A Hospital Based Study on Estimation of Adenosine Deaminase Activity (ADA) in Cerebrospinal Fluid (CSF) in Various Types of Meningitis
Objective: Tuberculosis kills 3.70 lakh patients in India every year,out of which 7-12 % are meningeal involvement. Delay in its diagnosis and initiation of treatment results in poor prognosis and squeal in up to 25% of cases. The aim of the present study is to look for a simple, rapid, cost eff...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4012/23-%207154_E(Ra)_F(P)_PF1(PAK)_PFA(AK)_PF2(PAK).pdf |
| Summary: | Objective: Tuberculosis kills 3.70 lakh patients in India every
year,out of which 7-12 % are meningeal involvement. Delay in
its diagnosis and initiation of treatment results in poor prognosis
and squeal in up to 25% of cases. The aim of the present study
is to look for a simple, rapid, cost effective, and fairly specific
test in differentiating tubercular aetiology from other causes of
meningitis. In the present study we measured the adenosine
deaminase activity (ADA) in Cerebrospinal Fluid (CSF) of
Tubercular Meningitis (TBM) and non-TBM patients.
Methods: Fifty six patients attending hospital with symptoms
and signs of meningitis were selected and divided into three
groups: tubercular, pyogenic, and aseptic meningitis, depending
upon the accepted criteria. CSF was drawn and ADA estimated.
Results: Out of 32 tubercular patients, 28 had CSF-ADA at or
above the cut-off value while four had below. Out of 24 nontuberculous patients (pyogenic and aseptic meningitis), two
aseptic meningitis (AM) patient had ADA levels at or above
the cut-off value while 22 had below this value. Results of our
study indicate that ADA level estimation in CSF is not only of
considerable value in the diagnosis of TBM, CSF, and ADA level
10 U/L as a cut-off value with sensitivity 87.5% and specificity
83.33% and positive predictive value of the test was 87.5%.and
83.3% negative predictive value.
Conclusion: It can be concluded that ADA estimation in CSF
is not only simple, inexpensive and rapid but also fairly specific
method for making a diagnosis of tuberculous aetiology in
TBM, especially when there is a dilemma of differentiating the
tuberculous aetiology from non-tuberculous ones. For this
reason ADA estimation in TBM may find a place as a routine
investigation. |
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| ISSN: | 2249-782X 0973-709X |