Shift Work and the Risk of Cardiometabolic Multimorbidity Among Patients With Hypertension: A Prospective Cohort Study of UK Biobank
Background Although the association between shift work and individual cardiometabolic diseases has been well studied, its role in the progression to cardiometabolic multimorbidity (CMM) remains unclear. In this study, we investigate the association between shift work and the incidence of CMM in pati...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-09-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.025936 |
| _version_ | 1798033686211330048 |
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| author | Liu Yang Yi Luo Lingfang He Jinghua Yin Tie Li Shuai Liu Dongjie Li Xunjie Cheng Yongping Bai |
| author_facet | Liu Yang Yi Luo Lingfang He Jinghua Yin Tie Li Shuai Liu Dongjie Li Xunjie Cheng Yongping Bai |
| author_sort | Liu Yang |
| collection | DOAJ |
| description | Background Although the association between shift work and individual cardiometabolic diseases has been well studied, its role in the progression to cardiometabolic multimorbidity (CMM) remains unclear. In this study, we investigate the association between shift work and the incidence of CMM in patients with hypertension. Methods and Results This study is a population‐based and prospective cohort study on 36 939 UK Biobank participants. We used competing risk models to examine the association between shift work and the risk of CMM, which was defined as coexistence of hypertension and diabetes, coronary heart disease, or stroke in our study. We also investigated the association between the frequency and duration of shift work and CMM risks. In addition, we conducted a cross‐classification analysis with the combination of frequency and duration of shift work, chronotype and sleep duration as the exposure metrics. During a median follow‐up of 11.6 years, a total of 5935 participants developed CMM. We found that usually/always night shift workers were associated with a 16% higher risk of CMM compared with day workers (hazard ratio [HR], 1.16 [95% CI, 1.02–1.31]). We also found that a higher frequency of night shifts (>10/month) was associated with increased risk of CMM (HR, 1.19 [95% CI, 1.06–1.34]) that was more pronounced for >10/month in combination with a morning chronotype or <7 hours or >8 hours of sleep duration (HR, 1.26 [95% CI, 1.02–1.56]; HR, 1.43 [95% CI, 1.19–1.72], respectively). Conclusions We find that night shift work is associated with higher CMM risk in patients with hypertension. |
| first_indexed | 2024-04-11T20:34:05Z |
| format | Article |
| id | doaj.art-36a155b487d94225a17cb0b63975f11e |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-11T20:34:05Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-36a155b487d94225a17cb0b63975f11e2022-12-22T04:04:25ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-09-01111710.1161/JAHA.122.025936Shift Work and the Risk of Cardiometabolic Multimorbidity Among Patients With Hypertension: A Prospective Cohort Study of UK BiobankLiu Yang0Yi Luo1Lingfang He2Jinghua Yin3Tie Li4Shuai Liu5Dongjie Li6Xunjie Cheng7Yongping Bai8Xiangya International Medical Center Xiangya Hospital, Central South University Changsha Hunan ChinaDepartment of Cardiovascular Medicine The Third Xiangya Hospital, Central South University Changsha Hunan ChinaDepartment of Geriatric Medicine, Center of Coronary Circulation Xiangya Hospital, Central South University Changsha Hunan ChinaDepartment of Geriatric Medicine, Center of Coronary Circulation Xiangya Hospital, Central South University Changsha Hunan ChinaDepartment of Cardiovascular Medicine Changsha County Second People’s Hospital Changsha Hunan ChinaDepartment of General and Vascular Surgery Xiangya Hospital, Central South University Changsha Hunan ChinaXiangya International Medical Center Xiangya Hospital, Central South University Changsha Hunan ChinaDepartment of Geriatric Medicine, Center of Coronary Circulation Xiangya Hospital, Central South University Changsha Hunan ChinaDepartment of Geriatric Medicine, Center of Coronary Circulation Xiangya Hospital, Central South University Changsha Hunan ChinaBackground Although the association between shift work and individual cardiometabolic diseases has been well studied, its role in the progression to cardiometabolic multimorbidity (CMM) remains unclear. In this study, we investigate the association between shift work and the incidence of CMM in patients with hypertension. Methods and Results This study is a population‐based and prospective cohort study on 36 939 UK Biobank participants. We used competing risk models to examine the association between shift work and the risk of CMM, which was defined as coexistence of hypertension and diabetes, coronary heart disease, or stroke in our study. We also investigated the association between the frequency and duration of shift work and CMM risks. In addition, we conducted a cross‐classification analysis with the combination of frequency and duration of shift work, chronotype and sleep duration as the exposure metrics. During a median follow‐up of 11.6 years, a total of 5935 participants developed CMM. We found that usually/always night shift workers were associated with a 16% higher risk of CMM compared with day workers (hazard ratio [HR], 1.16 [95% CI, 1.02–1.31]). We also found that a higher frequency of night shifts (>10/month) was associated with increased risk of CMM (HR, 1.19 [95% CI, 1.06–1.34]) that was more pronounced for >10/month in combination with a morning chronotype or <7 hours or >8 hours of sleep duration (HR, 1.26 [95% CI, 1.02–1.56]; HR, 1.43 [95% CI, 1.19–1.72], respectively). Conclusions We find that night shift work is associated with higher CMM risk in patients with hypertension.https://www.ahajournals.org/doi/10.1161/JAHA.122.025936biological specimen banksfollow‐up studiesincidencemultimorbidityprospective studiesshift work schedule |
| spellingShingle | Liu Yang Yi Luo Lingfang He Jinghua Yin Tie Li Shuai Liu Dongjie Li Xunjie Cheng Yongping Bai Shift Work and the Risk of Cardiometabolic Multimorbidity Among Patients With Hypertension: A Prospective Cohort Study of UK Biobank Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease biological specimen banks follow‐up studies incidence multimorbidity prospective studies shift work schedule |
| title | Shift Work and the Risk of Cardiometabolic Multimorbidity Among Patients With Hypertension: A Prospective Cohort Study of UK Biobank |
| title_full | Shift Work and the Risk of Cardiometabolic Multimorbidity Among Patients With Hypertension: A Prospective Cohort Study of UK Biobank |
| title_fullStr | Shift Work and the Risk of Cardiometabolic Multimorbidity Among Patients With Hypertension: A Prospective Cohort Study of UK Biobank |
| title_full_unstemmed | Shift Work and the Risk of Cardiometabolic Multimorbidity Among Patients With Hypertension: A Prospective Cohort Study of UK Biobank |
| title_short | Shift Work and the Risk of Cardiometabolic Multimorbidity Among Patients With Hypertension: A Prospective Cohort Study of UK Biobank |
| title_sort | shift work and the risk of cardiometabolic multimorbidity among patients with hypertension a prospective cohort study of uk biobank |
| topic | biological specimen banks follow‐up studies incidence multimorbidity prospective studies shift work schedule |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.025936 |
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