A new mutation of the Atoh1 gene in mice with normal life span allows analysis of inner ear and cerebellar phenotype in aging.

A new mutation of the Atoh1 gene in mice with normal life span allows analysis of inner ear and cerebellar phenotype in aging.

Atoh1 is a transcription factor that regulates neural development in multiple tissues and is conserved among species. Prior mouse models of Atoh1, though effective and important in the evolution of our understanding of the gene, have been limited by perinatal lethality. Here we describe a novel poin...

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Bibliographic Details
Main Authors: Kianoush Sheykholeslami, Vikrum Thimmappa, Casey Nava, Xiaohui Bai, Heping Yu, Tihua Zheng, Zhaoqiang Zhang, Sheng Li Li, Shuqing Liu, Qing Yin Zheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3827170?pdf=render

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