Dimethyl Fumarate Promotes the Survival of Retinal Ganglion Cells after Optic Nerve Injury, Possibly through the Nrf2/HO-1 Pathway

Dimethyl Fumarate Promotes the Survival of Retinal Ganglion Cells after Optic Nerve Injury, Possibly through the Nrf2/HO-1 Pathway

This study aimed to verify whether dimethyl fumarate (DMF) promotes the survival of retinal ganglion cells (RGCs) after optic nerve crush (ONC) accompanied by activation of the NF-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. We examined changes in the densities of tubulin β3 (TUBB3)-p...

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Bibliographic Details
Main Authors: Sotaro Mori, Takuji Kurimoto, Hidetaka Maeda, Makoto Nakamura
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
dimethyl fumarate
neuroprotection
optic nerve crush
retinal ganglion cells
NF-E2-related factor 2
heme oxygenase-1
Online Access:https://www.mdpi.com/1422-0067/22/1/297

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