Analysis of fatality impact and seroprevalence surveys in a community sustaining a SARS-CoV-2 superspreading event
Abstract There is an ongoing debate on the COVID-19 infection fatality rate (IFR) and the impact of COVID-19 on overall population mortality. Here, we addressed these issues in a community in Germany with a major superspreader event analyzing deaths over time and auditing death certificates in the c...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32441-7 |
| _version_ | 1797850087318093824 |
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| author | Enrico Richter Dominik Liebl Bianca Schulte Nils Lehmann Christine Fuhrmann Karl-Heinz Jöckel John P. A. Ioannidis Hendrik Streeck |
| author_facet | Enrico Richter Dominik Liebl Bianca Schulte Nils Lehmann Christine Fuhrmann Karl-Heinz Jöckel John P. A. Ioannidis Hendrik Streeck |
| author_sort | Enrico Richter |
| collection | DOAJ |
| description | Abstract There is an ongoing debate on the COVID-19 infection fatality rate (IFR) and the impact of COVID-19 on overall population mortality. Here, we addressed these issues in a community in Germany with a major superspreader event analyzing deaths over time and auditing death certificates in the community.18 deaths that occurred within the first six months of the pandemic had a positive test for SARS-CoV-2. Six out of 18 deaths had non-COVID-19 related causes of death (COD). Individuals with COVID-19 COD typically died of respiratory failure (75%) and tended to have fewer reported comorbidities (p = 0.029). Duration between first confirmed infection and death was negatively associated with COVID-19 being COD (p = 0.04). Repeated seroprevalence essays in a cross-sectional epidemiological study showed modest increases in seroprevalence over time, and substantial seroreversion (30%). IFR estimates accordingly varied depending on COVID-19 death attribution. Careful ascertainment of COVID-19 deaths is important in understanding the impact of the pandemic. |
| first_indexed | 2024-04-09T18:54:42Z |
| format | Article |
| id | doaj.art-36a5eba8970642059f0dd9443d25be98 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T18:54:42Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-36a5eba8970642059f0dd9443d25be982023-04-09T11:15:02ZengNature PortfolioScientific Reports2045-23222023-04-0113111310.1038/s41598-023-32441-7Analysis of fatality impact and seroprevalence surveys in a community sustaining a SARS-CoV-2 superspreading eventEnrico Richter0Dominik Liebl1Bianca Schulte2Nils Lehmann3Christine Fuhrmann4Karl-Heinz Jöckel5John P. A. Ioannidis6Hendrik Streeck7Institute of Virology, University Hospital, University of BonnInstitute of Finance and Statistics and Hausdorff Center for Mathematics, University of BonnInstitute of Virology, University Hospital, University of BonnInstitute of Medical Informatics, Biometry und Epidemiology (IMIBE), University Hospital EssenClinical Study Core Unit, Study Center Bonn (SZB), Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital BonnInstitute of Medical Informatics, Biometry und Epidemiology (IMIBE), University Hospital EssenDepartments of Medicine, of Epidemiology and Population Health, of Biomedical Data Science, and of Statistics, Stanford UniversityInstitute of Virology, University Hospital, University of BonnAbstract There is an ongoing debate on the COVID-19 infection fatality rate (IFR) and the impact of COVID-19 on overall population mortality. Here, we addressed these issues in a community in Germany with a major superspreader event analyzing deaths over time and auditing death certificates in the community.18 deaths that occurred within the first six months of the pandemic had a positive test for SARS-CoV-2. Six out of 18 deaths had non-COVID-19 related causes of death (COD). Individuals with COVID-19 COD typically died of respiratory failure (75%) and tended to have fewer reported comorbidities (p = 0.029). Duration between first confirmed infection and death was negatively associated with COVID-19 being COD (p = 0.04). Repeated seroprevalence essays in a cross-sectional epidemiological study showed modest increases in seroprevalence over time, and substantial seroreversion (30%). IFR estimates accordingly varied depending on COVID-19 death attribution. Careful ascertainment of COVID-19 deaths is important in understanding the impact of the pandemic.https://doi.org/10.1038/s41598-023-32441-7 |
| spellingShingle | Enrico Richter Dominik Liebl Bianca Schulte Nils Lehmann Christine Fuhrmann Karl-Heinz Jöckel John P. A. Ioannidis Hendrik Streeck Analysis of fatality impact and seroprevalence surveys in a community sustaining a SARS-CoV-2 superspreading event Scientific Reports |
| title | Analysis of fatality impact and seroprevalence surveys in a community sustaining a SARS-CoV-2 superspreading event |
| title_full | Analysis of fatality impact and seroprevalence surveys in a community sustaining a SARS-CoV-2 superspreading event |
| title_fullStr | Analysis of fatality impact and seroprevalence surveys in a community sustaining a SARS-CoV-2 superspreading event |
| title_full_unstemmed | Analysis of fatality impact and seroprevalence surveys in a community sustaining a SARS-CoV-2 superspreading event |
| title_short | Analysis of fatality impact and seroprevalence surveys in a community sustaining a SARS-CoV-2 superspreading event |
| title_sort | analysis of fatality impact and seroprevalence surveys in a community sustaining a sars cov 2 superspreading event |
| url | https://doi.org/10.1038/s41598-023-32441-7 |
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