Inactivation in the potassium channel KcsA
Inactivation, the slow cessation of transmission after activation, is a general feature of potassium channels. It is essential for their function, and malfunctions in inactivation leads to numerous pathologies. The detailed mechanism for the C-type inactivation, distinct from the N-type inactivation...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-07-01
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| Series: | Journal of Structural Biology: X |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590152419300078 |
| _version_ | 1828398309950095360 |
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| author | Yunyao Xu Ann E. McDermott |
| author_facet | Yunyao Xu Ann E. McDermott |
| author_sort | Yunyao Xu |
| collection | DOAJ |
| description | Inactivation, the slow cessation of transmission after activation, is a general feature of potassium channels. It is essential for their function, and malfunctions in inactivation leads to numerous pathologies. The detailed mechanism for the C-type inactivation, distinct from the N-type inactivation, remains an active area of investigation. Crystallography, computational simulations, and NMR have greatly enriched our understanding of the process. Here we review the major hypotheses regarding C-type inactivation, particularly focusing on the key role played by NMR studies of the prokaryotic potassium channel KcsA, which serves as a good model for voltage gated mammalian channels. Keywords: Potassium channel, C-type inactivation, Solid state NMR, Allosteric coupling, KcsA |
| first_indexed | 2024-12-10T08:59:22Z |
| format | Article |
| id | doaj.art-36becc58404b4e4b97f5d17c81db923c |
| institution | Directory Open Access Journal |
| issn | 2590-1524 |
| language | English |
| last_indexed | 2024-12-10T08:59:22Z |
| publishDate | 2019-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Structural Biology: X |
| spelling | doaj.art-36becc58404b4e4b97f5d17c81db923c2022-12-22T01:55:19ZengElsevierJournal of Structural Biology: X2590-15242019-07-013Inactivation in the potassium channel KcsAYunyao Xu0Ann E. McDermott1Department of Chemistry, Columbia University, New York, NY 10027, United StatesCorresponding author.; Department of Chemistry, Columbia University, New York, NY 10027, United StatesInactivation, the slow cessation of transmission after activation, is a general feature of potassium channels. It is essential for their function, and malfunctions in inactivation leads to numerous pathologies. The detailed mechanism for the C-type inactivation, distinct from the N-type inactivation, remains an active area of investigation. Crystallography, computational simulations, and NMR have greatly enriched our understanding of the process. Here we review the major hypotheses regarding C-type inactivation, particularly focusing on the key role played by NMR studies of the prokaryotic potassium channel KcsA, which serves as a good model for voltage gated mammalian channels. Keywords: Potassium channel, C-type inactivation, Solid state NMR, Allosteric coupling, KcsAhttp://www.sciencedirect.com/science/article/pii/S2590152419300078 |
| spellingShingle | Yunyao Xu Ann E. McDermott Inactivation in the potassium channel KcsA Journal of Structural Biology: X |
| title | Inactivation in the potassium channel KcsA |
| title_full | Inactivation in the potassium channel KcsA |
| title_fullStr | Inactivation in the potassium channel KcsA |
| title_full_unstemmed | Inactivation in the potassium channel KcsA |
| title_short | Inactivation in the potassium channel KcsA |
| title_sort | inactivation in the potassium channel kcsa |
| url | http://www.sciencedirect.com/science/article/pii/S2590152419300078 |
| work_keys_str_mv | AT yunyaoxu inactivationinthepotassiumchannelkcsa AT annemcdermott inactivationinthepotassiumchannelkcsa |