Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes–A Systematic Review
Preterm premature rupture of membranes, leading to preterm birth, is associated with neonatal and maternal morbidity and mortality. The study aimed to review the existing data on the best predictive value of pregnancy latency for known biomarkers in pregnancies after preterm premature rupture of mem...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/9/8027 |
| _version_ | 1797602432382926848 |
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| author | Stepan Feduniw Michal Pruc Michal Ciebiera Natalia Zeber-Lubecka Diana Massalska Magdalena Zgliczynska Agnieszka Pawlowska Lukasz Szarpak |
| author_facet | Stepan Feduniw Michal Pruc Michal Ciebiera Natalia Zeber-Lubecka Diana Massalska Magdalena Zgliczynska Agnieszka Pawlowska Lukasz Szarpak |
| author_sort | Stepan Feduniw |
| collection | DOAJ |
| description | Preterm premature rupture of membranes, leading to preterm birth, is associated with neonatal and maternal morbidity and mortality. The study aimed to review the existing data on the best predictive value of pregnancy latency for known biomarkers in pregnancies after preterm premature rupture of membranes. The following databases were screened for the purposes of this systematic review: Pubmed/MEDLINE, Web of Science, EMBASE, Scopus, and the Cochrane Library. The study was conducted according to the PRISMA guidelines for systematic reviews. Only a few studies assessed biomarkers predicting pregnancy duration after PPROM. IL-6, IL-8, CRP, IL1RA, s-endoglin, βhCG, AFP, PCT, urea, creatinine, oxygen radical absorbance capacity, MDA, lipocalin-2, endotoxin activity, MMP-8, MMP-9 and S100 A8/A9 were found to have a positive predictive value for delivery timing prediction. Proinflammatory biomarkers, such as IL-6 or CRP, proved to be best correlated with delivery timing, independent of the occurrence of intrauterine infection. |
| first_indexed | 2024-03-11T04:16:57Z |
| format | Article |
| id | doaj.art-36a20e2e51d44accb05d0e88eff3c99b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:16:57Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-36a20e2e51d44accb05d0e88eff3c99b2023-11-17T23:03:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01249802710.3390/ijms24098027Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes–A Systematic ReviewStepan Feduniw0Michal Pruc1Michal Ciebiera2Natalia Zeber-Lubecka3Diana Massalska4Magdalena Zgliczynska5Agnieszka Pawlowska6Lukasz Szarpak7Department of Gynecology, University Zürich, Frauenklinikstrasse 10, 8091 Zürich, SwitzerlandResearch Unit, Polish Society of Disaster Medicine, 05-806 Warsaw, PolandSecond Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, Inflancka 6, 00-189 Warsaw, PolandDepartment of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, Roentgena 5, 02-781 Warsaw, PolandSecond Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, Inflancka 6, 00-189 Warsaw, PolandDepartment of Obstetrics, Perinatology and Neonatology, Centre of Postgraduate Medical Education, 01-813 Warsaw, PolandStudent Scientific Circle of Gynecology and Obstetrics “Żelazna”, Warsaw Medical University, Żwirki i Wigury 61, 02-091 Warsaw, PolandHenry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX 77030, USAPreterm premature rupture of membranes, leading to preterm birth, is associated with neonatal and maternal morbidity and mortality. The study aimed to review the existing data on the best predictive value of pregnancy latency for known biomarkers in pregnancies after preterm premature rupture of membranes. The following databases were screened for the purposes of this systematic review: Pubmed/MEDLINE, Web of Science, EMBASE, Scopus, and the Cochrane Library. The study was conducted according to the PRISMA guidelines for systematic reviews. Only a few studies assessed biomarkers predicting pregnancy duration after PPROM. IL-6, IL-8, CRP, IL1RA, s-endoglin, βhCG, AFP, PCT, urea, creatinine, oxygen radical absorbance capacity, MDA, lipocalin-2, endotoxin activity, MMP-8, MMP-9 and S100 A8/A9 were found to have a positive predictive value for delivery timing prediction. Proinflammatory biomarkers, such as IL-6 or CRP, proved to be best correlated with delivery timing, independent of the occurrence of intrauterine infection.https://www.mdpi.com/1422-0067/24/9/8027PPROMpreterm premature rupture of membranespregnancy latencytiming to deliveryPTBpreterm birth |
| spellingShingle | Stepan Feduniw Michal Pruc Michal Ciebiera Natalia Zeber-Lubecka Diana Massalska Magdalena Zgliczynska Agnieszka Pawlowska Lukasz Szarpak Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes–A Systematic Review International Journal of Molecular Sciences PPROM preterm premature rupture of membranes pregnancy latency timing to delivery PTB preterm birth |
| title | Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes–A Systematic Review |
| title_full | Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes–A Systematic Review |
| title_fullStr | Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes–A Systematic Review |
| title_full_unstemmed | Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes–A Systematic Review |
| title_short | Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes–A Systematic Review |
| title_sort | biomarkers for pregnancy latency prediction after preterm premature rupture of membranes a systematic review |
| topic | PPROM preterm premature rupture of membranes pregnancy latency timing to delivery PTB preterm birth |
| url | https://www.mdpi.com/1422-0067/24/9/8027 |
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