Laxative Effect of Spicatoside A by Cholinergic Regulation of Enteric Nerve in Loperamide-Induced Constipation: ICR Mice Model

Laxative Effect of Spicatoside A by Cholinergic Regulation of Enteric Nerve in Loperamide-Induced Constipation: ICR Mice Model

Researches on spicatoside A (SpiA)-containing natural products suggest the possibility of SpiA as a potential laxative to alleviate chronic constipation. However, no studies have been conducted with single compound administration of SpiA. To verify the laxative effects and mechanism of action of Spi...

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Bibliographic Details
Main Authors: Ji Eun Kim, Ji Won Park, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae, Yusang Choi, Young Ju Lee, Sungbaek Seo, Jin Tae Hong, Dae Youn Hwang
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
spicatoside A
constipation
aquaporin
mucin
muscarinic acetylcholine receptors
gastrin
C-kit
Online Access:http://www.mdpi.com/1420-3049/24/5/896

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