Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats
Abstract The association of exertional heat stroke (EHS) and testicular morphological changes affecting sperm quality, as well as the association of EHS and hypothalamic changes affecting sexual behavior, has yet to be elucidated. This study aimed to elucidate the effects of EHS on fertility, erecti...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-83121-3 |
| _version_ | 1818841758956519424 |
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| author | Pei-Hsuan Lin Kuan-Hua Huang Yu-Feng Tian Cheng-Hsien Lin Chien-Ming Chao Ling-Yu Tang Kun-Lin Hsieh Ching-Ping Chang |
| author_facet | Pei-Hsuan Lin Kuan-Hua Huang Yu-Feng Tian Cheng-Hsien Lin Chien-Ming Chao Ling-Yu Tang Kun-Lin Hsieh Ching-Ping Chang |
| author_sort | Pei-Hsuan Lin |
| collection | DOAJ |
| description | Abstract The association of exertional heat stroke (EHS) and testicular morphological changes affecting sperm quality, as well as the association of EHS and hypothalamic changes affecting sexual behavior, has yet to be elucidated. This study aimed to elucidate the effects of EHS on fertility, erectile function, and testicular morphology in male rats. Animals were exercised at higher room temperature (36 ℃ relative humidity 50%) to induce EHS, characterized by excessive hyperthermia, neurobehavioral deficits, hypothalamic cell damage, systemic inflammation, coagulopathy, and multiple organ injury. In particular, EHS animals had erectile dysfunction (as determined by measuring the changes of intracavernosal pressure and mean arterial pressure in response to electrical stimulation of cavernous nerves). Rats also displayed testicular temperature disruption, poorly differentiated seminiferous tubules, impaired sperm quality, and atrophy of interstitial Leydig cells, Sertoli cells, and peri-tubular cells in the testicular tissues accompanied by no spermatozoa and broken cells with pyknosis in their seminal vesicle and prostatitis. These EHS effects were still observed after 3 days following EHS onset, at least. Our findings provide a greater understanding of the effect of experimentally induced EHS on masculine sexual behavior, fertility, stress hormones, and morphology of both testis and prostate. |
| first_indexed | 2024-12-19T04:31:11Z |
| format | Article |
| id | doaj.art-36a320af95a34ae7bc9188120deb8096 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T04:31:11Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-36a320af95a34ae7bc9188120deb80962022-12-21T20:35:52ZengNature PortfolioScientific Reports2045-23222021-02-0111111410.1038/s41598-021-83121-3Exertional heat stroke on fertility, erectile function, and testicular morphology in male ratsPei-Hsuan Lin0Kuan-Hua Huang1Yu-Feng Tian2Cheng-Hsien Lin3Chien-Ming Chao4Ling-Yu Tang5Kun-Lin Hsieh6Ching-Ping Chang7Department of Obstetrics and Gynecology, Da-An Women and Children HospitalDivision of Urology, Department of Surgery, Chi-Mei Medical CenterDivision of Colorectal Surgery, Department of Surgery, Chi Mei Medical CenterDepartment of Medicine, Mackay Medical CollegeDepartment of Intensive Care Medicine, Chi Mei Medical CenterDepartment of Medical Research, Chi Mei Medical CenterDivision of Urology, Department of Surgery, Chi-Mei Medical CenterDepartment of Medical Research, Chi Mei Medical CenterAbstract The association of exertional heat stroke (EHS) and testicular morphological changes affecting sperm quality, as well as the association of EHS and hypothalamic changes affecting sexual behavior, has yet to be elucidated. This study aimed to elucidate the effects of EHS on fertility, erectile function, and testicular morphology in male rats. Animals were exercised at higher room temperature (36 ℃ relative humidity 50%) to induce EHS, characterized by excessive hyperthermia, neurobehavioral deficits, hypothalamic cell damage, systemic inflammation, coagulopathy, and multiple organ injury. In particular, EHS animals had erectile dysfunction (as determined by measuring the changes of intracavernosal pressure and mean arterial pressure in response to electrical stimulation of cavernous nerves). Rats also displayed testicular temperature disruption, poorly differentiated seminiferous tubules, impaired sperm quality, and atrophy of interstitial Leydig cells, Sertoli cells, and peri-tubular cells in the testicular tissues accompanied by no spermatozoa and broken cells with pyknosis in their seminal vesicle and prostatitis. These EHS effects were still observed after 3 days following EHS onset, at least. Our findings provide a greater understanding of the effect of experimentally induced EHS on masculine sexual behavior, fertility, stress hormones, and morphology of both testis and prostate.https://doi.org/10.1038/s41598-021-83121-3 |
| spellingShingle | Pei-Hsuan Lin Kuan-Hua Huang Yu-Feng Tian Cheng-Hsien Lin Chien-Ming Chao Ling-Yu Tang Kun-Lin Hsieh Ching-Ping Chang Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats Scientific Reports |
| title | Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats |
| title_full | Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats |
| title_fullStr | Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats |
| title_full_unstemmed | Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats |
| title_short | Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats |
| title_sort | exertional heat stroke on fertility erectile function and testicular morphology in male rats |
| url | https://doi.org/10.1038/s41598-021-83121-3 |
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