The clinical impact of serrated colorectal polyps
Brendon M O’Connell,1 Seth D Crockett2 1Department of Medicine, 2Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC, USA Abstract: Serrated polyps (SPs) of the colorectum pose a novel challenge to practicing gastroenterologists. Pr...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2017-02-01
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| Series: | Clinical Epidemiology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-clinical-impact-of-serrated-colorectal-polyps-peer-reviewed-article-CLEP |
| _version_ | 1818064556574900224 |
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| author | O'Connell BM Crockett SD |
| author_facet | O'Connell BM Crockett SD |
| author_sort | O'Connell BM |
| collection | DOAJ |
| description | Brendon M O’Connell,1 Seth D Crockett2 1Department of Medicine, 2Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC, USA Abstract: Serrated polyps (SPs) of the colorectum pose a novel challenge to practicing gastroenterologists. Previously thought benign and unimportant, there is now compelling evidence that SPs are responsible for a significant percentage of incident colorectal cancer worldwide. In contrast to conventional adenomas, which tend to be slow growing and polypoid, SPs have unique features that undermine current screening and surveillance practices. For example, sessile serrated polyps (SSPs) are flat, predominately right-sided, and thought to have the potential for rapid growth. Moreover, SSPs are subject to wide variations in endoscopic detection and pathologic interpretation. Unfortunately, little is known about the natural history of SPs, and current guidelines are based largely on expert opinion. In this review, we outline the current taxonomy, epidemiology, and management of SPs with an emphasis on the clinical and public health impact of these lesions. Keywords: serrated polyp, sessile serrated adenoma, sessile serrated polyp, traditional serrated adenoma, hyperplastic polyp, epidemiology, colonoscopy |
| first_indexed | 2024-12-10T14:37:53Z |
| format | Article |
| id | doaj.art-36bd6aad0faf4d599540053f30483897 |
| institution | Directory Open Access Journal |
| issn | 1179-1349 |
| language | English |
| last_indexed | 2024-12-10T14:37:53Z |
| publishDate | 2017-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Epidemiology |
| spelling | doaj.art-36bd6aad0faf4d599540053f304838972022-12-22T01:44:47ZengDove Medical PressClinical Epidemiology1179-13492017-02-01Volume 911312531475The clinical impact of serrated colorectal polypsO'Connell BMCrockett SDBrendon M O’Connell,1 Seth D Crockett2 1Department of Medicine, 2Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC, USA Abstract: Serrated polyps (SPs) of the colorectum pose a novel challenge to practicing gastroenterologists. Previously thought benign and unimportant, there is now compelling evidence that SPs are responsible for a significant percentage of incident colorectal cancer worldwide. In contrast to conventional adenomas, which tend to be slow growing and polypoid, SPs have unique features that undermine current screening and surveillance practices. For example, sessile serrated polyps (SSPs) are flat, predominately right-sided, and thought to have the potential for rapid growth. Moreover, SSPs are subject to wide variations in endoscopic detection and pathologic interpretation. Unfortunately, little is known about the natural history of SPs, and current guidelines are based largely on expert opinion. In this review, we outline the current taxonomy, epidemiology, and management of SPs with an emphasis on the clinical and public health impact of these lesions. Keywords: serrated polyp, sessile serrated adenoma, sessile serrated polyp, traditional serrated adenoma, hyperplastic polyp, epidemiology, colonoscopyhttps://www.dovepress.com/the-clinical-impact-of-serrated-colorectal-polyps-peer-reviewed-article-CLEPSerrated polypSessile serrated adenomaSessile serrated polypTraditional serrated adenomaHyperplastic polypEpidemiologyColonoscopy |
| spellingShingle | O'Connell BM Crockett SD The clinical impact of serrated colorectal polyps Clinical Epidemiology Serrated polyp Sessile serrated adenoma Sessile serrated polyp Traditional serrated adenoma Hyperplastic polyp Epidemiology Colonoscopy |
| title | The clinical impact of serrated colorectal polyps |
| title_full | The clinical impact of serrated colorectal polyps |
| title_fullStr | The clinical impact of serrated colorectal polyps |
| title_full_unstemmed | The clinical impact of serrated colorectal polyps |
| title_short | The clinical impact of serrated colorectal polyps |
| title_sort | clinical impact of serrated colorectal polyps |
| topic | Serrated polyp Sessile serrated adenoma Sessile serrated polyp Traditional serrated adenoma Hyperplastic polyp Epidemiology Colonoscopy |
| url | https://www.dovepress.com/the-clinical-impact-of-serrated-colorectal-polyps-peer-reviewed-article-CLEP |
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