Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling

Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling

G Protein Suppressor 2 (GPS2) is a multifunctional protein that exerts important roles in inflammation and metabolism in adipose, liver, and immune cells. GPS2 has recently been identified as a significantly mutated gene in breast cancer and other malignancies and proposed to work as a putative tumo...

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Bibliographic Details
Main Authors: Stefanie Chan, Emma Smith, Yuan Gao, Julian Kwan, Benjamin C. Blum, Andrew M. Tilston-Lunel, Isabella Turcinovic, Xaralabos Varelas, Maria Dafne Cardamone, Stefano Monti, Andrew Emili, Valentina Perissi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
breast cancer
GPS2
ubiquitin (Ub)
MK2206 (PubChem CID: 46930998)
Akt
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.608044/full

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