Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate
Low fertilization rate (LFR) and total fertilization failure (TFF) are often encountered in routine in vitro fertilization (IVF) procedure. To solve this problem, multivariate analyses on the relationship between male factors and in vitro fertilization rate were performed, and a nomogram for predict...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024053027 |
| _version_ | 1827288756773715968 |
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| author | Mengyuan Lin Yuwei Zhang Honghua Wang Yan Wang Yang Wang Ninghan Feng Qingwen He |
| author_facet | Mengyuan Lin Yuwei Zhang Honghua Wang Yan Wang Yang Wang Ninghan Feng Qingwen He |
| author_sort | Mengyuan Lin |
| collection | DOAJ |
| description | Low fertilization rate (LFR) and total fertilization failure (TFF) are often encountered in routine in vitro fertilization (IVF) procedure. To solve this problem, multivariate analyses on the relationship between male factors and in vitro fertilization rate were performed, and a nomogram for prediction of LFR was constructed. This retrospective study contained 2011 couples who received IVF treatment from January 2017 to December 2021. Man factors and in vitro fertilization rate were collected. Among these couples, 1347 cases had in vitro fertilization rates ≥30 % (control group), and 664 cases had in vitro fertilization rates <30 % (LFR group). Univariate analyses of male factors found that between the two groups there were significant differences (p < 0.05) in sperm progressive motility (SPR), sperm concentration (SC), total sperm number, normal sperm morphology rate (NSMR), DNA fragmentation index (DFI), sperm acrosin activity (SAA) and the clinical diagnosis of primary or secondary infertility. Multivariate logistic regression analyses showed that SPR, SAA, and SC were independent risk factors for LFR. An algorithm and a correspondent nomogram for predicting high LFR risk were constructed using data from the training cohort. The LFR nomogram exhibited an excellent discrimination power and a high fitting degree in both the training cohort (AUC = 0.90, 95 % CI: 0.88–0.92), (H-L: x2 = 5.43, p = 0.71) and validation cohort (AUC = 0.89, 95 % CI:0.87–0.92), (H-L: x2 = 7.85, p = 0.45), respectively. The decision curve analysis (DCA) demonstrated a high efficiency of the LFR nomogram for clinical utility. SPR, SAA, and SC are independent risk factors for LFR. The LFR nomogram established based on these factors could be a useful tool to predict high risk of LFR, and patients with high risk of LFR can be guided to direct ICSI procedure. Clinical application of the LFR nomogram may increase the in vitro fertilization rate by facilitating the decision making in IVF service. |
| first_indexed | 2024-04-24T11:37:05Z |
| format | Article |
| id | doaj.art-36a6cf4481d9415083d10b7a71d2c6dc |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T11:37:05Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-36a6cf4481d9415083d10b7a71d2c6dc2024-04-10T04:29:17ZengElsevierHeliyon2405-84402024-04-01107e29271Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rateMengyuan Lin0Yuwei Zhang1Honghua Wang2Yan Wang3Yang Wang4Ninghan Feng5Qingwen He6Center of Reproductive Medicine, Women's Hospital of Jiangnan University, Wuxi, Jiangsu, China; Wuxi School of Medicine, Jiangnan University, Wuxi, ChinaMedical School of Nantong University, Nantong, ChinaCenter of Reproductive Medicine, Women's Hospital of Jiangnan University, Wuxi, Jiangsu, ChinaCenter of Reproductive Medicine, Women's Hospital of Jiangnan University, Wuxi, Jiangsu, ChinaDepartment of Urology, Jiangnan University Medical Center, Wuxi, ChinaWuxi School of Medicine, Jiangnan University, Wuxi, China; Department of Urology, Jiangnan University Medical Center, Wuxi, China; Corresponding author. Jiangnan University Medical Center, China.Department of Public Health, Women's Hospital of Jiangnan University, Wuxi, Jiangsu, China; Corresponding author.Low fertilization rate (LFR) and total fertilization failure (TFF) are often encountered in routine in vitro fertilization (IVF) procedure. To solve this problem, multivariate analyses on the relationship between male factors and in vitro fertilization rate were performed, and a nomogram for prediction of LFR was constructed. This retrospective study contained 2011 couples who received IVF treatment from January 2017 to December 2021. Man factors and in vitro fertilization rate were collected. Among these couples, 1347 cases had in vitro fertilization rates ≥30 % (control group), and 664 cases had in vitro fertilization rates <30 % (LFR group). Univariate analyses of male factors found that between the two groups there were significant differences (p < 0.05) in sperm progressive motility (SPR), sperm concentration (SC), total sperm number, normal sperm morphology rate (NSMR), DNA fragmentation index (DFI), sperm acrosin activity (SAA) and the clinical diagnosis of primary or secondary infertility. Multivariate logistic regression analyses showed that SPR, SAA, and SC were independent risk factors for LFR. An algorithm and a correspondent nomogram for predicting high LFR risk were constructed using data from the training cohort. The LFR nomogram exhibited an excellent discrimination power and a high fitting degree in both the training cohort (AUC = 0.90, 95 % CI: 0.88–0.92), (H-L: x2 = 5.43, p = 0.71) and validation cohort (AUC = 0.89, 95 % CI:0.87–0.92), (H-L: x2 = 7.85, p = 0.45), respectively. The decision curve analysis (DCA) demonstrated a high efficiency of the LFR nomogram for clinical utility. SPR, SAA, and SC are independent risk factors for LFR. The LFR nomogram established based on these factors could be a useful tool to predict high risk of LFR, and patients with high risk of LFR can be guided to direct ICSI procedure. Clinical application of the LFR nomogram may increase the in vitro fertilization rate by facilitating the decision making in IVF service.http://www.sciencedirect.com/science/article/pii/S2405844024053027Multivariate analysesNomogramIn vitro fertilizationLow fertilization rate |
| spellingShingle | Mengyuan Lin Yuwei Zhang Honghua Wang Yan Wang Yang Wang Ninghan Feng Qingwen He Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate Heliyon Multivariate analyses Nomogram In vitro fertilization Low fertilization rate |
| title | Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate |
| title_full | Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate |
| title_fullStr | Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate |
| title_full_unstemmed | Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate |
| title_short | Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate |
| title_sort | multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate |
| topic | Multivariate analyses Nomogram In vitro fertilization Low fertilization rate |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024053027 |
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