Comparative analysis of hemostatic disorders in bacterial and viral neuroinfections at a children
Purulent meningitis and viral encephalitis are the most common neuroinfections in children. The severity of the lesion, the frequency of disabling manifestations, as well as high mortality, determine the relevance of their study. Violations of hemostasis both in purulent meningitis and in viral ence...
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| Format: | Article |
| Language: | Russian |
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LLC "Diagnostics and Vaccines"
2020-06-01
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| Series: | Детские инфекции (Москва) |
| Subjects: | |
| Online Access: | https://detinf.elpub.ru/jour/article/view/500 |
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| author | E. S. Egorova N. V. Skripchenko А. А. Vilnits L. A. Alekseeva E. Yu. Skripchenko |
| author_facet | E. S. Egorova N. V. Skripchenko А. А. Vilnits L. A. Alekseeva E. Yu. Skripchenko |
| author_sort | E. S. Egorova |
| collection | DOAJ |
| description | Purulent meningitis and viral encephalitis are the most common neuroinfections in children. The severity of the lesion, the frequency of disabling manifestations, as well as high mortality, determine the relevance of their study. Violations of hemostasis both in purulent meningitis and in viral encephalitis are some of the important pathogenetic mechanisms that determine the nature of the course and the similarity of the disease. The material for clinical, laboratory, and radiation studies was 100 children with purulent meningitis of various etiologies and viral encephalitis from the age of 1 month to 17 years 11 months. In addition to clinical monitoring, all patients underwent D-dimer and circulating endotheliocytes in the acute period and disease dynamics. The different nature of vascular damage has been proved: with the prevalence of endothelial damage in purulent meningitis, and a violation of its functional activity with vascular tone dysfunction — in case of viral encephalitis. Radiation markers of cerebral vascular damage in the acute period of neuroinfections are described. The pathogenetic significance of structural and functional disorders of the vascular wall and hemostasis in the genesis of purulent meningitis and viral encephalitis in children has been established. |
| first_indexed | 2024-04-10T03:25:16Z |
| format | Article |
| id | doaj.art-36a38b3047b243b48a9728835bee1ad0 |
| institution | Directory Open Access Journal |
| issn | 2072-8107 |
| language | Russian |
| last_indexed | 2024-04-10T03:25:16Z |
| publishDate | 2020-06-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj.art-36a38b3047b243b48a9728835bee1ad02023-03-13T07:28:25ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072020-06-0119251310.22627/2072-8107-2020-19-2-5-13444Comparative analysis of hemostatic disorders in bacterial and viral neuroinfections at a childrenE. S. Egorova0N. V. Skripchenko1А. А. Vilnits2L. A. Alekseeva3E. Yu. Skripchenko4Детский научно-клинический центр инфекционных болезней ФМБА РоссииДетский научно-клинический центр инфекционных болезней ФМБА России; Cанкт-Петербургский государственный педиатрический медицинский университетДетский научно-клинический центр инфекционных болезней ФМБА России; Cанкт-Петербургский государственный педиатрический медицинский университетДетский научно-клинический центр инфекционных болезней ФМБА РоссииДетский научно-клинический центр инфекционных болезней ФМБА России; Cанкт-Петербургский государственный педиатрический медицинский университетPurulent meningitis and viral encephalitis are the most common neuroinfections in children. The severity of the lesion, the frequency of disabling manifestations, as well as high mortality, determine the relevance of their study. Violations of hemostasis both in purulent meningitis and in viral encephalitis are some of the important pathogenetic mechanisms that determine the nature of the course and the similarity of the disease. The material for clinical, laboratory, and radiation studies was 100 children with purulent meningitis of various etiologies and viral encephalitis from the age of 1 month to 17 years 11 months. In addition to clinical monitoring, all patients underwent D-dimer and circulating endotheliocytes in the acute period and disease dynamics. The different nature of vascular damage has been proved: with the prevalence of endothelial damage in purulent meningitis, and a violation of its functional activity with vascular tone dysfunction — in case of viral encephalitis. Radiation markers of cerebral vascular damage in the acute period of neuroinfections are described. The pathogenetic significance of structural and functional disorders of the vascular wall and hemostasis in the genesis of purulent meningitis and viral encephalitis in children has been established.https://detinf.elpub.ru/jour/article/view/500детигнойный менингитвирусный энцефалитнарушения гемостазаваскулитд-димерциркулирующие эндотелиоциты |
| spellingShingle | E. S. Egorova N. V. Skripchenko А. А. Vilnits L. A. Alekseeva E. Yu. Skripchenko Comparative analysis of hemostatic disorders in bacterial and viral neuroinfections at a children Детские инфекции (Москва) дети гнойный менингит вирусный энцефалит нарушения гемостаза васкулит д-димер циркулирующие эндотелиоциты |
| title | Comparative analysis of hemostatic disorders in bacterial and viral neuroinfections at a children |
| title_full | Comparative analysis of hemostatic disorders in bacterial and viral neuroinfections at a children |
| title_fullStr | Comparative analysis of hemostatic disorders in bacterial and viral neuroinfections at a children |
| title_full_unstemmed | Comparative analysis of hemostatic disorders in bacterial and viral neuroinfections at a children |
| title_short | Comparative analysis of hemostatic disorders in bacterial and viral neuroinfections at a children |
| title_sort | comparative analysis of hemostatic disorders in bacterial and viral neuroinfections at a children |
| topic | дети гнойный менингит вирусный энцефалит нарушения гемостаза васкулит д-димер циркулирующие эндотелиоциты |
| url | https://detinf.elpub.ru/jour/article/view/500 |
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