Regulatory role of exosomes in colorectal cancer progression and potential as biomarkers
Colorectal cancer (CRC) remains an enormous challenge to human health worldwide. Unfortunately, the mechanism underlying CRC progression is not well understood. Mounting evidence has confirmed that exosomes play a vital role in CRC progression, which has attracted extensive attention among researche...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2023-08-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | https://www.cancerbiomed.org/content/20/8/575 |
| _version_ | 1827825228368052224 |
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| author | Juan Hui Mingzhen Zhou Guangzhou An Hui Zhang Yuanyuan Lu Xin Wang Xiaodi Zhao |
| author_facet | Juan Hui Mingzhen Zhou Guangzhou An Hui Zhang Yuanyuan Lu Xin Wang Xiaodi Zhao |
| author_sort | Juan Hui |
| collection | DOAJ |
| description | Colorectal cancer (CRC) remains an enormous challenge to human health worldwide. Unfortunately, the mechanism underlying CRC progression is not well understood. Mounting evidence has confirmed that exosomes play a vital role in CRC progression, which has attracted extensive attention among researchers. In addition to acting as messengers between CRC cells, exosomes also participate in the CRC immunomodulatory process and reshape immune function. As stable message carriers and liquid biopsy option under development, exosomes are promising biomarkers in the diagnosis or treatment of CRC. In this review we have described and analyzed the biogenesis and release of exosomes and current research on the role of exosomes in immune regulation and metastasis of CRC. Moreover, we have discussed candidate exosomal molecules as potential biomarkers to diagnose CRC, predict CRC progression, or determine CRC chemoresistance, and described the significance of exosomes in the immunotherapy of CRC. This review provides insight to further understand the role of exosomes in CRC progression and identify valuable biomarkers that facilitate the clinical management of CRC patients. |
| first_indexed | 2024-03-12T02:39:07Z |
| format | Article |
| id | doaj.art-36d1cfe48caa4ee1aff92d5cd5501fbb |
| institution | Directory Open Access Journal |
| issn | 2095-3941 |
| language | English |
| last_indexed | 2024-03-12T02:39:07Z |
| publishDate | 2023-08-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-36d1cfe48caa4ee1aff92d5cd5501fbb2023-09-04T08:08:41ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412023-08-0120857559810.20892/j.issn.2095-3941.2023.0119Regulatory role of exosomes in colorectal cancer progression and potential as biomarkersJuan Hui0Mingzhen Zhou1Guangzhou An2Hui Zhang3Yuanyuan Lu4Xin Wang5Xiaodi Zhao6Department of Gastroenterology, Tangdu Hospital, Air Force Medical University, Xi’an 710038, ChinaState Key Laboratory of Cancer Biology and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi’an 710032, ChinaDepartment of Gastroenterology, Tangdu Hospital, Air Force Medical University, Xi’an 710038, ChinaDepartment of Gastroenterology, Tangdu Hospital, Air Force Medical University, Xi’an 710038, ChinaState Key Laboratory of Cancer Biology and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi’an 710032, ChinaDepartment of Gastroenterology, Tangdu Hospital, Air Force Medical University, Xi’an 710038, ChinaState Key Laboratory of Cancer Biology and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi’an 710032, ChinaColorectal cancer (CRC) remains an enormous challenge to human health worldwide. Unfortunately, the mechanism underlying CRC progression is not well understood. Mounting evidence has confirmed that exosomes play a vital role in CRC progression, which has attracted extensive attention among researchers. In addition to acting as messengers between CRC cells, exosomes also participate in the CRC immunomodulatory process and reshape immune function. As stable message carriers and liquid biopsy option under development, exosomes are promising biomarkers in the diagnosis or treatment of CRC. In this review we have described and analyzed the biogenesis and release of exosomes and current research on the role of exosomes in immune regulation and metastasis of CRC. Moreover, we have discussed candidate exosomal molecules as potential biomarkers to diagnose CRC, predict CRC progression, or determine CRC chemoresistance, and described the significance of exosomes in the immunotherapy of CRC. This review provides insight to further understand the role of exosomes in CRC progression and identify valuable biomarkers that facilitate the clinical management of CRC patients.https://www.cancerbiomed.org/content/20/8/575colorectal cancerexosomeimmunoregulationimmunotherapymetastasis |
| spellingShingle | Juan Hui Mingzhen Zhou Guangzhou An Hui Zhang Yuanyuan Lu Xin Wang Xiaodi Zhao Regulatory role of exosomes in colorectal cancer progression and potential as biomarkers Cancer Biology & Medicine colorectal cancer exosome immunoregulation immunotherapy metastasis |
| title | Regulatory role of exosomes in colorectal cancer progression and potential as biomarkers |
| title_full | Regulatory role of exosomes in colorectal cancer progression and potential as biomarkers |
| title_fullStr | Regulatory role of exosomes in colorectal cancer progression and potential as biomarkers |
| title_full_unstemmed | Regulatory role of exosomes in colorectal cancer progression and potential as biomarkers |
| title_short | Regulatory role of exosomes in colorectal cancer progression and potential as biomarkers |
| title_sort | regulatory role of exosomes in colorectal cancer progression and potential as biomarkers |
| topic | colorectal cancer exosome immunoregulation immunotherapy metastasis |
| url | https://www.cancerbiomed.org/content/20/8/575 |
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