Deferoxamine Treatment Combined With Sevoflurane Postconditioning Attenuates Myocardial Ischemia-Reperfusion Injury by Restoring HIF-1/BNIP3-Mediated Mitochondrial Autophagy in GK Rats

Deferoxamine Treatment Combined With Sevoflurane Postconditioning Attenuates Myocardial Ischemia-Reperfusion Injury by Restoring HIF-1/BNIP3-Mediated Mitochondrial Autophagy in GK Rats

Mitochondrial autophagy is involved in myocardial protection of sevoflurane postconditioning (SPostC) and in diabetic state this protective effect is weakened due to impaired HIF-1 signaling pathway. Previous studies have proved that deferoxamine (DFO) could activate impaired HIF-1α in diabetic stat...

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Bibliographic Details
Main Authors:	Long Yang, Peng Xie, Jianjiang Wu, Jin Yu, Xin Li, Haiping Ma, Tian Yu, Haiying Wang, Jianrong Ye, Jiang Wang, Hong Zheng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-02-01
Series:	Frontiers in Pharmacology
Subjects:	mitochondrial autophagy sevoflurane postconditioning diabetes ischemia-reperfusion hypoxia-inducible factor-1
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.00006/full

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