Evaluation of Dynamic Disulphide/Thiol Homeostasis in Silica Exposed Workers
Background: Oxidative stress is implicated as one of the main molecular mechanism underlying silicosis. Aims: In this study, our aim was to asses the redox status in occupationally silica-exposed workers, by evaluating the dynamic thiol-disulphide homeostasis. Study Design: Case-control study. Me...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2017-04-01
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| Series: | Balkan Medical Journal |
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| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=1798 |
| _version_ | 1828015080267055104 |
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| author | Meşide Gündüzöz Ceylan Bal Murat Büyükşekerci Salim Neşelioğlu Türkan Nadir Öziş Servet İritaş Halil Kara Özcan Erel |
| author_facet | Meşide Gündüzöz Ceylan Bal Murat Büyükşekerci Salim Neşelioğlu Türkan Nadir Öziş Servet İritaş Halil Kara Özcan Erel |
| author_sort | Meşide Gündüzöz |
| collection | DOAJ |
| description | Background: Oxidative stress is implicated as one of the main molecular mechanism underlying silicosis.
Aims: In this study, our aim was to asses the redox status in occupationally silica-exposed workers, by evaluating the dynamic thiol-disulphide homeostasis.
Study Design: Case-control study.
Methods: Thirty-six male workers occupationally exposed to silica particles and 30 healthy volunteers, working as office workers were included to the study. Posteroanterior chest radiographs and pulmonary function tests of both groups were evaluated. Also serum thiol disulphide levels were measured using the spectrophotometric method described by Erel and Neşelioğlu.
Results: Among the 36 workers that underwent pulmonary function tests 6 (17%) had obstructive, 7 (19%) had restrictive, 6 (17%) had obstructive and restrictive signs whereas 17 (47%) had no signs. The mean PFTs results of silica-exposed workers were significantly lower than control subjects. The serum disulphide levels of silica-exposed workers were significantly higher than control subjects (23.84±5.89 μmol/L and 21.18±3.44 μmol/L, respectively p=0.02).
Conclusion: The serum disulphide levels, a biomarker of oxidative stress, are found to be higher in silica-exposed workers |
| first_indexed | 2024-04-10T10:12:12Z |
| format | Article |
| id | doaj.art-36a28de11bba45598806d3b11b1482ed |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T10:12:12Z |
| publishDate | 2017-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-36a28de11bba45598806d3b11b1482ed2023-02-15T16:22:06ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312017-04-0134210210710.4274/balkanmedj.2015.1632Evaluation of Dynamic Disulphide/Thiol Homeostasis in Silica Exposed WorkersMeşide Gündüzöz0Ceylan Bal1Murat Büyükşekerci2Salim Neşelioğlu3Türkan Nadir Öziş4Servet İritaş5Halil Kara6Özcan Erel7Clinic of Family Medicine, Ankara Occupational Diseases Hospital, Ankara, TurkeyDepartment of Biochemistry, Yıldırım Beyazıt University School of Medicine, Ankara, TurkeyClinic of Pharmacology, Ankara Occupational Diseases Hospital, Ankara, TurkeyDepartment of Biochemistry, Yıldırım Beyazıt University School of Medicine, Ankara, TurkeyClinic of Chest Diseases, Ankara Occupational Diseases Hospital, Ankara, TurkeyDepartment of Toxicology, The Council of Forensic Medicine, Ankara, TurkeyDepartment of Pharmacology, Yıldırım Beyazıt University School of Medicine, Ankara, TurkeyDepartment of Biochemistry, Yıldırım Beyazıt University School of Medicine, Ankara, TurkeyBackground: Oxidative stress is implicated as one of the main molecular mechanism underlying silicosis. Aims: In this study, our aim was to asses the redox status in occupationally silica-exposed workers, by evaluating the dynamic thiol-disulphide homeostasis. Study Design: Case-control study. Methods: Thirty-six male workers occupationally exposed to silica particles and 30 healthy volunteers, working as office workers were included to the study. Posteroanterior chest radiographs and pulmonary function tests of both groups were evaluated. Also serum thiol disulphide levels were measured using the spectrophotometric method described by Erel and Neşelioğlu. Results: Among the 36 workers that underwent pulmonary function tests 6 (17%) had obstructive, 7 (19%) had restrictive, 6 (17%) had obstructive and restrictive signs whereas 17 (47%) had no signs. The mean PFTs results of silica-exposed workers were significantly lower than control subjects. The serum disulphide levels of silica-exposed workers were significantly higher than control subjects (23.84±5.89 μmol/L and 21.18±3.44 μmol/L, respectively p=0.02). Conclusion: The serum disulphide levels, a biomarker of oxidative stress, are found to be higher in silica-exposed workershttp://balkanmedicaljournal.org/text.php?lang=en&id=1798Disulphidethioloxidative stresssilicaexposure |
| spellingShingle | Meşide Gündüzöz Ceylan Bal Murat Büyükşekerci Salim Neşelioğlu Türkan Nadir Öziş Servet İritaş Halil Kara Özcan Erel Evaluation of Dynamic Disulphide/Thiol Homeostasis in Silica Exposed Workers Balkan Medical Journal Disulphide thiol oxidative stress silica exposure |
| title | Evaluation of Dynamic Disulphide/Thiol Homeostasis in Silica Exposed Workers |
| title_full | Evaluation of Dynamic Disulphide/Thiol Homeostasis in Silica Exposed Workers |
| title_fullStr | Evaluation of Dynamic Disulphide/Thiol Homeostasis in Silica Exposed Workers |
| title_full_unstemmed | Evaluation of Dynamic Disulphide/Thiol Homeostasis in Silica Exposed Workers |
| title_short | Evaluation of Dynamic Disulphide/Thiol Homeostasis in Silica Exposed Workers |
| title_sort | evaluation of dynamic disulphide thiol homeostasis in silica exposed workers |
| topic | Disulphide thiol oxidative stress silica exposure |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=1798 |
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