A Reproducible Bioprinted 3D Tumor Model Serves as a Preselection Tool for CAR T Cell Therapy Optimization

A Reproducible Bioprinted 3D Tumor Model Serves as a Preselection Tool for CAR T Cell Therapy Optimization

Chimeric antigen receptor (CAR) T cell performance against solid tumors in mouse models and clinical trials is often less effective than predicted by CAR construct selection in two-dimensional (2D) cocultures. Three-dimensional (3D) solid tumor architecture is likely to be crucial for CAR T cell eff...

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Bibliographic Details
Main Authors: Laura Grunewald, Tobias Lam, Lena Andersch, Anika Klaus, Silke Schwiebert, Annika Winkler, Anton Gauert, Anja I. Heeren-Hagemann, Kathy Astrahantseff, Filippos Klironomos, Alexander Thomas, Hedwig E. Deubzer, Anton G. Henssen, Angelika Eggert, Johannes H. Schulte, Kathleen Anders, Lutz Kloke, Annette Künkele
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
CAR T cells
neuroblastoma
T cell infiltration
3D tumor model
bioprint technology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.689697/full

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