Clinical characteristics of children with airway malacia complicated by pneumonia
Abstract Background Airway malacia is an important cause of noisy breathing, recurrent wheezing and respiratory infections, chronic coughing, and episodes of respiratory distress in young children. As the clinical manifestations of airway malacia are not common, many clinicians have insufficient und...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-021-06603-9 |
| _version_ | 1819029342857986048 |
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| author | Ting Wang Qiuyan Xu Ge Dai Yu Hong Zhengrong Chen Min Lu Yongdong Yan Wujun Jiang |
| author_facet | Ting Wang Qiuyan Xu Ge Dai Yu Hong Zhengrong Chen Min Lu Yongdong Yan Wujun Jiang |
| author_sort | Ting Wang |
| collection | DOAJ |
| description | Abstract Background Airway malacia is an important cause of noisy breathing, recurrent wheezing and respiratory infections, chronic coughing, and episodes of respiratory distress in young children. As the clinical manifestations of airway malacia are not common, many clinicians have insufficient understanding of this disease. So the purpose of this study is to summarize the pathogenic bacteria and clinical manifestations of airway softening complicated with pneumonia in children. Methods Children hospitalized with airway malacia complicated by pneumonia were eligible for enrollment from January 1, 2013 to December 31, 2019. Medical records of patients were reviewed for etiology, clinical characteristics, and laboratory examination results. Results A total of 164 pneumonia patients with airway malacia were admitted. The male-to-female ratio was 3:1. The age of patients ranged from 1 month to 4 years old. The median age was 6 (3–10) months. The most commonly detected pathogen were Mycoplasma pneumoniae (25/164, 15.24%), Streptococcus pneumoniae (18/164, 10.98%), and respiratory syncytial virus (16/164, 9.76%). Common signs among the 164 patients with confirmed airway malacia included cough (98.78%), wheezing (67.07%), fever (35.37%), intercostal retractions (23.17%), dyspnea (10.98%), cyanosis (11.11%), and crackles (50%). Compared with those without airway malacia, the incidence of premature delivery and mechanical ventilation was higher, and the duration of symptoms before admission (median, 13.5 d) and hospital stay (median 10.0 d) were longer. Of the children with pneumonia, 11.59% of those with airway malacia required supplemental oxygen compared with 4.88% of those without airway malacia (p < 0.05). Conclusion The median age of children with airway malacia was 6 months. The most common pathogen in patients with airway malacia complicated by pneumonia was Mycoplasma pneumoniae. Patients with airway malacia complicated by pneumonia often presented with a longer disease course, more severe symptoms, and had delayed recovery. |
| first_indexed | 2024-12-21T06:12:45Z |
| format | Article |
| id | doaj.art-36d66cdd672d4fbea9bc1becd0ce5f34 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-21T06:12:45Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-36d66cdd672d4fbea9bc1becd0ce5f342022-12-21T19:13:30ZengBMCBMC Infectious Diseases1471-23342021-09-012111810.1186/s12879-021-06603-9Clinical characteristics of children with airway malacia complicated by pneumoniaTing Wang0Qiuyan Xu1Ge Dai2Yu Hong3Zhengrong Chen4Min Lu5Yongdong Yan6Wujun Jiang7Department of Respiratory Medicine, Children’s Hospital of Soochow UniversityDepartment of Pediatrics, The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical UniversityDepartment of Respiratory Medicine, Children’s Hospital of Soochow UniversityDepartment of Respiratory Medicine, Children’s Hospital of Soochow UniversityDepartment of Respiratory Medicine, Children’s Hospital of Soochow UniversityDepartment of Pediatrics, The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical UniversityDepartment of Respiratory Medicine, Children’s Hospital of Soochow UniversityDepartment of Respiratory Medicine, Children’s Hospital of Soochow UniversityAbstract Background Airway malacia is an important cause of noisy breathing, recurrent wheezing and respiratory infections, chronic coughing, and episodes of respiratory distress in young children. As the clinical manifestations of airway malacia are not common, many clinicians have insufficient understanding of this disease. So the purpose of this study is to summarize the pathogenic bacteria and clinical manifestations of airway softening complicated with pneumonia in children. Methods Children hospitalized with airway malacia complicated by pneumonia were eligible for enrollment from January 1, 2013 to December 31, 2019. Medical records of patients were reviewed for etiology, clinical characteristics, and laboratory examination results. Results A total of 164 pneumonia patients with airway malacia were admitted. The male-to-female ratio was 3:1. The age of patients ranged from 1 month to 4 years old. The median age was 6 (3–10) months. The most commonly detected pathogen were Mycoplasma pneumoniae (25/164, 15.24%), Streptococcus pneumoniae (18/164, 10.98%), and respiratory syncytial virus (16/164, 9.76%). Common signs among the 164 patients with confirmed airway malacia included cough (98.78%), wheezing (67.07%), fever (35.37%), intercostal retractions (23.17%), dyspnea (10.98%), cyanosis (11.11%), and crackles (50%). Compared with those without airway malacia, the incidence of premature delivery and mechanical ventilation was higher, and the duration of symptoms before admission (median, 13.5 d) and hospital stay (median 10.0 d) were longer. Of the children with pneumonia, 11.59% of those with airway malacia required supplemental oxygen compared with 4.88% of those without airway malacia (p < 0.05). Conclusion The median age of children with airway malacia was 6 months. The most common pathogen in patients with airway malacia complicated by pneumonia was Mycoplasma pneumoniae. Patients with airway malacia complicated by pneumonia often presented with a longer disease course, more severe symptoms, and had delayed recovery.https://doi.org/10.1186/s12879-021-06603-9Airway malaciaPneumoniaChidrenClinical characteristics |
| spellingShingle | Ting Wang Qiuyan Xu Ge Dai Yu Hong Zhengrong Chen Min Lu Yongdong Yan Wujun Jiang Clinical characteristics of children with airway malacia complicated by pneumonia BMC Infectious Diseases Airway malacia Pneumonia Chidren Clinical characteristics |
| title | Clinical characteristics of children with airway malacia complicated by pneumonia |
| title_full | Clinical characteristics of children with airway malacia complicated by pneumonia |
| title_fullStr | Clinical characteristics of children with airway malacia complicated by pneumonia |
| title_full_unstemmed | Clinical characteristics of children with airway malacia complicated by pneumonia |
| title_short | Clinical characteristics of children with airway malacia complicated by pneumonia |
| title_sort | clinical characteristics of children with airway malacia complicated by pneumonia |
| topic | Airway malacia Pneumonia Chidren Clinical characteristics |
| url | https://doi.org/10.1186/s12879-021-06603-9 |
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