Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery
In our study, the effect of the use of autofluorescence (Visually Enhanced Lesion Scope—VELscope) on increasing the success rate of surgical treatment in oral squamous carcinoma (OSCC) was investigated. Our hypothesis was tested on a group of 122 patients suffering from OSCC, randomized into a study...
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MDPI AG
2023-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/20/3161 |
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| author | Petr Pošta Andreas Kolk Kristýna Pivovarčíková Jan Liška Jiří Genčur Omid Moztarzadeh Christos Micopulos Adam Pěnkava Maria Frolo Oliver Bissinger Lukáš Hauer |
| author_facet | Petr Pošta Andreas Kolk Kristýna Pivovarčíková Jan Liška Jiří Genčur Omid Moztarzadeh Christos Micopulos Adam Pěnkava Maria Frolo Oliver Bissinger Lukáš Hauer |
| author_sort | Petr Pošta |
| collection | DOAJ |
| description | In our study, the effect of the use of autofluorescence (Visually Enhanced Lesion Scope—VELscope) on increasing the success rate of surgical treatment in oral squamous carcinoma (OSCC) was investigated. Our hypothesis was tested on a group of 122 patients suffering from OSCC, randomized into a study and a control group enrolled in our study after meeting the inclusion criteria. The preoperative checkup via VELscope, accompanied by the marking of the range of a loss of fluorescence in the study group, was performed before the surgery. We developed a unique mucosal tattoo marking technique for this purpose. The histopathological results after surgical treatment, i.e., the margin status, were then compared. In the study group, we achieved pathological free margin (pFM) in 55 patients, pathological close margin (pCM) in 6 cases, and we encountered no cases of pathological positive margin (pPM) in the mucosal layer. In comparison, the control group results revealed pPM in 7 cases, pCM in 14 cases, and pFM in 40 of all cases in the mucosal layer. This study demonstrated that preoperative autofluorescence assessment of the mucosal surroundings of OSCC increased the ability to achieve pFM resection 4.8 times in terms of lateral margins. |
| first_indexed | 2024-03-10T21:19:26Z |
| format | Article |
| id | doaj.art-36aa25aa172e4f6481fea737b8e080b2 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T21:19:26Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-36aa25aa172e4f6481fea737b8e080b22023-11-19T16:12:08ZengMDPI AGDiagnostics2075-44182023-10-011320316110.3390/diagnostics13203161Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma SurgeryPetr Pošta0Andreas Kolk1Kristýna Pivovarčíková2Jan Liška3Jiří Genčur4Omid Moztarzadeh5Christos Micopulos6Adam Pěnkava7Maria Frolo8Oliver Bissinger9Lukáš Hauer10Department of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech RepublicDepartment of Oral and Maxillofacial Surgery, Medical University of Innsbruck, 6020 Innsbruck, AustriaSikl’s Department of Pathology, Faculty of Medicine, Charles University, 32300 Pilsen, Czech RepublicDepartment of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech RepublicDepartment of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech RepublicDepartment of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech RepublicDepartment of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech RepublicDepartment of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech RepublicDepartment of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech RepublicDepartment of Oral and Maxillofacial Surgery, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech RepublicIn our study, the effect of the use of autofluorescence (Visually Enhanced Lesion Scope—VELscope) on increasing the success rate of surgical treatment in oral squamous carcinoma (OSCC) was investigated. Our hypothesis was tested on a group of 122 patients suffering from OSCC, randomized into a study and a control group enrolled in our study after meeting the inclusion criteria. The preoperative checkup via VELscope, accompanied by the marking of the range of a loss of fluorescence in the study group, was performed before the surgery. We developed a unique mucosal tattoo marking technique for this purpose. The histopathological results after surgical treatment, i.e., the margin status, were then compared. In the study group, we achieved pathological free margin (pFM) in 55 patients, pathological close margin (pCM) in 6 cases, and we encountered no cases of pathological positive margin (pPM) in the mucosal layer. In comparison, the control group results revealed pPM in 7 cases, pCM in 14 cases, and pFM in 40 of all cases in the mucosal layer. This study demonstrated that preoperative autofluorescence assessment of the mucosal surroundings of OSCC increased the ability to achieve pFM resection 4.8 times in terms of lateral margins.https://www.mdpi.com/2075-4418/13/20/3161autofluorescenceoral squamous cell carcinomasurgical treatmentmargin status |
| spellingShingle | Petr Pošta Andreas Kolk Kristýna Pivovarčíková Jan Liška Jiří Genčur Omid Moztarzadeh Christos Micopulos Adam Pěnkava Maria Frolo Oliver Bissinger Lukáš Hauer Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery Diagnostics autofluorescence oral squamous cell carcinoma surgical treatment margin status |
| title | Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery |
| title_full | Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery |
| title_fullStr | Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery |
| title_full_unstemmed | Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery |
| title_short | Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery |
| title_sort | clinical experience with autofluorescence guided oral squamous cell carcinoma surgery |
| topic | autofluorescence oral squamous cell carcinoma surgical treatment margin status |
| url | https://www.mdpi.com/2075-4418/13/20/3161 |
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