Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge.

Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge.

We investigated the protective efficacy of two intranasal chitosan (CSN and TM-CSN) adjuvanted H5N1 Influenza vaccines against highly pathogenic avian Influenza (HPAI) intratracheal and intranasal challenge in a ferret model. Six groups of 6 ferrets were intranasally vaccinated twice, 21 days apart,...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Alex J Mann, Nicolas Noulin, Andrew Catchpole, Koert J Stittelaar, Leon de Waal, Edwin J B Veldhuis Kroeze, Michael Hinchcliffe, Alan Smith, Emanuele Montomoli, Simona Piccirella, Albert D M E Osterhaus, Alastair Knight, John S Oxford, Giulia Lapini, Rebecca Cox, Rob Lambkin-Williams
Format: Artykuł
Język:English
Wydane: Public Library of Science (PLoS) 2014-01-01
Seria:PLoS ONE
Dostęp online:http://europepmc.org/articles/PMC4029577?pdf=render

Internet

http://europepmc.org/articles/PMC4029577?pdf=render

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