Extracellular matrix remodelling and stiffening contributes to tumorigenesis of salivary carcinoma ex pleomorphic adenoma——A study based on patient-derived organoids

Extracellular matrix remodelling and stiffening contributes to tumorigenesis of salivary carcinoma ex pleomorphic adenoma——A study based on patient-derived organoids

Abstract Background Salivary carcinoma ex pleomorphic adenoma (CXPA) is defined as a carcinoma that develops from benign pleomorphic adenoma (PA). Abnormally activated Androgen signaling pathway and amplification of HER-2/neu(ERBB-2) gene are known to be involved in CXPA tumorigenesis. Recent progre...

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Bibliographic Details
Main Authors: Wanling Chen, Ting Gu, Qianqian Chen, Chuxiang Qu, Chunye Zhang, Yuhua Hu, Ronghui Xia, Ying Zhang, Min Wang, Xinyi Huang, Jiang Li, Chaoji Shi, Zhen Tian
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Cell & Bioscience
Subjects:
Carcinoma ex pleomorphic adenoma
Extracellular matrix
Collagen
Remodelling
Stiffness
TWIST1
Online Access:https://doi.org/10.1186/s13578-023-01071-x

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