Hasanuddin, Jl, Perintis Kemerdekaan KM10, MakassarDepartment of Microbiology, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM10, MakassarEijkman Institutue of Molecular Biology, Jl Diponegoro No. 69, JakartaDepartment of Microbiology, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM10, MakassarBACKGROUND: The risk factors for intrauterine transmission of hepatitis B virus (HBV) in hepatitis B surface antigen (HBsAg)-positive pregnant women are poorly understood. Numerous factors are considered to be involved, including placental barrier, obstetric environment, high viral load, and positivity of hepatitis B e antigen (HBeAg). This study was conducted to investigate the role of placenta barrier, clinical, and viral factors in intrauterine transmission of HBV. METHODS: A cross-sectional study was conducted involving 1,353 pregnant women who underwent HBsAg screening. Eighty-four (6.2%) women were detected as HBsAg positive and were examined for HBsAg level, anti-HBs, anti-HBc, HBeAg/hepatitis B e antibody (anti-HBe) status, and HBV DNA presence in cord blood. Quantitative HBV DNA was analyzed using real-time polymerase chain reaction (PCR). RESULTS: Eighty-four of 1,353 subjects were HBsAg-positive. HBV DNA was positive in 28/84 (33.7%) maternal sera, 19/79 (24.05%) placental specimens, and 9/83 (10.84%) in cord blood. There were significant associations between HBV DNA in maternal serum (p=0.000) and placental tissue (p=0.000) with HBV DNA in the cord blood. No clinical factors were associated with HBV DNA transmission in cord blood. Sixty percent of viral load >5.3 log10 copies/mL were found in the cord blood, of which 43.8% HBeAg positive and 3.1% HBeAg negative. CONCLUSION: Reduced transmission via compartments established the placenta’s barrier function in mother-to-child transmission. A high maternal viral load and positive HBeAg were risk factors for intrauterine transmission, while negative HBeAg still has the possibility of transmission. KEYWORDS: mother-to-child transmission, hepatitis B virus, intrauterinehttps://inabj.org/index.php/ibj/article/view/2726 |
| spellingShingle | Maisuri Tadjuddin Chalid Tina Dewi Judistiani Rizalinda Syahril Rina Masadah Dwi Bahagia Febriani Ridha Wahyuni Turyadi Turyadi Muh Nasrum Massi Intrauterine Transmission of Hepatitis B Cannot Be Ruled Out by A Single Negative Hepatitis B e Antigen (HBeAg) Result among Hepatitis B Surface Antigen (HBsAg) - Positive Pregnant Women Indonesian Biomedical Journal |
| title | Intrauterine Transmission of Hepatitis B Cannot Be Ruled Out by A Single Negative Hepatitis B e Antigen (HBeAg) Result among Hepatitis B Surface Antigen (HBsAg) - Positive Pregnant Women |
| title_full | Intrauterine Transmission of Hepatitis B Cannot Be Ruled Out by A Single Negative Hepatitis B e Antigen (HBeAg) Result among Hepatitis B Surface Antigen (HBsAg) - Positive Pregnant Women |
| title_fullStr | Intrauterine Transmission of Hepatitis B Cannot Be Ruled Out by A Single Negative Hepatitis B e Antigen (HBeAg) Result among Hepatitis B Surface Antigen (HBsAg) - Positive Pregnant Women |
| title_full_unstemmed | Intrauterine Transmission of Hepatitis B Cannot Be Ruled Out by A Single Negative Hepatitis B e Antigen (HBeAg) Result among Hepatitis B Surface Antigen (HBsAg) - Positive Pregnant Women |
| title_short | Intrauterine Transmission of Hepatitis B Cannot Be Ruled Out by A Single Negative Hepatitis B e Antigen (HBeAg) Result among Hepatitis B Surface Antigen (HBsAg) - Positive Pregnant Women |
| title_sort | intrauterine transmission of hepatitis b cannot be ruled out by a single negative hepatitis b e antigen hbeag result among hepatitis b surface antigen hbsag positive pregnant women |
| url | https://inabj.org/index.php/ibj/article/view/2726 |
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