Depression during pregnancy and preterm delivery: a prospective cohort study among women attending antenatal clinic at Pumwani Maternity Hospital
Abstract Background Preterm birth occurs among 9.6% of births worldwide and is the leading cause of long-term neurodevelopmental disabilities among children and also responsible for 28% of neonatal deaths. No single etiological factor is responsible for preterm birth, but various risk factors have b...
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | Annals of General Psychiatry |
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| Online Access: | http://link.springer.com/article/10.1186/s12991-018-0202-6 |
| _version_ | 1818279358292295680 |
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| author | Kingi Mochache Muthoni Mathai Onesmus Gachuno Ann Vander Stoep Manasi Kumar |
| author_facet | Kingi Mochache Muthoni Mathai Onesmus Gachuno Ann Vander Stoep Manasi Kumar |
| author_sort | Kingi Mochache |
| collection | DOAJ |
| description | Abstract Background Preterm birth occurs among 9.6% of births worldwide and is the leading cause of long-term neurodevelopmental disabilities among children and also responsible for 28% of neonatal deaths. No single etiological factor is responsible for preterm birth, but various risk factors have been identified. Prior studies have reported that compromised maternal mental health occurring during pregnancy may lead to various adverse obstetric outcomes. Objective To determine whether antenatal depression is significantly associated with preterm delivery in a low resource hospital sample from the suburbs of Nairobi. Methods 292 women attending the antenatal clinic at Pumwani Maternity Hospital in Nairobi meeting the study criteria were recruited. The Edinburgh Postnatal Depression Scale was administered to screen for depression. A clinical cutoff score of 10 and above was regarded as possible depression. Thereafter, a clinical interview together with the Patient Health Questionnaire-9 was administered to evaluate the participants on DSM-V criteria for major depressive disorder. Only 255 of the women were successfully followed-up to delivery with an attrition rate of 12.7%. Records of gestation at delivery and birth weight were collected at second contact. Data analysis Preterm birth was associated with various demographic, psychosocial and medical variables. Relative risks were estimated via log binomial regression analysis to determine whether depression was a risk factor for preterm birth. Results Of the 255 participants, 98(38.4%) found to have depressive symptoms and 27(10.7%) delivered preterm. The risk of delivering preterm was 3.8 times higher among those with depressive symptoms. Conclusion There is a positive association between antenatal depression and preterm delivery. This highlights the importance of screening for mental health disorders in the antenatal period as a means to reduce adverse obstetric outcomes. |
| first_indexed | 2024-12-12T23:32:04Z |
| format | Article |
| id | doaj.art-36ac0150f11740108617e2f917048bdf |
| institution | Directory Open Access Journal |
| issn | 1744-859X |
| language | English |
| last_indexed | 2024-12-12T23:32:04Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of General Psychiatry |
| spelling | doaj.art-36ac0150f11740108617e2f917048bdf2022-12-22T00:07:43ZengBMCAnnals of General Psychiatry1744-859X2018-07-011711810.1186/s12991-018-0202-6Depression during pregnancy and preterm delivery: a prospective cohort study among women attending antenatal clinic at Pumwani Maternity HospitalKingi Mochache0Muthoni Mathai1Onesmus Gachuno2Ann Vander Stoep3Manasi Kumar4Department of Psychiatry, University of NairobiDepartment of Psychiatry, University of NairobiDept of Obstetrics and Gynecology, University of NairobiPsychiatry & Behavioral Sciences and Epidemiology, University of WashingtonDepartment of Psychiatry, University of NairobiAbstract Background Preterm birth occurs among 9.6% of births worldwide and is the leading cause of long-term neurodevelopmental disabilities among children and also responsible for 28% of neonatal deaths. No single etiological factor is responsible for preterm birth, but various risk factors have been identified. Prior studies have reported that compromised maternal mental health occurring during pregnancy may lead to various adverse obstetric outcomes. Objective To determine whether antenatal depression is significantly associated with preterm delivery in a low resource hospital sample from the suburbs of Nairobi. Methods 292 women attending the antenatal clinic at Pumwani Maternity Hospital in Nairobi meeting the study criteria were recruited. The Edinburgh Postnatal Depression Scale was administered to screen for depression. A clinical cutoff score of 10 and above was regarded as possible depression. Thereafter, a clinical interview together with the Patient Health Questionnaire-9 was administered to evaluate the participants on DSM-V criteria for major depressive disorder. Only 255 of the women were successfully followed-up to delivery with an attrition rate of 12.7%. Records of gestation at delivery and birth weight were collected at second contact. Data analysis Preterm birth was associated with various demographic, psychosocial and medical variables. Relative risks were estimated via log binomial regression analysis to determine whether depression was a risk factor for preterm birth. Results Of the 255 participants, 98(38.4%) found to have depressive symptoms and 27(10.7%) delivered preterm. The risk of delivering preterm was 3.8 times higher among those with depressive symptoms. Conclusion There is a positive association between antenatal depression and preterm delivery. This highlights the importance of screening for mental health disorders in the antenatal period as a means to reduce adverse obstetric outcomes.http://link.springer.com/article/10.1186/s12991-018-0202-6Antenatal depressionProspective cohortPreterm deliveryLow-income country |
| spellingShingle | Kingi Mochache Muthoni Mathai Onesmus Gachuno Ann Vander Stoep Manasi Kumar Depression during pregnancy and preterm delivery: a prospective cohort study among women attending antenatal clinic at Pumwani Maternity Hospital Annals of General Psychiatry Antenatal depression Prospective cohort Preterm delivery Low-income country |
| title | Depression during pregnancy and preterm delivery: a prospective cohort study among women attending antenatal clinic at Pumwani Maternity Hospital |
| title_full | Depression during pregnancy and preterm delivery: a prospective cohort study among women attending antenatal clinic at Pumwani Maternity Hospital |
| title_fullStr | Depression during pregnancy and preterm delivery: a prospective cohort study among women attending antenatal clinic at Pumwani Maternity Hospital |
| title_full_unstemmed | Depression during pregnancy and preterm delivery: a prospective cohort study among women attending antenatal clinic at Pumwani Maternity Hospital |
| title_short | Depression during pregnancy and preterm delivery: a prospective cohort study among women attending antenatal clinic at Pumwani Maternity Hospital |
| title_sort | depression during pregnancy and preterm delivery a prospective cohort study among women attending antenatal clinic at pumwani maternity hospital |
| topic | Antenatal depression Prospective cohort Preterm delivery Low-income country |
| url | http://link.springer.com/article/10.1186/s12991-018-0202-6 |
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