Association between exposure to persistent organic pollutants and pubertal timing in boys and girls: A systematic review and meta-analysis
In recent years, the phenomenon of abnormal pubertal timing in children has become increasingly common worldwide. Persistent organic pollutants (POPs) may be one of the risk factors contributing to this phenomenon, but the relationship between them is unclear based on current evidence. The purpose o...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323010448 |
| _version_ | 1797660365569392640 |
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| author | Huili Lan Zhiqin Hu Hongya Gan Lixiang Wu Shushu Xie Yan Jiang Ding Ye Xiaoqing Ye |
| author_facet | Huili Lan Zhiqin Hu Hongya Gan Lixiang Wu Shushu Xie Yan Jiang Ding Ye Xiaoqing Ye |
| author_sort | Huili Lan |
| collection | DOAJ |
| description | In recent years, the phenomenon of abnormal pubertal timing in children has become increasingly common worldwide. Persistent organic pollutants (POPs) may be one of the risk factors contributing to this phenomenon, but the relationship between them is unclear based on current evidence. The purpose of this study was to determine the association of POPs exposure with pubertal timing in girls and boys by conducting a systematic review and meta-analysis. We searched PubMed and Embase databases for studies before June 1, 2023. Meta-analysis was performed by pooling relative risk (RR) or odds ratio (OR) or prevalence ratio (PR) or hazard ratio (HR) estimates with 95 % confidence intervals (CIs). Subgroup analysis, publication bias assessment and sensitivity analysis were also carried out. A total of 21 studies were included, involving 2479 boys and 8718 girls. The results of meta-analysis showed that exposure to POPs was significantly associated with delayed pubertal timing in girls (RR: 0.85; 95 % CI: 0.79–0.91; p < 0.001). There was no statistically significant association between exposure to POPs and pubertal timing in boys (RR: 1.18; 95 % CI: 0.99–1.40; p = 0.070). Subgroup analysis showed that there may be gender differences in the effects of exposure to POPs on pubertal timing. Our results suggested that exposure to POPs could delay pubertal timing in girls. However, based on current evidence, no significant association was found between POPs exposure and pubertal timing in boys. |
| first_indexed | 2024-03-11T18:28:43Z |
| format | Article |
| id | doaj.art-36aeca00832c4b1eb4aa24a8665c3013 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-11T18:28:43Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-36aeca00832c4b1eb4aa24a8665c30132023-10-13T13:52:03ZengElsevierEcotoxicology and Environmental Safety0147-65132023-10-01265115540Association between exposure to persistent organic pollutants and pubertal timing in boys and girls: A systematic review and meta-analysisHuili Lan0Zhiqin Hu1Hongya Gan2Lixiang Wu3Shushu Xie4Yan Jiang5Ding Ye6Xiaoqing Ye7School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, China; Correspondence to: Zhejiang Chinese Medical University, Binjiang District, Hangzhou, Zhejiang Province, China.In recent years, the phenomenon of abnormal pubertal timing in children has become increasingly common worldwide. Persistent organic pollutants (POPs) may be one of the risk factors contributing to this phenomenon, but the relationship between them is unclear based on current evidence. The purpose of this study was to determine the association of POPs exposure with pubertal timing in girls and boys by conducting a systematic review and meta-analysis. We searched PubMed and Embase databases for studies before June 1, 2023. Meta-analysis was performed by pooling relative risk (RR) or odds ratio (OR) or prevalence ratio (PR) or hazard ratio (HR) estimates with 95 % confidence intervals (CIs). Subgroup analysis, publication bias assessment and sensitivity analysis were also carried out. A total of 21 studies were included, involving 2479 boys and 8718 girls. The results of meta-analysis showed that exposure to POPs was significantly associated with delayed pubertal timing in girls (RR: 0.85; 95 % CI: 0.79–0.91; p < 0.001). There was no statistically significant association between exposure to POPs and pubertal timing in boys (RR: 1.18; 95 % CI: 0.99–1.40; p = 0.070). Subgroup analysis showed that there may be gender differences in the effects of exposure to POPs on pubertal timing. Our results suggested that exposure to POPs could delay pubertal timing in girls. However, based on current evidence, no significant association was found between POPs exposure and pubertal timing in boys.http://www.sciencedirect.com/science/article/pii/S0147651323010448Persistent organic pollutantsGirlsBoysPubertal timingMeta-analysis |
| spellingShingle | Huili Lan Zhiqin Hu Hongya Gan Lixiang Wu Shushu Xie Yan Jiang Ding Ye Xiaoqing Ye Association between exposure to persistent organic pollutants and pubertal timing in boys and girls: A systematic review and meta-analysis Ecotoxicology and Environmental Safety Persistent organic pollutants Girls Boys Pubertal timing Meta-analysis |
| title | Association between exposure to persistent organic pollutants and pubertal timing in boys and girls: A systematic review and meta-analysis |
| title_full | Association between exposure to persistent organic pollutants and pubertal timing in boys and girls: A systematic review and meta-analysis |
| title_fullStr | Association between exposure to persistent organic pollutants and pubertal timing in boys and girls: A systematic review and meta-analysis |
| title_full_unstemmed | Association between exposure to persistent organic pollutants and pubertal timing in boys and girls: A systematic review and meta-analysis |
| title_short | Association between exposure to persistent organic pollutants and pubertal timing in boys and girls: A systematic review and meta-analysis |
| title_sort | association between exposure to persistent organic pollutants and pubertal timing in boys and girls a systematic review and meta analysis |
| topic | Persistent organic pollutants Girls Boys Pubertal timing Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323010448 |
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