Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs
Zwitterions consist of equal molar cationic and anionic moieties and thus exhibit overall electroneutrality. Zwitterionic materials include phosphorylcholine, sulfobetaine, carboxybetaine, zwitterionic amino acids/peptides, and other mix-charged zwitterions that could form dense and stable hydration...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Computational and Structural Biotechnology Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037020303470 |
| _version_ | 1818573714931843072 |
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| author | Ling-Yan Zhou Yang-Hui Zhu Xiao-Yu Wang Chao Shen Xia-Wei Wei Ting Xu Zhi-Yao He |
| author_facet | Ling-Yan Zhou Yang-Hui Zhu Xiao-Yu Wang Chao Shen Xia-Wei Wei Ting Xu Zhi-Yao He |
| author_sort | Ling-Yan Zhou |
| collection | DOAJ |
| description | Zwitterions consist of equal molar cationic and anionic moieties and thus exhibit overall electroneutrality. Zwitterionic materials include phosphorylcholine, sulfobetaine, carboxybetaine, zwitterionic amino acids/peptides, and other mix-charged zwitterions that could form dense and stable hydration shells through the strong ion–dipole interaction among water molecules and zwitterions. As a result of their remarkable hydration capability and low interfacial energy, zwitterionic materials have become ideal choices for designing therapeutic vectors to prevent undesired biosorption especially nonspecific biomacromolecules during circulation, which was termed antifouling capability. And along with their great biocompatibility, low cytotoxicity, negligible immunogenicity, systematic stability and long circulation time, zwitterionic materials have been widely utilized for the delivery of drugs and therapeutic genes. In this review, we first summarized the possible antifouling mechanism of zwitterions briefly, and separately introduced the features and advantages of each type of zwitterionic materials. Then we highlighted their applications in stimuli-responsive “intelligent” drug delivery systems as well as tumor-targeting carriers and stressed the multifunctional role they played in therapeutic gene delivery. |
| first_indexed | 2024-12-15T00:16:08Z |
| format | Article |
| id | doaj.art-36d74b1ee69f41029ab92be0ad104d9b |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-12-15T00:16:08Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-36d74b1ee69f41029ab92be0ad104d9b2022-12-21T22:42:28ZengElsevierComputational and Structural Biotechnology Journal2001-03702020-01-011819801999Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugsLing-Yan Zhou0Yang-Hui Zhu1Xiao-Yu Wang2Chao Shen3Xia-Wei Wei4Ting Xu5Zhi-Yao He6Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, ChinaDepartment of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, ChinaDepartment of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, ChinaDepartment of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, ChinaLaboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, ChinaDepartment of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China; Corresponding authors at: Department of Pharmacy, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China.Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China; Corresponding authors at: Department of Pharmacy, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China.Zwitterions consist of equal molar cationic and anionic moieties and thus exhibit overall electroneutrality. Zwitterionic materials include phosphorylcholine, sulfobetaine, carboxybetaine, zwitterionic amino acids/peptides, and other mix-charged zwitterions that could form dense and stable hydration shells through the strong ion–dipole interaction among water molecules and zwitterions. As a result of their remarkable hydration capability and low interfacial energy, zwitterionic materials have become ideal choices for designing therapeutic vectors to prevent undesired biosorption especially nonspecific biomacromolecules during circulation, which was termed antifouling capability. And along with their great biocompatibility, low cytotoxicity, negligible immunogenicity, systematic stability and long circulation time, zwitterionic materials have been widely utilized for the delivery of drugs and therapeutic genes. In this review, we first summarized the possible antifouling mechanism of zwitterions briefly, and separately introduced the features and advantages of each type of zwitterionic materials. Then we highlighted their applications in stimuli-responsive “intelligent” drug delivery systems as well as tumor-targeting carriers and stressed the multifunctional role they played in therapeutic gene delivery.http://www.sciencedirect.com/science/article/pii/S2001037020303470ZwitterionBiomaterialsAntifoulingGene deliveryDrug delivery |
| spellingShingle | Ling-Yan Zhou Yang-Hui Zhu Xiao-Yu Wang Chao Shen Xia-Wei Wei Ting Xu Zhi-Yao He Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs Computational and Structural Biotechnology Journal Zwitterion Biomaterials Antifouling Gene delivery Drug delivery |
| title | Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs |
| title_full | Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs |
| title_fullStr | Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs |
| title_full_unstemmed | Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs |
| title_short | Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs |
| title_sort | novel zwitterionic vectors multi functional delivery systems for therapeutic genes and drugs |
| topic | Zwitterion Biomaterials Antifouling Gene delivery Drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2001037020303470 |
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