Reversible Redox Activity by Ion-pH Dually Modulated Duplex Formation of i-Motif DNA with Complementary G-DNA
The unique biological features of supramolecular DNA have led to an increasing interest in biomedical applications such as biosensors. We have developed an i-motif and G-rich DNA conjugated single-walled carbon nanotube hybrid materials, which shows reversible conformational switching upon external...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-04-01
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| Series: | Nanomaterials |
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| Online Access: | http://www.mdpi.com/2079-4991/8/4/226 |
| _version_ | 1818897545905045504 |
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| author | Soyoung Chang Tugba Kilic Chang Kee Lee Huseyin Avci Hojae Bae Shirin Mesbah Oskui Sung Mi Jung Su Ryon Shin Seon Jeong Kim |
| author_facet | Soyoung Chang Tugba Kilic Chang Kee Lee Huseyin Avci Hojae Bae Shirin Mesbah Oskui Sung Mi Jung Su Ryon Shin Seon Jeong Kim |
| author_sort | Soyoung Chang |
| collection | DOAJ |
| description | The unique biological features of supramolecular DNA have led to an increasing interest in biomedical applications such as biosensors. We have developed an i-motif and G-rich DNA conjugated single-walled carbon nanotube hybrid materials, which shows reversible conformational switching upon external stimuli such as pH (5 and 8) and presence of ions (Li+ and K+). We observed reversible electrochemical redox activity upon external stimuli in a quick and robust manner. Given the ease and the robustness of this method, we believe that pH- and ion-driven reversible DNA structure transformations will be utilized for future applications for developing novel biosensors. |
| first_indexed | 2024-12-19T19:17:53Z |
| format | Article |
| id | doaj.art-36bdd9212d0743cca582f37200045ec0 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-19T19:17:53Z |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-36bdd9212d0743cca582f37200045ec02022-12-21T20:09:05ZengMDPI AGNanomaterials2079-49912018-04-018422610.3390/nano8040226nano8040226Reversible Redox Activity by Ion-pH Dually Modulated Duplex Formation of i-Motif DNA with Complementary G-DNASoyoung Chang0Tugba Kilic1Chang Kee Lee2Huseyin Avci3Hojae Bae4Shirin Mesbah Oskui5Sung Mi Jung6Su Ryon Shin7Seon Jeong Kim8Center for Bio-Artificial Muscle and Department of Biomedical Engineering, Hanyang University, Seoul 04763, KoreaDivision of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USAKorea Packaging Center, Korea Institute of Industrial Technology, Bucheon 14449, KoreaDivision of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USAKU Convergence Science and Technology Institute, Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, KoreaDivision of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USAFuture Environmental Research Center, Korea Institute of Toxicology, Jinju 52834, KoreaCenter for Bio-Artificial Muscle and Department of Biomedical Engineering, Hanyang University, Seoul 04763, KoreaCenter for Bio-Artificial Muscle and Department of Biomedical Engineering, Hanyang University, Seoul 04763, KoreaThe unique biological features of supramolecular DNA have led to an increasing interest in biomedical applications such as biosensors. We have developed an i-motif and G-rich DNA conjugated single-walled carbon nanotube hybrid materials, which shows reversible conformational switching upon external stimuli such as pH (5 and 8) and presence of ions (Li+ and K+). We observed reversible electrochemical redox activity upon external stimuli in a quick and robust manner. Given the ease and the robustness of this method, we believe that pH- and ion-driven reversible DNA structure transformations will be utilized for future applications for developing novel biosensors.http://www.mdpi.com/2079-4991/8/4/226carbon nanotubeDNAbiosensor |
| spellingShingle | Soyoung Chang Tugba Kilic Chang Kee Lee Huseyin Avci Hojae Bae Shirin Mesbah Oskui Sung Mi Jung Su Ryon Shin Seon Jeong Kim Reversible Redox Activity by Ion-pH Dually Modulated Duplex Formation of i-Motif DNA with Complementary G-DNA Nanomaterials carbon nanotube DNA biosensor |
| title | Reversible Redox Activity by Ion-pH Dually Modulated Duplex Formation of i-Motif DNA with Complementary G-DNA |
| title_full | Reversible Redox Activity by Ion-pH Dually Modulated Duplex Formation of i-Motif DNA with Complementary G-DNA |
| title_fullStr | Reversible Redox Activity by Ion-pH Dually Modulated Duplex Formation of i-Motif DNA with Complementary G-DNA |
| title_full_unstemmed | Reversible Redox Activity by Ion-pH Dually Modulated Duplex Formation of i-Motif DNA with Complementary G-DNA |
| title_short | Reversible Redox Activity by Ion-pH Dually Modulated Duplex Formation of i-Motif DNA with Complementary G-DNA |
| title_sort | reversible redox activity by ion ph dually modulated duplex formation of i motif dna with complementary g dna |
| topic | carbon nanotube DNA biosensor |
| url | http://www.mdpi.com/2079-4991/8/4/226 |
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