Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study
Introduction: Lower cerebral blood flow (CBF) is associated with cardiovascular disease and vascular risk factors, and is increasingly acknowledged as an important contributor to cognitive decline and dementia. In this cross-sectional study, we examined the association between CBF and cognitive func...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2018.00279/full |
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| author | Anna E. Leeuwis Lorna A. Smith Andrew Melbourne Alun D. Hughes Alun D. Hughes Marcus Richards Niels D. Prins Magdalena Sokolska David Atkinson Therese Tillin Hans R. Jäger Nish Chaturvedi Nish Chaturvedi Wiesje M. van der Flier Wiesje M. van der Flier Frederik Barkhof Frederik Barkhof |
| author_facet | Anna E. Leeuwis Lorna A. Smith Andrew Melbourne Alun D. Hughes Alun D. Hughes Marcus Richards Niels D. Prins Magdalena Sokolska David Atkinson Therese Tillin Hans R. Jäger Nish Chaturvedi Nish Chaturvedi Wiesje M. van der Flier Wiesje M. van der Flier Frederik Barkhof Frederik Barkhof |
| author_sort | Anna E. Leeuwis |
| collection | DOAJ |
| description | Introduction: Lower cerebral blood flow (CBF) is associated with cardiovascular disease and vascular risk factors, and is increasingly acknowledged as an important contributor to cognitive decline and dementia. In this cross-sectional study, we examined the association between CBF and cognitive functioning in a community-based, multi-ethnic cohort.Methods: From the SABRE (Southall and Brent Revisited) study, we included 214 European, 151 South Asian and 87 African Caribbean participants (71 ± 5 years; 39%F). We used 3T pseudo-continuous arterial spin labeling to estimate whole-brain, hematocrit corrected CBF. We measured global cognition and three cognitive domains (memory, executive functioning/attention and language) with a neuropsychological test battery. Associations were investigated using linear regression analyses, adjusted for demographic variables, vascular risk factors and MRI measures.Results: Across groups, we found an association between higher CBF and better performance on executive functioning/attention (standardized ß [stß] = 0.11, p < 0.05). Stratification for ethnicity showed associations between higher CBF and better performance on memory and executive functioning/attention in the white European group (stß = 0.14; p < 0.05 and stß = 0.18; p < 0.01 respectively), associations were weaker in the South Asian and African Caribbean groups.Conclusions: In a multi-ethnic community-based cohort we showed modest associations between CBF and cognitive functioning. In particular, we found an association between higher CBF and better performance on executive functioning/attention and memory in the white European group. The observations are consistent with the proposed role of cerebral hemodynamics in cognitive decline. |
| first_indexed | 2024-04-12T11:44:46Z |
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| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T11:44:46Z |
| publishDate | 2018-09-01 |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-36cebb2730974e2099e5446d7f2e28c62022-12-22T03:34:24ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-09-011010.3389/fnagi.2018.00279387050Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE StudyAnna E. Leeuwis0Lorna A. Smith1Andrew Melbourne2Alun D. Hughes3Alun D. Hughes4Marcus Richards5Niels D. Prins6Magdalena Sokolska7David Atkinson8Therese Tillin9Hans R. Jäger10Nish Chaturvedi11Nish Chaturvedi12Wiesje M. van der Flier13Wiesje M. van der Flier14Frederik Barkhof15Frederik Barkhof16Department of Neurology, Amsterdam Neuroscience, Alzheimer Center Amsterdam, Vrije Universiteit AmsterdamAmsterdam UMC, Amsterdam, NetherlandsDepartment of Population Science and Experimental Medicine, Institute of Cardiovascular ScienceUniversity College London, London, United KingdomTranslational Imaging Group, Department of Medical Physics and Biomedical EngineeringUniversity College London, London, United KingdomDepartment of Population Science and Experimental Medicine, Institute of Cardiovascular ScienceUniversity College London, London, United KingdomMRC Unit for Lifelong Health and AgeingUniversity College London, London, United KingdomMRC Unit for Lifelong Health and AgeingUniversity College London, London, United KingdomDepartment of