Identification of RSV Fusion Protein Interaction Domains on the Virus Receptor, Nucleolin

Identification of RSV Fusion Protein Interaction Domains on the Virus Receptor, Nucleolin

Nucleolin is an essential cellular receptor to human respiratory syncytial virus (RSV). Pharmacological targeting of the nucleolin RNA binding domain RBD1,2 can inhibit RSV infections in vitro and in vivo; however, the site(s) on RBD1,2 which interact with RSV are not known. We undertook a series of...

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Bibliographic Details
Main Authors: Peter Mastrangelo, Allysia A. Chin, Stephanie Tan, Amy H. Jeon, Cameron A. Ackerley, Karen K. Siu, Jeffrey E. Lee, Richard G. Hegele
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Viruses
Subjects:
RSV
nucleolin
fusion protein
protein–protein interactions
Online Access:https://www.mdpi.com/1999-4915/13/2/261

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