AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)
Abstract Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, rece...
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| Format: | Article |
| Language: | English |
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Wiley
2020-07-01
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| Series: | Clinical and Translational Allergy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13601-020-00335-w |
| _version_ | 1819136621154402304 |
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| author | D. Ferastraoaru H. J. Bax C. Bergmann M. Capron M. Castells D. Dombrowicz E. Fiebiger H. J. Gould K. Hartmann U. Jappe G. Jordakieva D. H. Josephs F. Levi-Schaffer V. Mahler A. Poli D. Rosenstreich F. Roth-Walter M. Shamji E. H. Steveling-Klein M. C. Turner E. Untersmayr S. N. Karagiannis E. Jensen-Jarolim |
| author_facet | D. Ferastraoaru H. J. Bax C. Bergmann M. Capron M. Castells D. Dombrowicz E. Fiebiger H. J. Gould K. Hartmann U. Jappe G. Jordakieva D. H. Josephs F. Levi-Schaffer V. Mahler A. Poli D. Rosenstreich F. Roth-Walter M. Shamji E. H. Steveling-Klein M. C. Turner E. Untersmayr S. N. Karagiannis E. Jensen-Jarolim |
| author_sort | D. Ferastraoaru |
| collection | DOAJ |
| description | Abstract Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, recent studies reveal a correlation between IgE deficiency and increased malignancy risk. This is the first review discussing IgE levels and links to pathological conditions, with special focus on the potential clinical significance of ultra-low serum IgE levels and risk of malignancy. In this Position Paper we discuss: (a) the utility of measuring total IgE levels in the management of allergies, parasitosis, and immunodeficiencies, (b) factors that may influence serum IgE levels, (c) IgE as a marker of different disorders, and d) the relationship between ultra-low IgE levels and malignancy susceptibility. While elevated serum IgE is generally associated with allergic/atopic conditions, very low or absent IgE may hamper anti-tumour surveillance, indicating the importance of a balanced IgE-mediated immune function. Ultra-low IgE may prove to be an unexpected biomarker for cancer risk. Nevertheless, given the early stage of investigations conducted mostly in patients with diseases that influence IgE levels, in-depth mechanistic studies and stratification of malignancy risk based on associated demographic, immunological and clinical co-factors are warranted. |
| first_indexed | 2024-12-22T10:37:53Z |
| format | Article |
| id | doaj.art-36a0b020323b456eaa5ab6efccfb84e4 |
| institution | Directory Open Access Journal |
| issn | 2045-7022 |
| language | English |
| last_indexed | 2024-12-22T10:37:53Z |
| publishDate | 2020-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj.art-36a0b020323b456eaa5ab6efccfb84e42022-12-21T18:29:06ZengWileyClinical and Translational Allergy2045-70222020-07-0110111610.1186/s13601-020-00335-wAllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)D. Ferastraoaru0H. J. Bax1C. Bergmann2M. Capron3M. Castells4D. Dombrowicz5E. Fiebiger6H. J. Gould7K. Hartmann8U. Jappe9G. Jordakieva10D. H. Josephs11F. Levi-Schaffer12V. Mahler13A. Poli14D. Rosenstreich15F. Roth-Walter16M. Shamji17E. H. Steveling-Klein18M. C. Turner19E. Untersmayr20S. N. Karagiannis21E. Jensen-Jarolim22Department of Internal Medicine/Allergy and Immunology, Albert Einstein College of Medicine, Montefiore Medical CenterSt. John’s Institute of Dermatology, School of Basic & Medical Biosciences, King’s College London, Guy’s HospitalENT Research Institute for Clinical StudiesLIRIC-Unite Mixte de Recherche 995 INSERM, Universite de Lille 2, CHRU de LilleDivision of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolRecepteurs Nucleaires, Maladies Cardiovasculaires et Diabete, Univ. Lille, Inserm, CHU Lille, Institut Pasteur de LilleDivision of Gastroenterology, Hepatology and Nutrition Research, Department of Medicine Research, Children’s University Hospital BostonRandall Centre for Cell and Molecular Biophysics, School of Basic & Medical Biosciences, King’s College LondonDepartment of Dermatology, University of LuebeckInterdisciplinary Allergy Outpatient Clinic, Department of Pneumology, University of LuebeckDepartment of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of ViennaSt. John’s Institute of Dermatology, School of Basic & Medical Biosciences, King’s College London, Guy’s HospitalPharmacology and Experimental Therapeutics Unit, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of JerusalemDivision of Allergology, Paul-Ehrlich-Institut, Federal Institute for Vaccines and BiomedicinesDepartment of Infection and Immunity, Luxembourg Institute of HealthDepartment of Internal Medicine/Allergy and Immunology, Albert Einstein College of Medicine, Montefiore Medical CenterThe Interuniversity Messerli Research Inst, Univ. of Vet. Medicine Vienna, Med. Univ. Vienna, Univ. ViennaImmunomodulation and Tolerance Group, Imperial College London, and Allergy and Clinical Immunology, Imperial College LondonDepartment of Dermatology, Allergy Division, University Hospital BaselBarcelona Institute for Global Health (ISGlobal)Institute of Pathophysiology and Allergy Research, Medical University ViennaSt. John’s Institute of Dermatology, School of Basic & Medical Biosciences, King’s College London, Guy’s HospitalThe Interuniversity Messerli Research Inst, Univ. of Vet. Medicine Vienna, Med. Univ. Vienna, Univ. ViennaAbstract Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, recent studies reveal a correlation between IgE deficiency and increased malignancy risk. This is the first review discussing IgE levels and links to pathological conditions, with special focus on the potential clinical significance of ultra-low serum IgE levels and risk of malignancy. In this Position Paper we discuss: (a) the utility of measuring total IgE levels in the management of allergies, parasitosis, and immunodeficiencies, (b) factors that may influence serum IgE levels, (c) IgE as a marker of different disorders, and d) the relationship between ultra-low IgE levels and malignancy susceptibility. While elevated serum IgE is generally associated with allergic/atopic conditions, very low or absent IgE may hamper anti-tumour surveillance, indicating the importance of a balanced IgE-mediated immune function. Ultra-low IgE may prove to be an unexpected biomarker for cancer risk. Nevertheless, given the early stage of investigations conducted mostly in patients with diseases that influence IgE levels, in-depth mechanistic studies and stratification of malignancy risk based on associated demographic, immunological and clinical co-factors are warranted.http://link.springer.com/article/10.1186/s13601-020-00335-wIgEAllergy diagnosisAtopyCancerMalignancy |
| spellingShingle | D. Ferastraoaru H. J. Bax C. Bergmann M. Capron M. Castells D. Dombrowicz E. Fiebiger H. J. Gould K. Hartmann U. Jappe G. Jordakieva D. H. Josephs F. Levi-Schaffer V. Mahler A. Poli D. Rosenstreich F. Roth-Walter M. Shamji E. H. Steveling-Klein M. C. Turner E. Untersmayr S. N. Karagiannis E. Jensen-Jarolim AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI) Clinical and Translational Allergy IgE Allergy diagnosis Atopy Cancer Malignancy |
| title | AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI) |
| title_full | AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI) |
| title_fullStr | AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI) |
| title_full_unstemmed | AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI) |
| title_short | AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI) |
| title_sort | allergooncology ultra low ige a potential novel biomarker in cancer a position paper of the european academy of allergy and clinical immunology eaaci |
| topic | IgE Allergy diagnosis Atopy Cancer Malignancy |
| url | http://link.springer.com/article/10.1186/s13601-020-00335-w |
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