Cerium oxide nanoparticle modulates hepatic damage, inflammatory and oxidative stress biomarkers in a dose-dependent manner: an in vivo study of rat liver
Objective (s): Cerium oxide nanoparticles nanoceria (CeNPs) is a novel nanoparticle that has great potential for the treatment of various diseases. This study aimed to investigate the effects of CeNPs on oxidative stress biomarkers in the liver of male rats. Materials and Methods: Twenty-four male W...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2018-10-01
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| Series: | Nanomedicine Journal |
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| Online Access: | http://nmj.mums.ac.ir/article_11607_572be6f2138220487a3fe42387ebf2e8.pdf |
| _version_ | 1817981514637377536 |
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| author | Akram Ranjbar Hassan Ghasemi Ali Abedian Nejat Kheiripour |
| author_facet | Akram Ranjbar Hassan Ghasemi Ali Abedian Nejat Kheiripour |
| author_sort | Akram Ranjbar |
| collection | DOAJ |
| description | Objective (s): Cerium oxide nanoparticles nanoceria (CeNPs) is a novel nanoparticle that has great potential for the treatment of various diseases. This study aimed to investigate the effects of CeNPs on oxidative stress biomarkers in the liver of male rats. Materials and Methods: Twenty-four male Wistar rats were equally distributed into 4 groups (n=6/each). The first group was controlled and the next three groups received CeNPs (15, 30 and 60 mg/kg/day), with an intraperitoneal injection (IP) for 7 days. After treatment, serum and liver tissue was isolated. ALT and AST concentration, total antioxidant capacity (TAC), total thiol molecules (TTM), interleukin 17 (IL-17), nitric oxide (NO) and TNF-α were measured. Results: CeNPs 30, 60 mg/kg caused a significant increased NO (P=0.03, P=0.001), TNF-α (P=0.03, P=0.01) and IL-17 (P=0.04, P=0.01) levels, compared with the control group. Also CeNPs caused a decrease in the TTM (P=0.002) and increased MDA (P=0.04) in 60 mg/kg group compared to the control group. CeNPs 15 mg/kg significantly suppressed mainly the increase in plasma activities of aminotransferases (ALT (P=0.001), AST (P=0.01)), and liver IL-17 (P=0.01) and NO (P=0.02) concentrations compared to the control group. Conclusion: These results suggest that the effects of CeNPs are dose-dependent and at 15 mg/kg dose, it may have protective effects. Moreover, CeNPs in 30 and 60mg/kg doses showed immunotoxicity and oxidative effects in the liver. |
| first_indexed | 2024-04-13T23:07:10Z |
| format | Article |
| id | doaj.art-36b9698aec444606b58d72edba26b268 |
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| issn | 2322-3049 2322-5904 |
| language | English |
| last_indexed | 2024-04-13T23:07:10Z |
| publishDate | 2018-10-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Nanomedicine Journal |
| spelling | doaj.art-36b9698aec444606b58d72edba26b2682022-12-22T02:25:39ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042018-10-015424525010.22038/nmj.2018.05.0000911607Cerium oxide nanoparticle modulates hepatic damage, inflammatory and oxidative stress biomarkers in a dose-dependent manner: an in vivo study of rat liverAkram Ranjbar0Hassan Ghasemi1Ali Abedian2Nejat Kheiripour3Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranAbadan School of Medical Sciences, Abadan, IranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical ciences, Kashan, IranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical ciences, Kashan, IranObjective (s): Cerium oxide nanoparticles nanoceria (CeNPs) is a novel nanoparticle that has great potential for the treatment of various diseases. This study aimed to investigate the effects of CeNPs on oxidative stress biomarkers in the liver of male rats. Materials and Methods: Twenty-four male Wistar rats were equally distributed into 4 groups (n=6/each). The first group was controlled and the next three groups received CeNPs (15, 30 and 60 mg/kg/day), with an intraperitoneal injection (IP) for 7 days. After treatment, serum and liver tissue was isolated. ALT and AST concentration, total antioxidant capacity (TAC), total thiol molecules (TTM), interleukin 17 (IL-17), nitric oxide (NO) and TNF-α were measured. Results: CeNPs 30, 60 mg/kg caused a significant increased NO (P=0.03, P=0.001), TNF-α (P=0.03, P=0.01) and IL-17 (P=0.04, P=0.01) levels, compared with the control group. Also CeNPs caused a decrease in the TTM (P=0.002) and increased MDA (P=0.04) in 60 mg/kg group compared to the control group. CeNPs 15 mg/kg significantly suppressed mainly the increase in plasma activities of aminotransferases (ALT (P=0.001), AST (P=0.01)), and liver IL-17 (P=0.01) and NO (P=0.02) concentrations compared to the control group. Conclusion: These results suggest that the effects of CeNPs are dose-dependent and at 15 mg/kg dose, it may have protective effects. Moreover, CeNPs in 30 and 60mg/kg doses showed immunotoxicity and oxidative effects in the liver.http://nmj.mums.ac.ir/article_11607_572be6f2138220487a3fe42387ebf2e8.pdfCerium oxide nanoparticlesLiverOxidative stress |
| spellingShingle | Akram Ranjbar Hassan Ghasemi Ali Abedian Nejat Kheiripour Cerium oxide nanoparticle modulates hepatic damage, inflammatory and oxidative stress biomarkers in a dose-dependent manner: an in vivo study of rat liver Nanomedicine Journal Cerium oxide nanoparticles Liver Oxidative stress |
| title | Cerium oxide nanoparticle modulates hepatic damage, inflammatory and oxidative stress biomarkers in a dose-dependent manner: an in vivo study of rat liver |
| title_full | Cerium oxide nanoparticle modulates hepatic damage, inflammatory and oxidative stress biomarkers in a dose-dependent manner: an in vivo study of rat liver |
| title_fullStr | Cerium oxide nanoparticle modulates hepatic damage, inflammatory and oxidative stress biomarkers in a dose-dependent manner: an in vivo study of rat liver |
| title_full_unstemmed | Cerium oxide nanoparticle modulates hepatic damage, inflammatory and oxidative stress biomarkers in a dose-dependent manner: an in vivo study of rat liver |
| title_short | Cerium oxide nanoparticle modulates hepatic damage, inflammatory and oxidative stress biomarkers in a dose-dependent manner: an in vivo study of rat liver |
| title_sort | cerium oxide nanoparticle modulates hepatic damage inflammatory and oxidative stress biomarkers in a dose dependent manner an in vivo study of rat liver |
| topic | Cerium oxide nanoparticles Liver Oxidative stress |
| url | http://nmj.mums.ac.ir/article_11607_572be6f2138220487a3fe42387ebf2e8.pdf |
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