DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer

Altered epigenetics is a feature of cancer but whether these changes occur early in tumour development is unclear. Here, the authors analyse methylation events in breast cancer and adjacent normal pairs, and show that methylation changes in the normal tissue are also found in the tumour, suggesting...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Andrew E Teschendorff, Yang Gao, Allison Jones, Matthias Ruebner, Matthias W. Beckmann, David L. Wachter, Peter A. Fasching, Martin Widschwendter
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: Nature Portfolio 2016-01-01
Цуврал:Nature Communications
Онлайн хандалт:https://doi.org/10.1038/ncomms10478