Poor sleep quality association with higher lung cancer risk: a nested case-control study
Background Little is known about the relationship between sleep quality and lung cancer incidence. Thus, this study was conducted to investigate the potential connection between sleep quality and lung cancer incidence. Methods We performed and selected a nested case–control study that included 150 l...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2023-12-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/16540.pdf |
| _version_ | 1797387986304761856 |
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| author | Guo-Tian Ruan Ya-Ping Wei Yi-Zhong Ge Li-Shun Liu Zi-Yi Zhou Sultan Mehmood Siddiqi Qiang-Qiang He Shu-Qun Li Jia-Feng Xu Yun Song Qi Zhang Xi Zhang Ming Yang Ping Chen Yong Sun Xiao-Bin Wang Bin-Yan Wang Han-Ping Shi |
| author_facet | Guo-Tian Ruan Ya-Ping Wei Yi-Zhong Ge Li-Shun Liu Zi-Yi Zhou Sultan Mehmood Siddiqi Qiang-Qiang He Shu-Qun Li Jia-Feng Xu Yun Song Qi Zhang Xi Zhang Ming Yang Ping Chen Yong Sun Xiao-Bin Wang Bin-Yan Wang Han-Ping Shi |
| author_sort | Guo-Tian Ruan |
| collection | DOAJ |
| description | Background Little is known about the relationship between sleep quality and lung cancer incidence. Thus, this study was conducted to investigate the potential connection between sleep quality and lung cancer incidence. Methods We performed and selected a nested case–control study that included 150 lung cancer cases and 150 matched controls based on the Lianyungang cohort. Univariate and multivariate logistic regression was utilized to investigate the connection between potential risk factors and lung cancer incidence risk. Results In this study, the average age of participants was 66.5 ± 9.1 years, with 58.7% being male, and 52.7% reportedly experiencing sleep quality problems. The results of multivariate logistic regression showed that poor sleep quality was connected to an increased lung cancer incidence risk (P = 0.033, odds ratio = 1.83, 95% confidence interval = [1.05–3.19]) compared with those with good sleep quality. The stratified analyses showed a significantly positive connection between poor sleep quality (vs. good sleep quality) and cancer risk in smokers (vs. non-smoker, P for interaction = 0.085). The combined effect analysis indicated that smokers with poor sleep quality suffered from a 2.79-fold increase in cancer incidence rates when compared with non-smokers with good sleep quality. Conclusions Poor sleep quality was positively connected to an increased lung cancer incidence risk. In addition, among those individuals with poor sleep quality, smoking increased the lung cancer incidence risk. |
| first_indexed | 2024-03-08T22:33:11Z |
| format | Article |
| id | doaj.art-36b23fe079284b5c83f4838bb5bece5a |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-08T22:33:11Z |
| publishDate | 2023-12-01 |
| publisher | PeerJ Inc. |
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| series | PeerJ |
| spelling | doaj.art-36b23fe079284b5c83f4838bb5bece5a2023-12-17T15:05:12ZengPeerJ Inc.PeerJ2167-83592023-12-0111e1654010.7717/peerj.16540Poor sleep quality association with higher lung cancer risk: a nested case-control studyGuo-Tian Ruan0Ya-Ping Wei1Yi-Zhong Ge2Li-Shun Liu3Zi-Yi Zhou4Sultan Mehmood Siddiqi5Qiang-Qiang He6Shu-Qun Li7Jia-Feng Xu8Yun Song9Qi Zhang10Xi Zhang11Ming Yang12Ping Chen13Yong Sun14Xiao-Bin Wang15Bin-Yan Wang16Han-Ping Shi17National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, ChinaCollege of Public Health, Shanghai University of Medicine and Health Sciences, Shanghai, ChinaNational Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, ChinaGraduate School at Shenzhen, Tsinghua University, Shenzhen, ChinaGraduate School at Shenzhen, Tsinghua University, Shenzhen, ChinaGraduate School at Shenzhen, Tsinghua University, Shenzhen, ChinaGraduate School at Shenzhen, Tsinghua University, Shenzhen, ChinaShenzhen Evergreen Medical Institute, Shenzhen, ChinaShenzhen Evergreen Medical Institute, Shenzhen, ChinaAUSA Research Institute, Shenzhen AUSA Pharmed Co Ltd, Shenzhen, ChinaNational Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, ChinaNational Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, ChinaNational Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, ChinaInspection and Testing Center, Key Laboratory of Cancer FSMP for State Market Regulation, Shenzhen, ChinaThe First People’s Hospital of Lianyungang City, the First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, ChinaDepartment of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, USAShenzhen Evergreen Medical Institute, Shenzhen, ChinaNational Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, ChinaBackground Little is known about the relationship between sleep quality and lung cancer incidence. Thus, this study was conducted to investigate the potential connection between sleep quality and lung cancer incidence. Methods We performed and selected a nested case–control study that included 150 lung cancer cases and 150 matched controls based on the Lianyungang cohort. Univariate and multivariate logistic regression was utilized to investigate the connection between potential risk factors and lung cancer incidence risk. Results In this study, the average age of participants was 66.5 ± 9.1 years, with 58.7% being male, and 52.7% reportedly experiencing sleep quality problems. The results of multivariate logistic regression showed that poor sleep quality was connected to an increased lung cancer incidence risk (P = 0.033, odds ratio = 1.83, 95% confidence interval = [1.05–3.19]) compared with those with good sleep quality. The stratified analyses showed a significantly positive connection between poor sleep quality (vs. good sleep quality) and cancer risk in smokers (vs. non-smoker, P for interaction = 0.085). The combined effect analysis indicated that smokers with poor sleep quality suffered from a 2.79-fold increase in cancer incidence rates when compared with non-smokers with good sleep quality. Conclusions Poor sleep quality was positively connected to an increased lung cancer incidence risk. In addition, among those individuals with poor sleep quality, smoking increased the lung cancer incidence risk.https://peerj.com/articles/16540.pdfSleep qualityCancer incidenceSmokingNested case–control |
| spellingShingle | Guo-Tian Ruan Ya-Ping Wei Yi-Zhong Ge Li-Shun Liu Zi-Yi Zhou Sultan Mehmood Siddiqi Qiang-Qiang He Shu-Qun Li Jia-Feng Xu Yun Song Qi Zhang Xi Zhang Ming Yang Ping Chen Yong Sun Xiao-Bin Wang Bin-Yan Wang Han-Ping Shi Poor sleep quality association with higher lung cancer risk: a nested case-control study PeerJ Sleep quality Cancer incidence Smoking Nested case–control |
| title | Poor sleep quality association with higher lung cancer risk: a nested case-control study |
| title_full | Poor sleep quality association with higher lung cancer risk: a nested case-control study |
| title_fullStr | Poor sleep quality association with higher lung cancer risk: a nested case-control study |
| title_full_unstemmed | Poor sleep quality association with higher lung cancer risk: a nested case-control study |
| title_short | Poor sleep quality association with higher lung cancer risk: a nested case-control study |
| title_sort | poor sleep quality association with higher lung cancer risk a nested case control study |
| topic | Sleep quality Cancer incidence Smoking Nested case–control |
| url | https://peerj.com/articles/16540.pdf |
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