Advances in the Mechanisms Affecting Meniscal Avascular Zone Repair and Therapies
Injuries to menisci are the most common disease among knee joint-related morbidities and cover a widespread population ranging from children and the general population to the old and athletes. Repair of the injuries in the meniscal avascular zone remains a significant challenge due to the limited in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.758217/full |
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| author | Wenqiang Yan Wenqiang Yan Wenqiang Yan Wenli Dai Wenli Dai Wenli Dai Jin Cheng Jin Cheng Jin Cheng Yifei Fan Yifei Fan Yifei Fan Tong Wu Tong Wu Tong Wu Fengyuan Zhao Fengyuan Zhao Fengyuan Zhao Jiahao Zhang Jiahao Zhang Jiahao Zhang Xiaoqing Hu Xiaoqing Hu Xiaoqing Hu Yingfang Ao Yingfang Ao Yingfang Ao |
| author_facet | Wenqiang Yan Wenqiang Yan Wenqiang Yan Wenli Dai Wenli Dai Wenli Dai Jin Cheng Jin Cheng Jin Cheng Yifei Fan Yifei Fan Yifei Fan Tong Wu Tong Wu Tong Wu Fengyuan Zhao Fengyuan Zhao Fengyuan Zhao Jiahao Zhang Jiahao Zhang Jiahao Zhang Xiaoqing Hu Xiaoqing Hu Xiaoqing Hu Yingfang Ao Yingfang Ao Yingfang Ao |
| author_sort | Wenqiang Yan |
| collection | DOAJ |
| description | Injuries to menisci are the most common disease among knee joint-related morbidities and cover a widespread population ranging from children and the general population to the old and athletes. Repair of the injuries in the meniscal avascular zone remains a significant challenge due to the limited intrinsic healing capacity compared to the peripheral vascularized zone. The current surgical strategies for avascular zone injuries remain insufficient to prevent the development of cartilage degeneration and the ultimate emergence of osteoarthritis (OA). Due to the drawbacks of current surgical methods, the research interest has been transferred toward facilitating meniscal avascular zone repair, where it is expected to maintain meniscal tissue integrity, prevent secondary cartilage degeneration and improve knee joint function, which is consistent with the current prevailing management idea to maintain the integrity of meniscal tissue whenever possible. Biological augmentations have emerged as an alternative to current surgical methods for meniscal avascular zone repair. However, understanding the specific biological mechanisms that affect meniscal avascular zone repair is critical for the development of novel and comprehensive biological augmentations. For this reason, this review firstly summarized the current surgical techniques, including meniscectomies and meniscal substitution. We then discuss the state-of-the-art biological mechanisms, including vascularization, inflammation, extracellular matrix degradation and cellular component that were associated with meniscal avascular zone healing and the advances in therapeutic strategies. Finally, perspectives for the future biological augmentations for meniscal avascular zone injuries will be given. |
| first_indexed | 2024-12-17T12:42:26Z |
| format | Article |
| id | doaj.art-36c87e671e854579aaeb5f33dc549050 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-17T12:42:26Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-36c87e671e854579aaeb5f33dc5490502022-12-21T21:47:54ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-10-01910.3389/fcell.2021.758217758217Advances in the Mechanisms Affecting Meniscal Avascular Zone Repair and TherapiesWenqiang Yan0Wenqiang Yan1Wenqiang Yan2Wenli Dai3Wenli Dai4Wenli Dai5Jin Cheng6Jin Cheng7Jin Cheng8Yifei Fan9Yifei Fan10Yifei Fan11Tong Wu12Tong Wu13Tong Wu14Fengyuan Zhao15Fengyuan Zhao16Fengyuan Zhao17Jiahao Zhang18Jiahao Zhang19Jiahao Zhang20Xiaoqing Hu21Xiaoqing Hu22Xiaoqing Hu23Yingfang Ao24Yingfang Ao25Yingfang Ao26Department of Sports Medicine, Peking University Third Hospital, Beijing, ChinaInstitute of Sports Medicine of Peking University, Beijing, ChinaBeijing Key Laboratory of Sports Injuries, Beijing, ChinaDepartment of Sports Medicine, Peking University Third Hospital, Beijing, ChinaInstitute of Sports Medicine of Peking University, Beijing, ChinaBeijing Key Laboratory of Sports Injuries, Beijing, ChinaDepartment of Sports Medicine, Peking University Third Hospital, Beijing, ChinaInstitute of Sports Medicine of Peking University, Beijing, ChinaBeijing Key Laboratory of Sports Injuries, Beijing, ChinaDepartment of Sports Medicine, Peking University Third