Durability of Benefits From Supervised Treadmill Exercise in People With Peripheral Artery Disease
Background It is currently unknown whether 6 months of supervised treadmill exercise has a durable benefit on 6‐minute walk performance, even after exercise is completed, in people with peripheral artery disease. Methods and Results A total of 156 participants with peripheral artery disease were ran...
| Váldodahkkit: | , , , , , , , , , , |
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| Materiálatiipa: | Artihkal |
| Giella: | English |
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Wiley
2019-01-01
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| Ráidu: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Fáttát: | |
| Liŋkkat: | https://www.ahajournals.org/doi/10.1161/JAHA.118.009380 |
| _version_ | 1828876118058336256 |
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| author | Mary M. McDermott Melina R. Kibbe Jack M. Guralnik Luigi Ferrucci Michael H. Criqui Kathryn Domanchuk Lu Tian Lihui Zhao Lingyu Li Kruti Patel Tamar S. Polonsky |
| author_facet | Mary M. McDermott Melina R. Kibbe Jack M. Guralnik Luigi Ferrucci Michael H. Criqui Kathryn Domanchuk Lu Tian Lihui Zhao Lingyu Li Kruti Patel Tamar S. Polonsky |
| author_sort | Mary M. McDermott |
| collection | DOAJ |
| description | Background It is currently unknown whether 6 months of supervised treadmill exercise has a durable benefit on 6‐minute walk performance, even after exercise is completed, in people with peripheral artery disease. Methods and Results A total of 156 participants with peripheral artery disease were randomized to 1 of 3 groups: supervised treadmill exercise, supervised resistance training, or attention control. Participants received supervised sessions during months 1 to 6 and telephone contact during months 6 to 12. Primary outcomes were change in 6‐minute walk distance and short physical performance battery at 6‐month follow‐up and have been reported previously. Secondary outcomes were change in 6‐minute walk and short physical performance battery at 12‐month follow‐up and are reported here. A group of 134 participants (86%) completed the 12‐month follow‐up. At 6‐month follow‐up, compared with control, 6‐minute walk distance improved in the treadmill exercise group (+36.1 m, 95% CI=13.9‐58.3, P=0.001). Between 6‐ and 12‐month follow‐up, 6‐minute walk distance significantly declined (−28.6 m, 95% CI=−52.6 to −4.5, P=0.020) and physical activity declined −272 activity units (95% CI=−546 to +2, P=0.052) in the treadmill exercise group compared with controls. At 12‐month follow‐up, 6 months after completing supervised treadmill exercise, change in 6‐minute walk distance was not different between the treadmill exercise and control groups (+7.5, 95% CI=−17.5 to +32.6, P=0.56). There were no differences in short physical performance battery change between either exercise group and control at 6‐month or 12‐month follow‐up. Conclusions A 6‐month supervised treadmill exercise intervention that improved 6‐minute walk distance at 6‐month follow‐up did not have persistent benefit at 12‐month follow‐up. These results do not support a durable benefit of supervised treadmill exercise in peripheral artery disease. Clinical Trial Registration URL: https://www.clinicaltrials.gov. Identifier: NCT00106327. |
| first_indexed | 2024-12-13T08:13:25Z |
| format | Article |
| id | doaj.art-36b5bde947b14d8db49a7e901b41ff14 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T08:13:25Z |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-36b5bde947b14d8db49a7e901b41ff142022-12-21T23:54:09ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802019-01-018110.1161/JAHA.118.009380Durability of Benefits From Supervised Treadmill Exercise in People With Peripheral Artery DiseaseMary M. McDermott0Melina R. Kibbe1Jack M. Guralnik2Luigi Ferrucci3Michael H. Criqui4Kathryn Domanchuk5Lu Tian6Lihui Zhao7Lingyu Li8Kruti Patel9Tamar S. Polonsky10Department of Medicine Northwestern University Feinberg School of Medicine Chicago ILDepartment of Surgery University of North Carolina Chapel Hill NCDepartment of Epidemiology and Public Health University of Maryland School of Medicine Baltimore MDLongitudinal Studies Section of the Translational Gerontology Branch National Institute on Aging Baltimore MDDepartment of Family Medicine and Public Health University of California San Diego La Jolla CADepartment of Medicine Northwestern University Feinberg School of Medicine Chicago ILDepartment of Biomedical Data Science Stanford University Palo Alto CADepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago ILDepartment of Medicine Northwestern University Feinberg School of Medicine Chicago ILUniversity of Illinois College of Medicine at Chicago ILDepartment of Medicine University of Chicago ILBackground It is currently unknown whether 6 months of supervised treadmill exercise has a durable benefit on 6‐minute walk performance, even after exercise is completed, in people with peripheral artery disease. Methods and Results A total of 156 participants with peripheral artery disease were randomized to 1 of 3 groups: supervised treadmill exercise, supervised resistance training, or attention control. Participants received supervised sessions during months 1 to 6 and telephone contact during months 6 to 12. Primary outcomes were change in 6‐minute walk distance and short physical performance battery at 6‐month follow‐up and have been reported previously. Secondary outcomes were change in 6‐minute walk and short physical performance battery at 12‐month follow‐up and are reported here. A group of 134 participants (86%) completed the 12‐month follow‐up. At 6‐month follow‐up, compared with control, 6‐minute walk distance improved in the treadmill exercise group (+36.1 m, 95% CI=13.9‐58.3, P=0.001). Between 6‐ and 12‐month follow‐up, 6‐minute walk distance significantly declined (−28.6 m, 95% CI=−52.6 to −4.5, P=0.020) and physical activity declined −272 activity units (95% CI=−546 to +2, P=0.052) in the treadmill exercise group compared with controls. At 12‐month follow‐up, 6 months after completing supervised treadmill exercise, change in 6‐minute walk distance was not different between the treadmill exercise and control groups (+7.5, 95% CI=−17.5 to +32.6, P=0.56). There were no differences in short physical performance battery change between either exercise group and control at 6‐month or 12‐month follow‐up. Conclusions A 6‐month supervised treadmill exercise intervention that improved 6‐minute walk distance at 6‐month follow‐up did not have persistent benefit at 12‐month follow‐up. These results do not support a durable benefit of supervised treadmill exercise in peripheral artery disease. Clinical Trial Registration URL: https://www.clinicaltrials.gov. Identifier: NCT00106327.https://www.ahajournals.org/doi/10.1161/JAHA.118.009380exerciseexercise trainingfunctional capacity impairmentperipheral artery disease |
| spellingShingle | Mary M. McDermott Melina R. Kibbe Jack M. Guralnik Luigi Ferrucci Michael H. Criqui Kathryn Domanchuk Lu Tian Lihui Zhao Lingyu Li Kruti Patel Tamar S. Polonsky Durability of Benefits From Supervised Treadmill Exercise in People With Peripheral Artery Disease Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease exercise exercise training functional capacity impairment peripheral artery disease |
| title | Durability of Benefits From Supervised Treadmill Exercise in People With Peripheral Artery Disease |
| title_full | Durability of Benefits From Supervised Treadmill Exercise in People With Peripheral Artery Disease |
| title_fullStr | Durability of Benefits From Supervised Treadmill Exercise in People With Peripheral Artery Disease |
| title_full_unstemmed | Durability of Benefits From Supervised Treadmill Exercise in People With Peripheral Artery Disease |
| title_short | Durability of Benefits From Supervised Treadmill Exercise in People With Peripheral Artery Disease |
| title_sort | durability of benefits from supervised treadmill exercise in people with peripheral artery disease |
| topic | exercise exercise training functional capacity impairment peripheral artery disease |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.118.009380 |
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