Tumor circulating biomarkers in colorectal cancer
CRC is a major global health concern and is responsible for a significant number of cancer-related deaths each year. The successful treatment of CRC becomes more difficult when it goes undetected until it has advanced to a later stage. Diagnostic biomarkers can play a critical role in the early dete...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
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| Series: | Cancer Treatment and Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294223001090 |
| _version_ | 1827355213630013440 |
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| author | Raana Bagheri Mohsen Ghorbian Saeid Ghorbian |
| author_facet | Raana Bagheri Mohsen Ghorbian Saeid Ghorbian |
| author_sort | Raana Bagheri |
| collection | DOAJ |
| description | CRC is a major global health concern and is responsible for a significant number of cancer-related deaths each year. The successful treatment of CRC becomes more difficult when it goes undetected until it has advanced to a later stage. Diagnostic biomarkers can play a critical role in the early detection of CRC, which leads to improved patient outcomes and increased survival rates. It is important to develop reliable biomarkers for the early detection of CRC to enable timely diagnosis and treatment. To date, CRC detection methods such as endoscopy, blood, and stool tests are imperfect and often only identify cases in the later stages of the disease. To overcome these limitations, researchers are turning to molecular biomarkers as a promising avenue for improving CRC detection. Diagnostic information can be provided more reliably through a noninvasive approach using biomarkers such as mRNA, circulating cell-free DNA, micro-RNA, long non-coding RNA, and proteins. These biomarkers can be found in blood, tissue, feces, and volatile organic compounds. The identification of molecular biomarkers with high sensitivity and specificity for early detection of CRC that are safe, cost-effective, and easily measurable remains a significant challenge for researchers. In this article, we will explore the latest advancements in blood-based diagnostic biomarkers for CRC and their potential impact on improving patient survival rates. |
| first_indexed | 2024-03-08T04:06:23Z |
| format | Article |
| id | doaj.art-36c6922dbb1d454fb286a5601a19bb6d |
| institution | Directory Open Access Journal |
| issn | 2468-2942 |
| language | English |
| last_indexed | 2024-03-08T04:06:23Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj.art-36c6922dbb1d454fb286a5601a19bb6d2024-02-09T04:48:52ZengElsevierCancer Treatment and Research Communications2468-29422024-01-0138100787Tumor circulating biomarkers in colorectal cancerRaana Bagheri0Mohsen Ghorbian1Saeid Ghorbian2Department of Molecular Genetics, Ahar Branch, Islamic Azad University, Ahar, IranDepartment of Computer Engineering, Qom Branch, Islamic Azad University, Qom, IranDepartment of Molecular Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran; Corresponding author.CRC is a major global health concern and is responsible for a significant number of cancer-related deaths each year. The successful treatment of CRC becomes more difficult when it goes undetected until it has advanced to a later stage. Diagnostic biomarkers can play a critical role in the early detection of CRC, which leads to improved patient outcomes and increased survival rates. It is important to develop reliable biomarkers for the early detection of CRC to enable timely diagnosis and treatment. To date, CRC detection methods such as endoscopy, blood, and stool tests are imperfect and often only identify cases in the later stages of the disease. To overcome these limitations, researchers are turning to molecular biomarkers as a promising avenue for improving CRC detection. Diagnostic information can be provided more reliably through a noninvasive approach using biomarkers such as mRNA, circulating cell-free DNA, micro-RNA, long non-coding RNA, and proteins. These biomarkers can be found in blood, tissue, feces, and volatile organic compounds. The identification of molecular biomarkers with high sensitivity and specificity for early detection of CRC that are safe, cost-effective, and easily measurable remains a significant challenge for researchers. In this article, we will explore the latest advancements in blood-based diagnostic biomarkers for CRC and their potential impact on improving patient survival rates.http://www.sciencedirect.com/science/article/pii/S2468294223001090Circulating biomarkersBlood biomarkerColorectal cancerCRC |
| spellingShingle | Raana Bagheri Mohsen Ghorbian Saeid Ghorbian Tumor circulating biomarkers in colorectal cancer Cancer Treatment and Research Communications Circulating biomarkers Blood biomarker Colorectal cancer CRC |
| title | Tumor circulating biomarkers in colorectal cancer |
| title_full | Tumor circulating biomarkers in colorectal cancer |
| title_fullStr | Tumor circulating biomarkers in colorectal cancer |
| title_full_unstemmed | Tumor circulating biomarkers in colorectal cancer |
| title_short | Tumor circulating biomarkers in colorectal cancer |
| title_sort | tumor circulating biomarkers in colorectal cancer |
| topic | Circulating biomarkers Blood biomarker Colorectal cancer CRC |
| url | http://www.sciencedirect.com/science/article/pii/S2468294223001090 |
| work_keys_str_mv | AT raanabagheri tumorcirculatingbiomarkersincolorectalcancer AT mohsenghorbian tumorcirculatingbiomarkersincolorectalcancer AT saeidghorbian tumorcirculatingbiomarkersincolorectalcancer |