Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome
Introduction: Pregnant women represent a typical group susceptible to dietary and mineral deficiencies. This study was sought to assess the efficacy and safety of various doses of 25-hydroxyvitamin D (25[OH]D) supplementation during pregnancy and ratify the inadequacy of the recommended daily allowa...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=3;spage=337;epage=342;aulast=Mir |
| _version_ | 1818254444658163712 |
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| author | Shahnaz Ahmad Mir Shariq Rashid Masoodi Shafia Shafi Iqra Hameed Maqsood Ahmad Dar Mir Iftikhar Bashir Arshad Iqbal Wani Zaffar Amin Shah Shameema Parveen Abdul Hamid Zargar Parviz Ahmad Shah |
| author_facet | Shahnaz Ahmad Mir Shariq Rashid Masoodi Shafia Shafi Iqra Hameed Maqsood Ahmad Dar Mir Iftikhar Bashir Arshad Iqbal Wani Zaffar Amin Shah Shameema Parveen Abdul Hamid Zargar Parviz Ahmad Shah |
| author_sort | Shahnaz Ahmad Mir |
| collection | DOAJ |
| description | Introduction: Pregnant women represent a typical group susceptible to dietary and mineral deficiencies. This study was sought to assess the efficacy and safety of various doses of 25-hydroxyvitamin D (25[OH]D) supplementation during pregnancy and ratify the inadequacy of the recommended daily allowance for Vitamin D in vulnerable groups. Materials and Methods: A total of 100 pregnant women were included in this open-label, parallel group, prospective, randomized, and controlled trial. Study subjects were assigned to four treatment groups: Group 1 (n = 26), 1000 IU of Vitamin D daily; Group 2 (n = 21), 30,000 IU of Vitamin D monthly; Group 3 (n = 27), 2000 IU of Vitamin D daily; and Group 4 (n = 26), 60,000 IU Vitamin D monthly. Group 1 and 2 were further analyzed together as Group 1K (1000 IU daily and 30,000 IU monthly), and Group 3 and 4 as Group 2K (2000 IU daily and 60,000 IU monthly). The analysis was done on an intention to treat basis. Results: A total of 87 patients completed the study; 21 in Group 1, 25 in Group 2, 18 in Group 3, and 23 in Group 4. The levels of 25(OH)D at baseline ranged from 1.3 to 58.0 with a mean of 24.2 ± 15.1 ng/ml. Postsupplementation, 25(OH)D levels ranged from 11.5 to 70.3 with a mean of 40.2 ± 12.2 ng/ml. The postsupplementation levels of 25(OH)D were higher in Group 2K (42.86 ± 12.83) than in Group 1K (36.96 ± 10.56) with P value of 0.023. Conclusion: We concluded that Vitamin D supplementation with 2000 IU/day or 60,000 IU/month is very effective and safe in achieving Vitamin D sufficiency in pregnant women. |
| first_indexed | 2024-12-12T16:56:04Z |
| format | Article |
| id | doaj.art-36c4db7255484f00b7d19eb49eee6766 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-12-12T16:56:04Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-36c4db7255484f00b7d19eb49eee67662022-12-22T00:18:14ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002016-01-0120333734210.4103/2230-8210.179991Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcomeShahnaz Ahmad MirShariq Rashid MasoodiShafia ShafiIqra HameedMaqsood Ahmad DarMir Iftikhar BashirArshad Iqbal WaniZaffar Amin ShahShameema ParveenAbdul Hamid ZargarParviz Ahmad ShahIntroduction: Pregnant women represent a typical group susceptible to dietary and mineral deficiencies. This study was sought to assess the efficacy and safety of various doses of 25-hydroxyvitamin D (25[OH]D) supplementation during pregnancy and ratify the inadequacy of the recommended daily allowance for Vitamin D in vulnerable groups. Materials and Methods: A total of 100 pregnant women were included in this open-label, parallel group, prospective, randomized, and controlled trial. Study subjects were assigned to four treatment groups: Group 1 (n = 26), 1000 IU of Vitamin D daily; Group 2 (n = 21), 30,000 IU of Vitamin D monthly; Group 3 (n = 27), 2000 IU of Vitamin D daily; and Group 4 (n = 26), 60,000 IU Vitamin D monthly. Group 1 and 2 were further analyzed together as Group 1K (1000 IU daily and 30,000 IU monthly), and Group 3 and 4 as Group 2K (2000 IU daily and 60,000 IU monthly). The analysis was done on an intention to treat basis. Results: A total of 87 patients completed the study; 21 in Group 1, 25 in Group 2, 18 in Group 3, and 23 in Group 4. The levels of 25(OH)D at baseline ranged from 1.3 to 58.0 with a mean of 24.2 ± 15.1 ng/ml. Postsupplementation, 25(OH)D levels ranged from 11.5 to 70.3 with a mean of 40.2 ± 12.2 ng/ml. The postsupplementation levels of 25(OH)D were higher in Group 2K (42.86 ± 12.83) than in Group 1K (36.96 ± 10.56) with P value of 0.023. Conclusion: We concluded that Vitamin D supplementation with 2000 IU/day or 60,000 IU/month is very effective and safe in achieving Vitamin D sufficiency in pregnant women.http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=3;spage=337;epage=342;aulast=MirDoseefficacypregnancyVitamin D |
| spellingShingle | Shahnaz Ahmad Mir Shariq Rashid Masoodi Shafia Shafi Iqra Hameed Maqsood Ahmad Dar Mir Iftikhar Bashir Arshad Iqbal Wani Zaffar Amin Shah Shameema Parveen Abdul Hamid Zargar Parviz Ahmad Shah Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome Indian Journal of Endocrinology and Metabolism Dose efficacy pregnancy Vitamin D |
| title | Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome |
| title_full | Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome |
| title_fullStr | Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome |
| title_full_unstemmed | Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome |
| title_short | Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome |
| title_sort | efficacy and safety of vitamin d supplementation during pregnancy a randomized trial of two different levels of dosing on maternal and neonatal vitamin d outcome |
| topic | Dose efficacy pregnancy Vitamin D |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=3;spage=337;epage=342;aulast=Mir |
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