Early-Onset Colorectal Cancer: Current Insights
Over the past decade, the incidence of colorectal cancer has increased in individuals under the age of 50 years. Meanwhile, the incidence has gradually decreased in the older population. As described herein, we reviewed the available literature to summarize the current landscape of early-onset color...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/12/3202 |
| _version_ | 1797436050115657728 |
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| author | Fauzia Ullah Ashwathy Balachandran Pillai Najiullah Omar Danai Dima Seema Harichand |
| author_facet | Fauzia Ullah Ashwathy Balachandran Pillai Najiullah Omar Danai Dima Seema Harichand |
| author_sort | Fauzia Ullah |
| collection | DOAJ |
| description | Over the past decade, the incidence of colorectal cancer has increased in individuals under the age of 50 years. Meanwhile, the incidence has gradually decreased in the older population. As described herein, we reviewed the available literature to summarize the current landscape of early-onset colorectal cancer, including risk factors, clinicopathological presentation, genetic makeup of patients, and management. Currently, early-onset colorectal cancer is treated similarly as late-onset colorectal cancer, yet the available literature shows that early-onset colorectal cancer is more aggressive and different, and this remains a significant unmet need. A detailed understanding of early-onset colorectal cancer is needed to identify risk factors for the increased incidence and tailor treatments accordingly. |
| first_indexed | 2024-03-09T10:57:04Z |
| format | Article |
| id | doaj.art-36a24048558d44d0b4a71f6ecc8fb371 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T10:57:04Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-36a24048558d44d0b4a71f6ecc8fb3712023-12-01T01:32:49ZengMDPI AGCancers2072-66942023-06-011512320210.3390/cancers15123202Early-Onset Colorectal Cancer: Current InsightsFauzia Ullah0Ashwathy Balachandran Pillai1Najiullah Omar2Danai Dima3Seema Harichand4Department of Translational Hematology and Oncology Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USADepartment of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Translational Hematology and Oncology Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USADepartment of Translational Hematology and Oncology Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USADepartment of Internal Medicine, Mission Cancer + Blood, University of Iowa, Des Moines, IA 50309, USAOver the past decade, the incidence of colorectal cancer has increased in individuals under the age of 50 years. Meanwhile, the incidence has gradually decreased in the older population. As described herein, we reviewed the available literature to summarize the current landscape of early-onset colorectal cancer, including risk factors, clinicopathological presentation, genetic makeup of patients, and management. Currently, early-onset colorectal cancer is treated similarly as late-onset colorectal cancer, yet the available literature shows that early-onset colorectal cancer is more aggressive and different, and this remains a significant unmet need. A detailed understanding of early-onset colorectal cancer is needed to identify risk factors for the increased incidence and tailor treatments accordingly.https://www.mdpi.com/2072-6694/15/12/3202early-onset colorectal cancergenetic makeupmodifiable risk factorsLynch syndrome |
| spellingShingle | Fauzia Ullah Ashwathy Balachandran Pillai Najiullah Omar Danai Dima Seema Harichand Early-Onset Colorectal Cancer: Current Insights Cancers early-onset colorectal cancer genetic makeup modifiable risk factors Lynch syndrome |
| title | Early-Onset Colorectal Cancer: Current Insights |
| title_full | Early-Onset Colorectal Cancer: Current Insights |
| title_fullStr | Early-Onset Colorectal Cancer: Current Insights |
| title_full_unstemmed | Early-Onset Colorectal Cancer: Current Insights |
| title_short | Early-Onset Colorectal Cancer: Current Insights |
| title_sort | early onset colorectal cancer current insights |
| topic | early-onset colorectal cancer genetic makeup modifiable risk factors Lynch syndrome |
| url | https://www.mdpi.com/2072-6694/15/12/3202 |
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