MOTS-c Functionally Prevents Metabolic Disorders
Mitochondrial-derived peptides are a family of peptides encoded by short open reading frames in the mitochondrial genome, which have regulatory effects on mitochondrial functions, gene expression, and metabolic homeostasis of the body. As a new member of the mitochondrial-derived peptide family, mit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/1/125 |
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| author | Yue Gao Xinran Wei Pingying Wei Huijie Lu Luying Zhong Jie Tan Hongbo Liu Zheng Liu |
| author_facet | Yue Gao Xinran Wei Pingying Wei Huijie Lu Luying Zhong Jie Tan Hongbo Liu Zheng Liu |
| author_sort | Yue Gao |
| collection | DOAJ |
| description | Mitochondrial-derived peptides are a family of peptides encoded by short open reading frames in the mitochondrial genome, which have regulatory effects on mitochondrial functions, gene expression, and metabolic homeostasis of the body. As a new member of the mitochondrial-derived peptide family, mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is regarding a peptide hormone that could reduce insulin resistance, prevent obesity, improve muscle function, promote bone metabolism, enhance immune regulation, and postpone aging. MOTS-c plays these physiological functions mainly through activating the AICAR-AMPK signaling pathways by disrupting the folate-methionine cycle in cells. Recent studies have shown that the above hormonal effect can be achieved through MOTS-c regulating the expression of genes such as GLUT4, STAT3, and IL-10. However, there is a lack of articles summarizing the genes and pathways involved in the physiological activity of MOTS-c. This article aims to summarize and interpret the interesting and updated findings of MOTS-c-associated genes and pathways involved in pathological metabolic processes. Finally, it is expected to develop novel diagnostic markers and treatment approaches with MOTS-c to prevent and treat metabolic disorders in the future. |
| first_indexed | 2024-03-09T11:42:17Z |
| format | Article |
| id | doaj.art-36a3337ab42e4a24bafef954d44587cd |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T11:42:17Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-36a3337ab42e4a24bafef954d44587cd2023-11-30T23:29:20ZengMDPI AGMetabolites2218-19892023-01-0113112510.3390/metabo13010125MOTS-c Functionally Prevents Metabolic DisordersYue Gao0Xinran Wei1Pingying Wei2Huijie Lu3Luying Zhong4Jie Tan5Hongbo Liu6Zheng Liu7College of Medical Laboratory Science, Guilin Medical University, Guilin 541004, ChinaCollege of Medical Laboratory Science, Guilin Medical University, Guilin 541004, ChinaCollege of Medical Laboratory Science, Guilin Medical University, Guilin 541004, ChinaCollege of Medical Laboratory Science, Guilin Medical University, Guilin 541004, ChinaCollege of Medical Laboratory Science, Guilin Medical University, Guilin 541004, ChinaGuangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin 541199, ChinaDepartment of Laboratory Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, ChinaCollege of Medical Laboratory Science, Guilin Medical University, Guilin 541004, ChinaMitochondrial-derived peptides are a family of peptides encoded by short open reading frames in the mitochondrial genome, which have regulatory effects on mitochondrial functions, gene expression, and metabolic homeostasis of the body. As a new member of the mitochondrial-derived peptide family, mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is regarding a peptide hormone that could reduce insulin resistance, prevent obesity, improve muscle function, promote bone metabolism, enhance immune regulation, and postpone aging. MOTS-c plays these physiological functions mainly through activating the AICAR-AMPK signaling pathways by disrupting the folate-methionine cycle in cells. Recent studies have shown that the above hormonal effect can be achieved through MOTS-c regulating the expression of genes such as GLUT4, STAT3, and IL-10. However, there is a lack of articles summarizing the genes and pathways involved in the physiological activity of MOTS-c. This article aims to summarize and interpret the interesting and updated findings of MOTS-c-associated genes and pathways involved in pathological metabolic processes. Finally, it is expected to develop novel diagnostic markers and treatment approaches with MOTS-c to prevent and treat metabolic disorders in the future.https://www.mdpi.com/2218-1989/13/1/125MOTS-cinsulin resistanceobesitymuscle functionbone metabolismimmune regulation |
| spellingShingle | Yue Gao Xinran Wei Pingying Wei Huijie Lu Luying Zhong Jie Tan Hongbo Liu Zheng Liu MOTS-c Functionally Prevents Metabolic Disorders Metabolites MOTS-c insulin resistance obesity muscle function bone metabolism immune regulation |
| title | MOTS-c Functionally Prevents Metabolic Disorders |
| title_full | MOTS-c Functionally Prevents Metabolic Disorders |
| title_fullStr | MOTS-c Functionally Prevents Metabolic Disorders |
| title_full_unstemmed | MOTS-c Functionally Prevents Metabolic Disorders |
| title_short | MOTS-c Functionally Prevents Metabolic Disorders |
| title_sort | mots c functionally prevents metabolic disorders |
| topic | MOTS-c insulin resistance obesity muscle function bone metabolism immune regulation |
| url | https://www.mdpi.com/2218-1989/13/1/125 |
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