Event timing in associative learning: from biochemical reaction dynamics to behavioural observations.
Associative learning relies on event timing. Fruit flies for example, once trained with an odour that precedes electric shock, subsequently avoid this odour (punishment learning); if, on the other hand the odour follows the shock during training, it is approached later on (relief learning). During t...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3316544?pdf=render |
| _version_ | 1818287339330338816 |
|---|---|
| author | Ayse Yarali Johannes Nehrkorn Hiromu Tanimoto Andreas V M Herz |
| author_facet | Ayse Yarali Johannes Nehrkorn Hiromu Tanimoto Andreas V M Herz |
| author_sort | Ayse Yarali |
| collection | DOAJ |
| description | Associative learning relies on event timing. Fruit flies for example, once trained with an odour that precedes electric shock, subsequently avoid this odour (punishment learning); if, on the other hand the odour follows the shock during training, it is approached later on (relief learning). During training, an odour-induced Ca(++) signal and a shock-induced dopaminergic signal converge in the Kenyon cells, synergistically activating a Ca(++)-calmodulin-sensitive adenylate cyclase, which likely leads to the synaptic plasticity underlying the conditioned avoidance of the odour. In Aplysia, the effect of serotonin on the corresponding adenylate cyclase is bi-directionally modulated by Ca(++), depending on the relative timing of the two inputs. Using a computational approach, we quantitatively explore this biochemical property of the adenylate cyclase and show that it can generate the effect of event timing on associative learning. We overcome the shortage of behavioural data in Aplysia and biochemical data in Drosophila by combining findings from both systems. |
| first_indexed | 2024-12-13T01:38:55Z |
| format | Article |
| id | doaj.art-36d5ded7eaaf44a3be7ef2f7d88bfd83 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T01:38:55Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-36d5ded7eaaf44a3be7ef2f7d88bfd832022-12-22T00:03:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0173e3288510.1371/journal.pone.0032885Event timing in associative learning: from biochemical reaction dynamics to behavioural observations.Ayse YaraliJohannes NehrkornHiromu TanimotoAndreas V M HerzAssociative learning relies on event timing. Fruit flies for example, once trained with an odour that precedes electric shock, subsequently avoid this odour (punishment learning); if, on the other hand the odour follows the shock during training, it is approached later on (relief learning). During training, an odour-induced Ca(++) signal and a shock-induced dopaminergic signal converge in the Kenyon cells, synergistically activating a Ca(++)-calmodulin-sensitive adenylate cyclase, which likely leads to the synaptic plasticity underlying the conditioned avoidance of the odour. In Aplysia, the effect of serotonin on the corresponding adenylate cyclase is bi-directionally modulated by Ca(++), depending on the relative timing of the two inputs. Using a computational approach, we quantitatively explore this biochemical property of the adenylate cyclase and show that it can generate the effect of event timing on associative learning. We overcome the shortage of behavioural data in Aplysia and biochemical data in Drosophila by combining findings from both systems.http://europepmc.org/articles/PMC3316544?pdf=render |
| spellingShingle | Ayse Yarali Johannes Nehrkorn Hiromu Tanimoto Andreas V M Herz Event timing in associative learning: from biochemical reaction dynamics to behavioural observations. PLoS ONE |
| title | Event timing in associative learning: from biochemical reaction dynamics to behavioural observations. |
| title_full | Event timing in associative learning: from biochemical reaction dynamics to behavioural observations. |
| title_fullStr | Event timing in associative learning: from biochemical reaction dynamics to behavioural observations. |
| title_full_unstemmed | Event timing in associative learning: from biochemical reaction dynamics to behavioural observations. |
| title_short | Event timing in associative learning: from biochemical reaction dynamics to behavioural observations. |
| title_sort | event timing in associative learning from biochemical reaction dynamics to behavioural observations |
| url | http://europepmc.org/articles/PMC3316544?pdf=render |
| work_keys_str_mv | AT ayseyarali eventtiminginassociativelearningfrombiochemicalreactiondynamicstobehaviouralobservations AT johannesnehrkorn eventtiminginassociativelearningfrombiochemicalreactiondynamicstobehaviouralobservations AT hiromutanimoto eventtiminginassociativelearningfrombiochemicalreactiondynamicstobehaviouralobservations AT andreasvmherz eventtiminginassociativelearningfrombiochemicalreactiondynamicstobehaviouralobservations |