Circulating miR-1826 in plasma correlates with circulating tumor cells and is a prognostic marker in colorectal cancer
Our previous study showed that miR-1826 was a newly identified oncogenic non-coding RNA in colorectal cancer. But the potential relationship between miR-1826 and tumor metastasis has not been fully elucidated. The purpose of this study was to evaluate the clinical significance of circulating miR-182...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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IOS Press
2017-04-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317705333 |
| _version_ | 1819025439613517824 |
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| author | Zhihua Xu Tianyi Xi Ye Han Xiaobo Guo Fei Liu Min Jiang Daiwei Wan Xiaofeng Xue Songbing He Rui Ren Wei Li Qiaoming Zhi |
| author_facet | Zhihua Xu Tianyi Xi Ye Han Xiaobo Guo Fei Liu Min Jiang Daiwei Wan Xiaofeng Xue Songbing He Rui Ren Wei Li Qiaoming Zhi |
| author_sort | Zhihua Xu |
| collection | DOAJ |
| description | Our previous study showed that miR-1826 was a newly identified oncogenic non-coding RNA in colorectal cancer. But the potential relationship between miR-1826 and tumor metastasis has not been fully elucidated. The purpose of this study was to evaluate the clinical significance of circulating miR-1826 and its possible associations with circulating tumor cells in colorectal cancer. Our results first found that serum miR-1826 was significantly upregulated in colorectal cancer patients, compared with that in healthy volunteers ( p = 0.003). Similar results were also found in colorectal cancer with distant metastasis ( p = 0.001) and advanced colorectal cancer ( p < 0.001) patients, respectively. Clinicopathological analysis implied that circulating miR-1826 was positively associated with pT stage ( p = 0.026), lymphatic metastasis ( p = 0.034), distant metastasis ( p = 0.012), and tumor–node–metastasis stage ( p = 0.020). Besides, our univariate and multivariate analyses demonstrated that high serum miR-1826 expression could act as a prognostic and independent factor for overall survival of colorectal cancer patients ( p < 0.05), which led to a poorer 5-year overall survival rate ( p = 0.025). The area under the curve value of circulating miR-1826 was up to 0.848 ± 0.043, which strongly suggested serum miR-1826 as an effective diagnostic biomarker in colorectal cancer patients ( p < 0.001). Our subsequent experiments demonstrated that patients with high level of circulating tumor cells showed a higher level of miR-1826 expression, compared with the circulating tumor cell–negative patients ( p = 0.011). Similar results also showed that the amount of circulating tumor cells in high miR-1826 group was significantly higher than that in low miR-1826 group ( p = 0.001). Furthermore, the relationship between serum miR-1826 and circulating tumor cells was analyzed using SPSS software and a significant logarithmic relationship was found, which meant that circulating miR-1826 closely correlated with the amount of circulating tumor cells in colorectal cancer patient serum ( r = 0.283, p < 0.01). Our findings strongly suggested that serum miR-1826 could serve as an effective and non-invasive biomarker for diagnosis and prognosis of colorectal cancer. Circulating miR-1826 may be an important target in colorectal cancer therapy. |
| first_indexed | 2024-12-21T05:10:42Z |
| format | Article |
| id | doaj.art-36a24c91574749e28ea85dc55af6a492 |
| institution | Directory Open Access Journal |
| issn | 1423-0380 |
| language | English |
| last_indexed | 2024-12-21T05:10:42Z |
| publishDate | 2017-04-01 |
| publisher | IOS Press |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj.art-36a24c91574749e28ea85dc55af6a4922022-12-21T19:15:03ZengIOS PressTumor Biology1423-03802017-04-013910.1177/1010428317705333Circulating miR-1826 in plasma correlates with circulating tumor cells and is a prognostic marker in colorectal cancerZhihua Xu0Tianyi Xi1Ye Han2Xiaobo Guo3Fei Liu4Min Jiang5Daiwei Wan6Xiaofeng Xue7Songbing He8Rui Ren9Wei Li10Qiaoming Zhi11Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of General Surgery, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, ChinaDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, ChinaOur previous study showed that miR-1826 was a newly identified oncogenic non-coding RNA in colorectal cancer. But the potential relationship between miR-1826 and tumor metastasis has not been fully elucidated. The purpose of this study was to evaluate the clinical significance of circulating miR-1826 and its possible associations with circulating tumor cells in colorectal cancer. Our results first found that serum miR-1826 was significantly upregulated in colorectal cancer patients, compared with that in healthy volunteers ( p = 0.003). Similar results were also found in colorectal cancer with distant metastasis ( p = 0.001) and advanced colorectal cancer ( p < 0.001) patients, respectively. Clinicopathological analysis implied that circulating miR-1826 was positively associated with pT stage ( p = 0.026), lymphatic metastasis ( p = 0.034), distant metastasis ( p = 0.012), and tumor–node–metastasis stage ( p = 0.020). Besides, our univariate and multivariate analyses demonstrated that high serum miR-1826 expression could act as a prognostic and independent factor for overall survival of colorectal cancer patients ( p < 0.05), which led to a poorer 5-year overall survival rate ( p = 0.025). The area under the curve value of circulating miR-1826 was up to 0.848 ± 0.043, which strongly suggested serum miR-1826 as an effective diagnostic biomarker in colorectal cancer patients ( p < 0.001). Our subsequent experiments demonstrated that patients with high level of circulating tumor cells showed a higher level of miR-1826 expression, compared with the circulating tumor cell–negative patients ( p = 0.011). Similar results also showed that the amount of circulating tumor cells in high miR-1826 group was significantly higher than that in low miR-1826 group ( p = 0.001). Furthermore, the relationship between serum miR-1826 and circulating tumor cells was analyzed using SPSS software and a significant logarithmic relationship was found, which meant that circulating miR-1826 closely correlated with the amount of circulating tumor cells in colorectal cancer patient serum ( r = 0.283, p < 0.01). Our findings strongly suggested that serum miR-1826 could serve as an effective and non-invasive biomarker for diagnosis and prognosis of colorectal cancer. Circulating miR-1826 may be an important target in colorectal cancer therapy.https://doi.org/10.1177/1010428317705333 |
| spellingShingle | Zhihua Xu Tianyi Xi Ye Han Xiaobo Guo Fei Liu Min Jiang Daiwei Wan Xiaofeng Xue Songbing He Rui Ren Wei Li Qiaoming Zhi Circulating miR-1826 in plasma correlates with circulating tumor cells and is a prognostic marker in colorectal cancer Tumor Biology |
| title | Circulating miR-1826 in plasma correlates with circulating tumor cells and is a prognostic marker in colorectal cancer |
| title_full | Circulating miR-1826 in plasma correlates with circulating tumor cells and is a prognostic marker in colorectal cancer |
| title_fullStr | Circulating miR-1826 in plasma correlates with circulating tumor cells and is a prognostic marker in colorectal cancer |
| title_full_unstemmed | Circulating miR-1826 in plasma correlates with circulating tumor cells and is a prognostic marker in colorectal cancer |
| title_short | Circulating miR-1826 in plasma correlates with circulating tumor cells and is a prognostic marker in colorectal cancer |
| title_sort | circulating mir 1826 in plasma correlates with circulating tumor cells and is a prognostic marker in colorectal cancer |
| url | https://doi.org/10.1177/1010428317705333 |
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