Myocardial Ischemia Related to Common Cancer Therapy—Prevention Insights
Modern antineoplastic therapy improves survival and quality of life in cancer patients, but its indisputable benefits are accompanied by multiple and major side effects, such as cardiovascular ones. Endothelial dysfunction, arterial spasm, intravascular thrombosis, and accelerated atherosclerosis af...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/7/1034 |
| _version_ | 1797405821248733184 |
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| author | Minerva Codruta Badescu Oana Viola Badulescu Dragos Viorel Scripcariu Lăcrămioara Ionela Butnariu Iris Bararu-Bojan Diana Popescu Manuela Ciocoiu Eusebiu Vlad Gorduza Irina Iuliana Costache Elena Rezus Ciprian Rezus |
| author_facet | Minerva Codruta Badescu Oana Viola Badulescu Dragos Viorel Scripcariu Lăcrămioara Ionela Butnariu Iris Bararu-Bojan Diana Popescu Manuela Ciocoiu Eusebiu Vlad Gorduza Irina Iuliana Costache Elena Rezus Ciprian Rezus |
| author_sort | Minerva Codruta Badescu |
| collection | DOAJ |
| description | Modern antineoplastic therapy improves survival and quality of life in cancer patients, but its indisputable benefits are accompanied by multiple and major side effects, such as cardiovascular ones. Endothelial dysfunction, arterial spasm, intravascular thrombosis, and accelerated atherosclerosis affect the coronary arteries, leading to acute and chronic coronary syndromes that negatively interfere with the oncologic treatment. The cardiac toxicity of antineoplastic agents may be mitigated by using adequate prophylactic measures. In the absence of dedicated guidelines, our work provides the most comprehensive, systematized, structured, and up-to-date analyses of the available literature focusing on measures aiming to protect the coronary arteries from the toxicity of cancer therapy. Our work facilitates the implementation of these measures in daily practice. The ultimate goal is to offer clinicians the necessary data for a personalized therapeutic approach for cancer patients receiving evidence-based oncology treatments with potential cardiovascular toxicity. |
| first_indexed | 2024-03-09T03:16:46Z |
| format | Article |
| id | doaj.art-36a3a0e4cd9b4602b8243e1aff1bf104 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T03:16:46Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-36a3a0e4cd9b4602b8243e1aff1bf1042023-12-03T15:18:46ZengMDPI AGLife2075-17292022-07-01127103410.3390/life12071034Myocardial Ischemia Related to Common Cancer Therapy—Prevention InsightsMinerva Codruta Badescu0Oana Viola Badulescu1Dragos Viorel Scripcariu2Lăcrămioara Ionela Butnariu3Iris Bararu-Bojan4Diana Popescu5Manuela Ciocoiu6Eusebiu Vlad Gorduza7Irina Iuliana Costache8Elena Rezus9Ciprian Rezus10Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, RomaniaDepartment of Pathophysiology, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, RomaniaSurgery Department, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, RomaniaDepartment of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Pathophysiology, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, RomaniaDepartment of Pathophysiology, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, RomaniaDepartment of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, RomaniaDepartment of Rheumatology and Physiotherapy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, RomaniaModern antineoplastic therapy improves survival and quality of life in cancer patients, but its indisputable benefits are accompanied by multiple and major side effects, such as cardiovascular ones. Endothelial dysfunction, arterial spasm, intravascular thrombosis, and accelerated atherosclerosis affect the coronary arteries, leading to acute and chronic coronary syndromes that negatively interfere with the oncologic treatment. The cardiac toxicity of antineoplastic agents may be mitigated by using adequate prophylactic measures. In the absence of dedicated guidelines, our work provides the most comprehensive, systematized, structured, and up-to-date analyses of the available literature focusing on measures aiming to protect the coronary arteries from the toxicity of cancer therapy. Our work facilitates the implementation of these measures in daily practice. The ultimate goal is to offer clinicians the necessary data for a personalized therapeutic approach for cancer patients receiving evidence-based oncology treatments with potential cardiovascular toxicity.https://www.mdpi.com/2075-1729/12/7/1034accelerated atherosclerosiscoronary spasmcoronary thrombosisendothelial dysfunctioncancerprevention |
| spellingShingle | Minerva Codruta Badescu Oana Viola Badulescu Dragos Viorel Scripcariu Lăcrămioara Ionela Butnariu Iris Bararu-Bojan Diana Popescu Manuela Ciocoiu Eusebiu Vlad Gorduza Irina Iuliana Costache Elena Rezus Ciprian Rezus Myocardial Ischemia Related to Common Cancer Therapy—Prevention Insights Life accelerated atherosclerosis coronary spasm coronary thrombosis endothelial dysfunction cancer prevention |
| title | Myocardial Ischemia Related to Common Cancer Therapy—Prevention Insights |
| title_full | Myocardial Ischemia Related to Common Cancer Therapy—Prevention Insights |
| title_fullStr | Myocardial Ischemia Related to Common Cancer Therapy—Prevention Insights |
| title_full_unstemmed | Myocardial Ischemia Related to Common Cancer Therapy—Prevention Insights |
| title_short | Myocardial Ischemia Related to Common Cancer Therapy—Prevention Insights |
| title_sort | myocardial ischemia related to common cancer therapy prevention insights |
| topic | accelerated atherosclerosis coronary spasm coronary thrombosis endothelial dysfunction cancer prevention |
| url | https://www.mdpi.com/2075-1729/12/7/1034 |
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