Obesity control and liver health in breast cancer: Normalized hepatic elasticity after ketogenic diet
Most socially significant diseases, including breast cancer, are undeniably linked to obesity. Recently, a positive relationship between excessive weight and increased risk of breast cancer poor outcomes has been proved. Liver integrity is an essential point during chemotherapy. Consequently, a hepa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023076570 |
| _version_ | 1797646503801520128 |
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| author | Aleksandar Georgiev Lyubomir Chervenkov Daniela Koleva Vanya Anastasova |
| author_facet | Aleksandar Georgiev Lyubomir Chervenkov Daniela Koleva Vanya Anastasova |
| author_sort | Aleksandar Georgiev |
| collection | DOAJ |
| description | Most socially significant diseases, including breast cancer, are undeniably linked to obesity. Recently, a positive relationship between excessive weight and increased risk of breast cancer poor outcomes has been proved. Liver integrity is an essential point during chemotherapy. Consequently, a hepatic safe therapeutic approach for managing obesity in patients with breast cancer should be initiated. Our study aimed to assess the impact of the ketogenic diet on body mass index (BMI) and to evaluate its safety on liver function in female patients with breast cancer. The study comprised 520 women with ductal breast cancer who underwent a 60-day modified ketogenic diet. BMI, prothrombin time (PT), activated partial thromboplastin clotting time (aPTT), aspartate aminotransferase to platelet ratio index (APRI), and ultrasound liver elasticity was evaluated before and after the diet. The results showed a significant decrease in BMI and an improvement in ultrasound liver elasticity in all the participants after completing the diet. Before the KD, the participants' median BMI was 35.0 kg/m2, and after the 60-day diet, the median BMI was reduced to 30.0 kg/m2. No significant liver parameter changes were found after the diet. In conclusion, we can safely promote the keto diet amongst individuals with an increased chance of developing breast cancer for a better disease prevention. |
| first_indexed | 2024-03-11T15:03:32Z |
| format | Article |
| id | doaj.art-36bdff2c177348a382931b159e31b27f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T15:03:32Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-36bdff2c177348a382931b159e31b27f2023-10-30T06:06:08ZengElsevierHeliyon2405-84402023-10-01910e20449Obesity control and liver health in breast cancer: Normalized hepatic elasticity after ketogenic dietAleksandar Georgiev0Lyubomir Chervenkov1Daniela Koleva2Vanya Anastasova3Medical University of Plovdiv, Department of Diagnostic Imaging; 15A Vasil Aprilov Blvd., Plovdiv, 4002, Bulgaria; Complex Oncology Center of Plovdiv, 62 Pere Toshev Str., Plovdiv, 4004, Bulgaria; Corresponding author. Medical University of Plovdiv, Department of Diagnostic Imaging; 15A Vasil Aprilov Blvd., Plovdiv, 4002, Bulgaria.Medical University of Plovdiv, Department of Diagnostic Imaging; 15A Vasil Aprilov Blvd., Plovdiv, 4002, BulgariaMedical University of Plovdiv, Department of Endocrinology; 15A Vasil Aprilov Blvd., Plovdiv, 4002, BulgariaMedical University of Plovdiv, Department of Plastic Surgery, 15A Vasil Aprilov Blvd., Plovdiv, 4002, BulgariaMost socially significant diseases, including breast cancer, are undeniably linked to obesity. Recently, a positive relationship between excessive weight and increased risk of breast cancer poor outcomes has been proved. Liver integrity is an essential point during chemotherapy. Consequently, a hepatic safe therapeutic approach for managing obesity in patients with breast cancer should be initiated. Our study aimed to assess the impact of the ketogenic diet on body mass index (BMI) and to evaluate its safety on liver function in female patients with breast cancer. The study comprised 520 women with ductal breast cancer who underwent a 60-day modified ketogenic diet. BMI, prothrombin time (PT), activated partial thromboplastin clotting time (aPTT), aspartate aminotransferase to platelet ratio index (APRI), and ultrasound liver elasticity was evaluated before and after the diet. The results showed a significant decrease in BMI and an improvement in ultrasound liver elasticity in all the participants after completing the diet. Before the KD, the participants' median BMI was 35.0 kg/m2, and after the 60-day diet, the median BMI was reduced to 30.0 kg/m2. No significant liver parameter changes were found after the diet. In conclusion, we can safely promote the keto diet amongst individuals with an increased chance of developing breast cancer for a better disease prevention.http://www.sciencedirect.com/science/article/pii/S2405844023076570Breast cancerKetogenic dietKetonesWeight reductionliver safety |
| spellingShingle | Aleksandar Georgiev Lyubomir Chervenkov Daniela Koleva Vanya Anastasova Obesity control and liver health in breast cancer: Normalized hepatic elasticity after ketogenic diet Heliyon Breast cancer Ketogenic diet Ketones Weight reduction liver safety |
| title | Obesity control and liver health in breast cancer: Normalized hepatic elasticity after ketogenic diet |
| title_full | Obesity control and liver health in breast cancer: Normalized hepatic elasticity after ketogenic diet |
| title_fullStr | Obesity control and liver health in breast cancer: Normalized hepatic elasticity after ketogenic diet |
| title_full_unstemmed | Obesity control and liver health in breast cancer: Normalized hepatic elasticity after ketogenic diet |
| title_short | Obesity control and liver health in breast cancer: Normalized hepatic elasticity after ketogenic diet |
| title_sort | obesity control and liver health in breast cancer normalized hepatic elasticity after ketogenic diet |
| topic | Breast cancer Ketogenic diet Ketones Weight reduction liver safety |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023076570 |
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