Hospital, Beijing, ChinaInstitute of Sports Medicine of Peking University, Beijing, ChinaBeijing Key Laboratory of Sports Injuries, Beijing, ChinaDepartment of Sports Medicine, Peking University Third Hospital, Beijing, ChinaInstitute of Sports Medicine of Peking University, Beijing, ChinaBeijing Key Laboratory of Sports Injuries, Beijing, ChinaDepartment of Sports Medicine, Peking University Third Hospital, Beijing, ChinaInstitute of Sports Medicine of Peking University, Beijing, ChinaBeijing Key Laboratory of Sports Injuries, Beijing, ChinaDepartment of Sports Medicine, Peking University Third Hospital, Beijing, ChinaInstitute of Sports Medicine of Peking University, Beijing, ChinaBeijing Key Laboratory of Sports Injuries, Beijing, ChinaDepartment of Sports Medicine, Peking University Third Hospital, Beijing, ChinaInstitute of Sports Medicine of Peking University, Beijing, ChinaBeijing Key Laboratory of Sports Injuries, Beijing, ChinaDepartment of Sports Medicine, Peking University Third Hospital, Beijing, ChinaInstitute of Sports Medicine of Peking University, Beijing, ChinaBeijing Key Laboratory of Sports Injuries, Beijing, ChinaInjuries to menisci are the most common disease among knee joint-related morbidities and cover a widespread population ranging from children and the general population to the old and athletes. Repair of the injuries in the meniscal avascular zone remains a significant challenge due to the limited intrinsic healing capacity compared to the peripheral vascularized zone. The current surgical strategies for avascular zone injuries remain insufficient to prevent the development of cartilage degeneration and the ultimate emergence of osteoarthritis (OA). Due to the drawbacks of current surgical methods, the research interest has been transferred toward facilitating meniscal avascular zone repair, where it is expected to maintain meniscal tissue integrity, prevent secondary cartilage degeneration and improve knee joint function, which is consistent with the current prevailing management idea to maintain the integrity of meniscal tissue whenever possible. Biological augmentations have emerged as an alternative to current surgical methods for meniscal avascular zone repair. However, understanding the specific biological mechanisms that affect meniscal avascular zone repair is critical for the development of novel and comprehensive biological augmentations. For this reason, this review firstly summarized the current surgical techniques, including meniscectomies and meniscal substitution. We then discuss the state-of-the-art biological mechanisms, including vascularization, inflammation, extracellular matrix degradation and cellular component that were associated with meniscal avascular zone healing and the advances in therapeutic strategies. Finally, perspectives for the future biological augmentations for meniscal avascular zone injuries will be given.https://www.frontiersin.org/articles/10.3389/fcell.2021.758217/fullmeniscusmeniscal injuriesavascular zonebiological mechanismsbiological augmentation |
| spellingShingle | Wenqiang Yan Wenqiang Yan Wenqiang Yan Wenli Dai Wenli Dai Wenli Dai Jin Cheng Jin Cheng Jin Cheng Yifei Fan Yifei Fan Yifei Fan Tong Wu Tong Wu Tong Wu Fengyuan Zhao Fengyuan Zhao Fengyuan Zhao Jiahao Zhang Jiahao Zhang Jiahao Zhang Xiaoqing Hu Xiaoqing Hu Xiaoqing Hu Yingfang Ao Yingfang Ao Yingfang Ao Advances in the Mechanisms Affecting Meniscal Avascular Zone Repair and Therapies Frontiers in Cell and Developmental Biology meniscus meniscal injuries avascular zone biological mechanisms biological augmentation |
| title | Advances in the Mechanisms Affecting Meniscal Avascular Zone Repair and Therapies |
| title_full | Advances in the Mechanisms Affecting Meniscal Avascular Zone Repair and Therapies |
| title_fullStr | Advances in the Mechanisms Affecting Meniscal Avascular Zone Repair and Therapies |
| title_full_unstemmed | Advances in the Mechanisms Affecting Meniscal Avascular Zone Repair and Therapies |
| title_short | Advances in the Mechanisms Affecting Meniscal Avascular Zone Repair and Therapies |
| title_sort | advances in the mechanisms affecting meniscal avascular zone repair and therapies |
| topic | meniscus meniscal injuries avascular zone biological mechanisms biological augmentation |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.758217/full |
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