Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury
Peripheral nerve injury is a common medical condition that has a great impact on patient quality of life. Currently, surgical management is considered to be a gold standard first-line treatment; however, is often not successful and requires further surgical procedures. Commercially available FDA- an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/1/73 |
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| author | Mina Aleemardani Pariya Zare Amelia Seifalian Zohreh Bagher Alexander M. Seifalian |
| author_facet | Mina Aleemardani Pariya Zare Amelia Seifalian Zohreh Bagher Alexander M. Seifalian |
| author_sort | Mina Aleemardani |
| collection | DOAJ |
| description | Peripheral nerve injury is a common medical condition that has a great impact on patient quality of life. Currently, surgical management is considered to be a gold standard first-line treatment; however, is often not successful and requires further surgical procedures. Commercially available FDA- and CE-approved decellularized nerve conduits offer considerable benefits to patients suffering from a completely transected nerve but they fail to support neural regeneration in gaps > 30 mm. To address this unmet clinical need, current research is focused on biomaterial-based therapies to regenerate dysfunctional neural tissues, specifically damaged peripheral nerve, and spinal cord. Recently, attention has been paid to the capability of graphene-based materials (GBMs) to develop bifunctional scaffolds for promoting nerve regeneration, often via supporting enhanced neural differentiation. The unique features of GBMs have been applied to fabricate an electroactive conductive surface in order to direct stem cells and improve neural proliferation and differentiation. The use of GBMs for nerve tissue engineering (NTE) is considered an emerging technology bringing hope to peripheral nerve injury repair, with some products already in preclinical stages. This review assesses the last six years of research in the field of GBMs application in NTE, focusing on the fabrication and effects of GBMs for neurogenesis in various scaffold forms, including electrospun fibres, films, hydrogels, foams, 3D printing, and bioprinting. |
| first_indexed | 2024-03-10T01:51:47Z |
| format | Article |
| id | doaj.art-36b918e2f926431ab2e352a8924d6c96 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T01:51:47Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-36b918e2f926431ab2e352a8924d6c962023-11-23T13:03:20ZengMDPI AGBiomedicines2227-90592021-12-011017310.3390/biomedicines10010073Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve InjuryMina Aleemardani0Pariya Zare1Amelia Seifalian2Zohreh Bagher3Alexander M. Seifalian4Biomaterials and Tissue Engineering Group, Department of Materials Science and Engineering, Kroto Research Institute, The University of Sheffield, Sheffield S3 7HQ, UKDepartment of Chemical Engineering, University of Tehran, Tehran 1417935840, IranDepartment of Surgery and Cancer, Imperial College London, London W12 0NN, UKENT and Head and Neck Research Centre, Hazrat Rasoul Akram Hospital, The Five Senses Health Institute, Iran University of Medical Sciences, Tehran 16844, IranNanotechnology and Regenerative Medicine Commercialization Centre (NanoRegMed Ltd.), London BioScience Innovation Centre, London NW1 0NH, UKPeripheral nerve injury is a common medical condition that has a great impact on patient quality of life. Currently, surgical management is considered to be a gold standard first-line treatment; however, is often not successful and requires further surgical procedures. Commercially available FDA- and CE-approved decellularized nerve conduits offer considerable benefits to patients suffering from a completely transected nerve but they fail to support neural regeneration in gaps > 30 mm. To address this unmet clinical need, current research is focused on biomaterial-based therapies to regenerate dysfunctional neural tissues, specifically damaged peripheral nerve, and spinal cord. Recently, attention has been paid to the capability of graphene-based materials (GBMs) to develop bifunctional scaffolds for promoting nerve regeneration, often via supporting enhanced neural differentiation. The unique features of GBMs have been applied to fabricate an electroactive conductive surface in order to direct stem cells and improve neural proliferation and differentiation. The use of GBMs for nerve tissue engineering (NTE) is considered an emerging technology bringing hope to peripheral nerve injury repair, with some products already in preclinical stages. This review assesses the last six years of research in the field of GBMs application in NTE, focusing on the fabrication and effects of GBMs for neurogenesis in various scaffold forms, including electrospun fibres, films, hydrogels, foams, 3D printing, and bioprinting.https://www.mdpi.com/2227-9059/10/1/73graphene-based materialsnervous systemnerve tissue engineeringnerve proliferationnerve differentiationsurgery |
| spellingShingle | Mina Aleemardani Pariya Zare Amelia Seifalian Zohreh Bagher Alexander M. Seifalian Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury Biomedicines graphene-based materials nervous system nerve tissue engineering nerve proliferation nerve differentiation surgery |
| title | Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury |
| title_full | Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury |
| title_fullStr | Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury |
| title_full_unstemmed | Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury |
| title_short | Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury |
| title_sort | graphene based materials prove to be a promising candidate for nerve regeneration following peripheral nerve injury |
| topic | graphene-based materials nervous system nerve tissue engineering nerve proliferation nerve differentiation surgery |
| url | https://www.mdpi.com/2227-9059/10/1/73 |
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