Uncovering the link between celiac disease and hypopituitarism: a case report and review of literature
Abstract Background Celiac disease, an autoimmune condition triggered by gluten-containing diet, is known to primarily manifest as intestinal symptoms, but can also lead to extraintestinal complications, including endocrine abnormalities and autoimmune disorders. This case report outlines a patient...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-08-01
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| Series: | The Egyptian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43162-023-00246-9 |
| _version_ | 1827633042366136320 |
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| author | Hameed Haidar Khan Imran Ullah Javeria Rufaq Qaiser Wadood Imad Majeed Salman Khan |
| author_facet | Hameed Haidar Khan Imran Ullah Javeria Rufaq Qaiser Wadood Imad Majeed Salman Khan |
| author_sort | Hameed Haidar Khan |
| collection | DOAJ |
| description | Abstract Background Celiac disease, an autoimmune condition triggered by gluten-containing diet, is known to primarily manifest as intestinal symptoms, but can also lead to extraintestinal complications, including endocrine abnormalities and autoimmune disorders. This case report outlines a patient with celiac disease who developed hypopituitarism and explores the possible pathophysiological links between these two conditions. Case presentation We report a case of a 19-year-old female who presented with lethargy, weakness, delayed menarche, and failure to thrive. Subsequent investigations revealed microcytic anemia with decreased serum ferritin and vitamin D levels. Following the identification of abnormal bone age on X-ray, a hormonal profile was requested which revealed panhypopituitarism. After undergoing a diagnostic workup for her gastrointestinal symptoms, she was eventually diagnosed with celiac disease, and her symptoms improved significantly following gluten restriction. Conclusion Panhypopituitarism has a possible association with celiac disease, and this case highlights the importance of close monitoring and appropriate management to prevent long-term health consequences. Additional research is necessary to gain a comprehensive understanding of the link between celiac disease and endocrine disorders. |
| first_indexed | 2024-03-09T14:54:02Z |
| format | Article |
| id | doaj.art-36b16698996a4d0a9eeaa2eb1df48ec6 |
| institution | Directory Open Access Journal |
| issn | 2090-9098 |
| language | English |
| last_indexed | 2024-03-09T14:54:02Z |
| publishDate | 2023-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj.art-36b16698996a4d0a9eeaa2eb1df48ec62023-11-26T14:17:49ZengSpringerOpenThe Egyptian Journal of Internal Medicine2090-90982023-08-013511410.1186/s43162-023-00246-9Uncovering the link between celiac disease and hypopituitarism: a case report and review of literatureHameed Haidar Khan0Imran Ullah1Javeria Rufaq2Qaiser Wadood3Imad Majeed4Salman Khan5Khyber Teaching HospitalKhyber Teaching HospitalSir Ganga Ram HospitalKhyber Teaching HospitalKhyber Teaching HospitalKhyber Teaching HospitalAbstract Background Celiac disease, an autoimmune condition triggered by gluten-containing diet, is known to primarily manifest as intestinal symptoms, but can also lead to extraintestinal complications, including endocrine abnormalities and autoimmune disorders. This case report outlines a patient with celiac disease who developed hypopituitarism and explores the possible pathophysiological links between these two conditions. Case presentation We report a case of a 19-year-old female who presented with lethargy, weakness, delayed menarche, and failure to thrive. Subsequent investigations revealed microcytic anemia with decreased serum ferritin and vitamin D levels. Following the identification of abnormal bone age on X-ray, a hormonal profile was requested which revealed panhypopituitarism. After undergoing a diagnostic workup for her gastrointestinal symptoms, she was eventually diagnosed with celiac disease, and her symptoms improved significantly following gluten restriction. Conclusion Panhypopituitarism has a possible association with celiac disease, and this case highlights the importance of close monitoring and appropriate management to prevent long-term health consequences. Additional research is necessary to gain a comprehensive understanding of the link between celiac disease and endocrine disorders.https://doi.org/10.1186/s43162-023-00246-9Celiac diseaseCoeliac diseasePanhypopituitarismHypopituitarismAutoimmune hypopituitarismHypophysitis |
| spellingShingle | Hameed Haidar Khan Imran Ullah Javeria Rufaq Qaiser Wadood Imad Majeed Salman Khan Uncovering the link between celiac disease and hypopituitarism: a case report and review of literature The Egyptian Journal of Internal Medicine Celiac disease Coeliac disease Panhypopituitarism Hypopituitarism Autoimmune hypopituitarism Hypophysitis |
| title | Uncovering the link between celiac disease and hypopituitarism: a case report and review of literature |
| title_full | Uncovering the link between celiac disease and hypopituitarism: a case report and review of literature |
| title_fullStr | Uncovering the link between celiac disease and hypopituitarism: a case report and review of literature |
| title_full_unstemmed | Uncovering the link between celiac disease and hypopituitarism: a case report and review of literature |
| title_short | Uncovering the link between celiac disease and hypopituitarism: a case report and review of literature |
| title_sort | uncovering the link between celiac disease and hypopituitarism a case report and review of literature |
| topic | Celiac disease Coeliac disease Panhypopituitarism Hypopituitarism Autoimmune hypopituitarism Hypophysitis |
| url | https://doi.org/10.1186/s43162-023-00246-9 |
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