PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

We recently reported that the inward-rectifier Kir2.1 channel in brain capillary endothelial cells (cECs) plays a major role in neurovascular coupling (NVC) by mediating a neuronal activity-dependent, propagating vasodilatory (hyperpolarizing) signal. We further demonstrated that Kir2.1 activity is...

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Bibliographic Details
Main Authors: Osama F Harraz, Thomas A Longden, David Hill-Eubanks, Mark T Nelson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
TRPV4
neurovascular coupling
PIP2
Kir2.1
GPCR
brain capillaries
Online Access:https://elifesciences.org/articles/38689

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