Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis.
Visceral leishmaniasis (VL), one of the neglected tropical diseases, is endemic in the Indian subcontinent. Ficolins are circulating serum proteins of the lectin complement system and involved in innate immunity.We have estimated ficolin-2 serum levels and analyzed the functional variants of the enc...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4428791?pdf=render |
| _version_ | 1811231781388550144 |
|---|---|
| author | Anshuman Mishra Justin S Antony Pandarisamy Sundaravadivel Hoang Van Tong Christian G Meyer Reshma D Jalli Thirumalaisamy P Velavan Kumarasamy Thangaraj |
| author_facet | Anshuman Mishra Justin S Antony Pandarisamy Sundaravadivel Hoang Van Tong Christian G Meyer Reshma D Jalli Thirumalaisamy P Velavan Kumarasamy Thangaraj |
| author_sort | Anshuman Mishra |
| collection | DOAJ |
| description | Visceral leishmaniasis (VL), one of the neglected tropical diseases, is endemic in the Indian subcontinent. Ficolins are circulating serum proteins of the lectin complement system and involved in innate immunity.We have estimated ficolin-2 serum levels and analyzed the functional variants of the encoding gene FCN2 in 218 cases of VL and in 225 controls from an endemic region of India.Elevated levels of serum ficolin-2 were observed in VL cases compared to the controls (adjusted P<0.0001). The genetic analysis revealed that the FCN2 structural variant +6359 C>T (p.T236M) was associated with VL (OR=2.2, 95% CI=1.23-7.25, P=0.008) and with high ficolin-2 serum levels. We also found that the FCN2*AAAC haplotype occurred more frequently among healthy controls when compared to cases (OR=0.59, 95%CI=0.37-0.94, P=0.023).Our findings indicate that the FCN2 variant +6359C>T is associated with the occurrence of VL and that ficolin-2 serum levels are elevated in Leishmania infections. |
| first_indexed | 2024-04-12T10:51:53Z |
| format | Article |
| id | doaj.art-36d1fd0d929445089858e2eac1a43277 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T10:51:53Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-36d1fd0d929445089858e2eac1a432772022-12-22T03:36:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012594010.1371/journal.pone.0125940Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis.Anshuman MishraJustin S AntonyPandarisamy SundaravadivelHoang Van TongChristian G MeyerReshma D JalliThirumalaisamy P VelavanKumarasamy ThangarajVisceral leishmaniasis (VL), one of the neglected tropical diseases, is endemic in the Indian subcontinent. Ficolins are circulating serum proteins of the lectin complement system and involved in innate immunity.We have estimated ficolin-2 serum levels and analyzed the functional variants of the encoding gene FCN2 in 218 cases of VL and in 225 controls from an endemic region of India.Elevated levels of serum ficolin-2 were observed in VL cases compared to the controls (adjusted P<0.0001). The genetic analysis revealed that the FCN2 structural variant +6359 C>T (p.T236M) was associated with VL (OR=2.2, 95% CI=1.23-7.25, P=0.008) and with high ficolin-2 serum levels. We also found that the FCN2*AAAC haplotype occurred more frequently among healthy controls when compared to cases (OR=0.59, 95%CI=0.37-0.94, P=0.023).Our findings indicate that the FCN2 variant +6359C>T is associated with the occurrence of VL and that ficolin-2 serum levels are elevated in Leishmania infections.http://europepmc.org/articles/PMC4428791?pdf=render |
| spellingShingle | Anshuman Mishra Justin S Antony Pandarisamy Sundaravadivel Hoang Van Tong Christian G Meyer Reshma D Jalli Thirumalaisamy P Velavan Kumarasamy Thangaraj Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis. PLoS ONE |
| title | Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis. |
| title_full | Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis. |
| title_fullStr | Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis. |
| title_full_unstemmed | Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis. |
| title_short | Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis. |
| title_sort | association of ficolin 2 serum levels and fcn2 genetic variants with indian visceral leishmaniasis |
| url | http://europepmc.org/articles/PMC4428791?pdf=render |
| work_keys_str_mv | AT anshumanmishra associationofficolin2serumlevelsandfcn2geneticvariantswithindianvisceralleishmaniasis AT justinsantony associationofficolin2serumlevelsandfcn2geneticvariantswithindianvisceralleishmaniasis AT pandarisamysundaravadivel associationofficolin2serumlevelsandfcn2geneticvariantswithindianvisceralleishmaniasis AT hoangvantong associationofficolin2serumlevelsandfcn2geneticvariantswithindianvisceralleishmaniasis AT christiangmeyer associationofficolin2serumlevelsandfcn2geneticvariantswithindianvisceralleishmaniasis AT reshmadjalli associationofficolin2serumlevelsandfcn2geneticvariantswithindianvisceralleishmaniasis AT thirumalaisamypvelavan associationofficolin2serumlevelsandfcn2geneticvariantswithindianvisceralleishmaniasis AT kumarasamythangaraj associationofficolin2serumlevelsandfcn2geneticvariantswithindianvisceralleishmaniasis |