Neurology, Amsterdam Neuroscience, Alzheimer Center Amsterdam, Vrije Universiteit AmsterdamAmsterdam UMC, Amsterdam, NetherlandsDepartment of Medical Physics and Biomedical EngineeringUniversity College London, London, United KingdomCentre for Medical ImagingUniversity College London, London, United KingdomDepartment of Population Science and Experimental Medicine, Institute of Cardiovascular ScienceUniversity College London, London, United KingdomNeuroradiological Academic Unit, Department of Brain Repair and RehabilitationUCL Institute of Neurology, London, United KingdomDepartment of Population Science and Experimental Medicine, Institute of Cardiovascular ScienceUniversity College London, London, United KingdomMRC Unit for Lifelong Health and AgeingUniversity College London, London, United KingdomDepartment of Neurology, Amsterdam Neuroscience, Alzheimer Center Amsterdam, Vrije Universiteit AmsterdamAmsterdam UMC, Amsterdam, NetherlandsDepartment of Epidemiology and Biostatistics, Vrije Universiteit AmsterdamAmsterdam UMC, Amsterdam, NetherlandsInstitutes of Neurology and Healthcare EngineeringUniversity College London, London, United Kingdom0Department of Radiology and Nuclear Medicine, Vrije Universiteit AmsterdamAmsterdam UMC, Amsterdam, NetherlandsIntroduction: Lower cerebral blood flow (CBF) is associated with cardiovascular disease and vascular risk factors, and is increasingly acknowledged as an important contributor to cognitive decline and dementia. In this cross-sectional study, we examined the association between CBF and cognitive functioning in a community-based, multi-ethnic cohort.Methods: From the SABRE (Southall and Brent Revisited) study, we included 214 European, 151 South Asian and 87 African Caribbean participants (71 ± 5 years; 39%F). We used 3T pseudo-continuous arterial spin labeling to estimate whole-brain, hematocrit corrected CBF. We measured global cognition and three cognitive domains (memory, executive functioning/attention and language) with a neuropsychological test battery. Associations were investigated using linear regression analyses, adjusted for demographic variables, vascular risk factors and MRI measures.Results: Across groups, we found an association between higher CBF and better performance on executive functioning/attention (standardized ß [stß] = 0.11, p < 0.05). Stratification for ethnicity showed associations between higher CBF and better performance on memory and executive functioning/attention in the white European group (stß = 0.14; p < 0.05 and stß = 0.18; p < 0.01 respectively), associations were weaker in the South Asian and African Caribbean groups.Conclusions: In a multi-ethnic community-based cohort we showed modest associations between CBF and cognitive functioning. In particular, we found an association between higher CBF and better performance on executive functioning/attention and memory in the white European group. The observations are consistent with the proposed role of cerebral hemodynamics in cognitive decline.https://www.frontiersin.org/article/10.3389/fnagi.2018.00279/fullcerebral perfusionarterial spin labelingcognitionneuropsychologyvascular risk factorsethnicity |
| spellingShingle | Anna E. Leeuwis Lorna A. Smith Andrew Melbourne Alun D. Hughes Alun D. Hughes Marcus Richards Niels D. Prins Magdalena Sokolska David Atkinson Therese Tillin Hans R. Jäger Nish Chaturvedi Nish Chaturvedi Wiesje M. van der Flier Wiesje M. van der Flier Frederik Barkhof Frederik Barkhof Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study Frontiers in Aging Neuroscience cerebral perfusion arterial spin labeling cognition neuropsychology vascular risk factors ethnicity |
| title | Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study |
| title_full | Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study |
| title_fullStr | Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study |
| title_full_unstemmed | Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study |
| title_short | Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study |
| title_sort | cerebral blood flow and cognitive functioning in a community based multi ethnic cohort the sabre study |
| topic | cerebral perfusion arterial spin labeling cognition neuropsychology vascular risk factors ethnicity |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2018.00279/full |
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